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CLC number: R739.6

On-line Access: 2018-03-05

Received: 2017-02-23

Revision Accepted: 2017-07-12

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 ORCID:

Xu-xu Liu

https://orcid.org/0000-0002-2387-0653

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Journal of Zhejiang University SCIENCE B 2018 Vol.19 No.3 P.171-182

10.1631/jzus.B1700102


Roles of flotillins in tumors


Author(s):  Xu-xu Liu, Wei-dong Liu, Lei Wang, Bin Zhu, Xiao Shi, Zi-xuan Peng, He-cheng Zhu, Xing-dong Liu, Mei-zuo Zhong, Dan Xie, Mu-sheng Zeng, Cai-ping Ren

Affiliation(s):  Cancer Research Institute, Collaborative Innovation Center for Cancer Medicine, Key Laboratory for Carcinogenesis of Chinese Ministry of Health, Central South University, Changsha 410078, China; more

Corresponding email(s):   rencaiping@csu.edu.cn

Key Words:  Flotillins, Tumor, Lipid raft protein, Signal transduction


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Xu-xu Liu, Wei-dong Liu, Lei Wang, Bin Zhu, Xiao Shi, Zi-xuan Peng, He-cheng Zhu, Xing-dong Liu, Mei-zuo Zhong, Dan Xie, Mu-sheng Zeng, Cai-ping Ren. Roles of flotillins in tumors[J]. Journal of Zhejiang University Science B, 2018, 19(1): 171-182.

@article{title="Roles of flotillins in tumors",
author="Xu-xu Liu, Wei-dong Liu, Lei Wang, Bin Zhu, Xiao Shi, Zi-xuan Peng, He-cheng Zhu, Xing-dong Liu, Mei-zuo Zhong, Dan Xie, Mu-sheng Zeng, Cai-ping Ren",
journal="Journal of Zhejiang University Science B",
volume="19",
number="3",
pages="171-182",
year="2018",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1700102"
}

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%A Xu-xu Liu
%A Wei-dong Liu
%A Lei Wang
%A Bin Zhu
%A Xiao Shi
%A Zi-xuan Peng
%A He-cheng Zhu
%A Xing-dong Liu
%A Mei-zuo Zhong
%A Dan Xie
%A Mu-sheng Zeng
%A Cai-ping Ren
%J Journal of Zhejiang University SCIENCE B
%V 19
%N 3
%P 171-182
%@ 1673-1581
%D 2018
%I Zhejiang University Press & Springer

TY - JOUR
T1 - Roles of flotillins in tumors
A1 - Xu-xu Liu
A1 - Wei-dong Liu
A1 - Lei Wang
A1 - Bin Zhu
A1 - Xiao Shi
A1 - Zi-xuan Peng
A1 - He-cheng Zhu
A1 - Xing-dong Liu
A1 - Mei-zuo Zhong
A1 - Dan Xie
A1 - Mu-sheng Zeng
A1 - Cai-ping Ren
J0 - Journal of Zhejiang University Science B
VL - 19
IS - 3
SP - 171
EP - 182
%@ 1673-1581
Y1 - 2018
PB - Zhejiang University Press & Springer
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Abstract: 
The identification and use of molecular biomarkers have greatly improved the diagnosis and treatment of malignant tumors. However, a much deeper understanding of oncogenic proteins is needed for the benefit to cancer patients. The lipid raft marker proteins, flotillin-1 and flotillin-2, were first found in goldfish retinal ganglion cells during axon regeneration. They have since been found in a variety of cells, mainly on the inner surface of cell membranes, and not only act as a skeleton to provide a platform for protein–protein interactions, but also are involved in signal transduction, nerve regeneration, endocytosis, and lymphocyte activation. Previous studies have shown that flotillins are closely associated with tumor development, invasion, and metastasis. In this article, we review the functions of flotillins in relevant cell processes, their underlying mechanisms of action in a variety of tumors, and their potential applications to tumor molecular diagnosis and targeted therapy.

脂筏标记蛋白flotillins在肿瘤中的研究进展

概要:本文旨在对flotillins在相关细胞进程中的作用、在多种肿瘤中的作用和机制及其在肿瘤分子诊断和靶向治疗等方面的潜在应用价值进行综述.图1以示意图的形式直观地展示flotillin-1和flotillin-2的蛋白结构;表1对flotillin-1和flotillin-2在各种肿瘤中的表达异常情况、发挥的生物学功能及其机制进行汇总;在图2中,以模式图的形式展示flotillin-1和flotillin-2在肿瘤细胞中参与的信号通路及导致肿瘤细胞出现的不同表型.许多研究表明,flotillins在多种肿瘤中过表达,并且与肿瘤的发生发展、分期和转移密切相关.转移标志着肿瘤由局部病变发展为不可治愈的系统病变,是肿瘤预后的一个重要影响因素,但是其机制尚未完全阐述.因此,对其机制进行进一步探索有助于促进恶性肿瘤分子诊断、预后和精准治疗的发展.
关键词:Flotillins;肿瘤;脂筏标记蛋白;信号传导

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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