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CLC number: R562.25

On-line Access: 2018-09-04

Received: 2017-07-07

Revision Accepted: 2018-01-25

Crosschecked: 2018-08-07

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Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Sheng-tao Zhao

https://orcid.org/0000-0002-7994-0059

Chang-zheng Wang

https://orcid.org/0000-0002-8991-1315

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Journal of Zhejiang University SCIENCE B 2018 Vol.19 No.9 P.663-673

10.1631/jzus.B1700346


Regulatory T cells and asthma


Author(s):  Sheng-tao Zhao, Chang-zheng Wang

Affiliation(s):  Institute of Respiratory Disease, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China; more

Corresponding email(s):   czwang@netease.com

Key Words:  Regulatory T cell, Asthma, Transforming growth factor β, (TGF-β, ), Interleukin 10 (IL-10), IL-35


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Sheng-tao Zhao, Chang-zheng Wang. Regulatory T cells and asthma[J]. Journal of Zhejiang University Science B, 2018, 19(1): 663-673.

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publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1700346"
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Abstract: 
asthma is a chronic disease of airway inflammation due to excessive T helper cell type 2 (Th2) response. Present treatment based on inhalation of synthetic glucocorticoids can only control Th2-driven chronic eosinophilic inflammation, but cannot change the immune tolerance of the body to external allergens. regulatory T cells (Tregs) are the main negative regulatory cells of the immune response. Tregs play a great role in regulating allergic, autoimmune, graft-versus-host responses, and other immune responses. In this review, we will discuss the classification and biological characteristics, the established immunomodulatory mechanisms, and the characteristics of induced differentiation of Tregs. We will also discuss the progress of Tregs in the field of asthma. We believe that further studies on the regulatory mechanisms of Tregs will provide better treatments and control strategies for asthma.

调节性T细胞与哮喘

概要:哮喘是一种由于II型T辅助细胞(Th2)反应过度而引起的慢性气道炎症疾病.目前以吸入糖皮质激素为基础的治疗仅能控制Th2驱动的慢性嗜酸性炎症,但是不能改变机体对外界过敏原的免疫耐受状态.调节性T细胞(Tregs)是免疫应答的主要负调节细胞,Tregs在调节变态反应、自身免疫反应、移植物抗宿主反应和其他免疫反应中发挥着重要作用.在本文中,我们综述了Tregs的分类和生物学特性、免疫调节机制及诱导分化特性.我们也探讨了Tregs在哮喘领域的研究进展.我们相信,进一步对Tregs调控免疫反应机制的研究会为哮喘防控提供更好的治疗方案和策略.
关键词:调节性T细胞;哮喘;转变生长因子β(TGF-β);白介素10(IL-10);IL-35

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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