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On-line Access: 2018-09-04

Received: 2017-07-07

Revision Accepted: 2018-01-25

Crosschecked: 2018-08-07

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Sheng-tao Zhao


Chang-zheng Wang


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Journal of Zhejiang University SCIENCE B 2018 Vol.19 No.9 P.663-673


Regulatory T cells and asthma

Author(s):  Sheng-tao Zhao, Chang-zheng Wang

Affiliation(s):  Institute of Respiratory Disease, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China; more

Corresponding email(s):   czwang@netease.com

Key Words:  Regulatory T cell, Asthma, Transforming growth factor β, (TGF-β, ), Interleukin 10 (IL-10), IL-35

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Sheng-tao Zhao, Chang-zheng Wang. Regulatory T cells and asthma[J]. Journal of Zhejiang University Science B, 2018, 19(1): 663-673.

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A1 - Sheng-tao Zhao
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asthma is a chronic disease of airway inflammation due to excessive T helper cell type 2 (Th2) response. Present treatment based on inhalation of synthetic glucocorticoids can only control Th2-driven chronic eosinophilic inflammation, but cannot change the immune tolerance of the body to external allergens. regulatory T cells (Tregs) are the main negative regulatory cells of the immune response. Tregs play a great role in regulating allergic, autoimmune, graft-versus-host responses, and other immune responses. In this review, we will discuss the classification and biological characteristics, the established immunomodulatory mechanisms, and the characteristics of induced differentiation of Tregs. We will also discuss the progress of Tregs in the field of asthma. We believe that further studies on the regulatory mechanisms of Tregs will provide better treatments and control strategies for asthma.



Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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