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Received: 2018-02-07

Revision Accepted: 2018-05-23

Crosschecked: 2018-06-06

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Shan Sun


Hua-Wei Li


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Journal of Zhejiang University SCIENCE B 2019 Vol.20 No.2 P.131-145


Bone morphogenetic proteins and inner ear development

Author(s):  Jiao-Yao Ma, Dan You, Wen-Yan Li, Xiao-Ling Lu, Shan Sun, Hua-Wei Li

Affiliation(s):  Ear, Nose & Throat Institute and Otorhinolaryngology Department of Affiliated Eye and ENT Hospital, NHC Key Laboratory of Hearing Medicine, Shanghai Engineering Research Centre of Cochlear Implant, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200031, China; more

Corresponding email(s):   shansun@fudan.edu.cn, lihuawei63@gmail.com

Key Words:  Bone morphogenetic protein (BMP) signaling, Development, Inner ear, Hearing, Balance

Jiao-Yao Ma, Dan You, Wen-Yan Li, Xiao-Ling Lu, Shan Sun, Hua-Wei Li. Bone morphogenetic proteins and inner ear development[J]. Journal of Zhejiang University Science B, 2019, 20(2): 131-145.

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PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B1800084

Bone morphogenetic proteins (BMPs) are the largest subfamily of the transforming growth factor-β superfamily, and they play important roles in the development of numerous organs, including the inner ear. The inner ear is a relatively small organ but has a highly complex structure and is involved in both hearing and balance. Here, we discuss BMPs and BMP signaling pathways and then focus on the role of BMP signal pathway regulation in the development of the inner ear and the implications this has for the treatment of human hearing loss and balance dysfunction.



Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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