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Received: 2017-02-23

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Xu-xu Liu


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Journal of Zhejiang University SCIENCE B 2018 Vol.19 No.3 P.171-182


Roles of flotillins in tumors

Author(s):  Xu-xu Liu, Wei-dong Liu, Lei Wang, Bin Zhu, Xiao Shi, Zi-xuan Peng, He-cheng Zhu, Xing-dong Liu, Mei-zuo Zhong, Dan Xie, Mu-sheng Zeng, Cai-ping Ren

Affiliation(s):  Cancer Research Institute, Collaborative Innovation Center for Cancer Medicine, Key Laboratory for Carcinogenesis of Chinese Ministry of Health, Central South University, Changsha 410078, China; more

Corresponding email(s):   rencaiping@csu.edu.cn

Key Words:  Flotillins, Tumor, Lipid raft protein, Signal transduction

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Xu-xu Liu, Wei-dong Liu, Lei Wang, Bin Zhu, Xiao Shi, Zi-xuan Peng, He-cheng Zhu, Xing-dong Liu, Mei-zuo Zhong, Dan Xie, Mu-sheng Zeng, Cai-ping Ren. Roles of flotillins in tumors[J]. Journal of Zhejiang University Science B, 2018, 19(1): 171-182.

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journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

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%A Xing-dong Liu
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A1 - He-cheng Zhu
A1 - Xing-dong Liu
A1 - Mei-zuo Zhong
A1 - Dan Xie
A1 - Mu-sheng Zeng
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PB - Zhejiang University Press & Springer
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The identification and use of molecular biomarkers have greatly improved the diagnosis and treatment of malignant tumors. However, a much deeper understanding of oncogenic proteins is needed for the benefit to cancer patients. The lipid raft marker proteins, flotillin-1 and flotillin-2, were first found in goldfish retinal ganglion cells during axon regeneration. They have since been found in a variety of cells, mainly on the inner surface of cell membranes, and not only act as a skeleton to provide a platform for protein–protein interactions, but also are involved in signal transduction, nerve regeneration, endocytosis, and lymphocyte activation. Previous studies have shown that flotillins are closely associated with tumor development, invasion, and metastasis. In this article, we review the functions of flotillins in relevant cell processes, their underlying mechanisms of action in a variety of tumors, and their potential applications to tumor molecular diagnosis and targeted therapy.



Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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