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On-line Access: 2019-01-22

Received: 2018-02-07

Revision Accepted: 2018-05-23

Crosschecked: 2018-06-06

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Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Shan Sun

https://orcid.org/0000-0003-2142-4307

Hua-Wei Li

https://orcid.org/0000-0002-3394-2278

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Journal of Zhejiang University SCIENCE B 2019 Vol.20 No.2 P.131-145

http://doi.org/10.1631/jzus.B1800084


Bone morphogenetic proteins and inner ear development


Author(s):  Jiao-Yao Ma, Dan You, Wen-Yan Li, Xiao-Ling Lu, Shan Sun, Hua-Wei Li

Affiliation(s):  Ear, Nose & Throat Institute and Otorhinolaryngology Department of Affiliated Eye and ENT Hospital, NHC Key Laboratory of Hearing Medicine, Shanghai Engineering Research Centre of Cochlear Implant, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200031, China; more

Corresponding email(s):   shansun@fudan.edu.cn, lihuawei63@gmail.com

Key Words:  Bone morphogenetic protein (BMP) signaling, Development, Inner ear, Hearing, Balance


Jiao-Yao Ma, Dan You, Wen-Yan Li, Xiao-Ling Lu, Shan Sun, Hua-Wei Li. Bone morphogenetic proteins and inner ear development[J]. Journal of Zhejiang University Science B, 2019, 20(2): 131-145.

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author="Jiao-Yao Ma, Dan You, Wen-Yan Li, Xiao-Ling Lu, Shan Sun, Hua-Wei Li",
journal="Journal of Zhejiang University Science B",
volume="20",
number="2",
pages="131-145",
year="2019",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1800084"
}

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%T Bone morphogenetic proteins and inner ear development
%A Jiao-Yao Ma
%A Dan You
%A Wen-Yan Li
%A Xiao-Ling Lu
%A Shan Sun
%A Hua-Wei Li
%J Journal of Zhejiang University SCIENCE B
%V 20
%N 2
%P 131-145
%@ 1673-1581
%D 2019
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1800084

TY - JOUR
T1 - Bone morphogenetic proteins and inner ear development
A1 - Jiao-Yao Ma
A1 - Dan You
A1 - Wen-Yan Li
A1 - Xiao-Ling Lu
A1 - Shan Sun
A1 - Hua-Wei Li
J0 - Journal of Zhejiang University Science B
VL - 20
IS - 2
SP - 131
EP - 145
%@ 1673-1581
Y1 - 2019
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1800084


Abstract: 
Bone morphogenetic proteins (BMPs) are the largest subfamily of the transforming growth factor-β superfamily, and they play important roles in the development of numerous organs, including the inner ear. The inner ear is a relatively small organ but has a highly complex structure and is involved in both hearing and balance. Here, we discuss BMPs and BMP signaling pathways and then focus on the role of BMP signal pathway regulation in the development of the inner ear and the implications this has for the treatment of human hearing loss and balance dysfunction.

骨形态发生蛋白与内耳发育的研究进展

概要:骨形态发生蛋白(BMP)是转化生长因子-β超家族中最大的亚家族,它们在许多器官(包括内耳)的发育中发挥重要作用.内耳是一个较小的器官,但其具有非常复杂的结构并且与听觉和平衡相关.本文先着重于BMPs及其BMP信号通路的介绍,后以内耳的发育时间为轴线,配合图片,介绍了BMP信号通路在内耳发育的不同阶段的影响以及对于内耳的不同部位的发育的影响,并概括了最新的内耳发育领域关于BMP信号通路的研究,为之后的内耳发育以及毛细胞再生的研究提供参考.
关键词:骨形态发生蛋白(BMP)信号通路;发育;内耳;听觉;平衡

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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