Full Text:   <435>

Summary:  <130>

CLC number: R595.9

On-line Access: 2019-06-06

Received: 2019-01-02

Revision Accepted: 2019-03-10

Crosschecked: 2019-05-23

Cited: 0

Clicked: 687

Citations:  Bibtex RefMan EndNote GB/T7714


Yuan-qiang Lu


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Journal of Zhejiang University SCIENCE B 2019 Vol.20 No.7 P.588-597


Systematic review and meta-analysis of the efficacy and safety of immunosuppressive pulse therapy in the treatment of paraquat poisoning

Author(s):  Ying-Ge Xu, Yuan-Qiang Lu

Affiliation(s):  Department of Emergency Medicine, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China

Corresponding email(s):   luyuanqiang@zju.edu.cn

Key Words:  Paraquat, Glucocorticoids, Cyclophosphamide, Immunosuppressive pulse therapy, Meta-analysis

Ying-Ge Xu, Yuan-Qiang Lu. Systematic review and meta-analysis of the efficacy and safety of immunosuppressive pulse therapy in the treatment of paraquat poisoning[J]. Journal of Zhejiang University Science B, 2019, 20(7): 588-597.

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%A Ying-Ge Xu
%A Yuan-Qiang Lu
%J Journal of Zhejiang University SCIENCE B
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%N 7
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%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1800640

T1 - Systematic review and meta-analysis of the efficacy and safety of immunosuppressive pulse therapy in the treatment of paraquat poisoning
A1 - Ying-Ge Xu
A1 - Yuan-Qiang Lu
J0 - Journal of Zhejiang University Science B
VL - 20
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EP - 597
%@ 1673-1581
Y1 - 2019
PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B1800640

paraquat (PQ), a highly effective herbicide, is widely used worldwide. PQ poisoning can cause multiple organ failure, in which the lung is the primary target organ. After PQ poisoning, the patient mortality rate is as high as 90%, and there is currently no specific antidote. The main clinical treatment is the use of glucocorticoids and cyclophosphamide for pulse therapy, but its effectiveness and safety are still uncertain. We investigated the effectiveness and safety of immunosuppressive pulse therapy with glucocorticoids and cyclophosphamide to evaluate the treatment value in patients with acute PQ poisoning. This meta-analysis, combined with seven trials that enrolled a total of 426 patients, showed that immunosuppressive pulse therapy with glucocorticoids and cyclophosphamide for PQ poisoning significantly reduced mortality of the study group (59.3%, 134/226) compared with the control group (81.0%, 162/200). There was no significant difference of hepatitis or renal failure between the control and study groups, indicating that immunosuppressive pulse therapy was relatively safe. Several patients were reported to have leukopenia and returned to normal after 1–2 weeks without any abnormalities. Two cases of non-fatal sepsis were reported and considered to be a side effect of the immunosuppressive pulse therapy. Thus, immunosuppressive pulse therapy can efficiently reduce the mortality of PQ poisoning and it is relatively safe.


方法:我们检索了截止于2018年6月,发表在PubMed, EMBASE和Cochrane三个数据库中关于免疫抑制冲击治疗百草枯中毒患者的文献.经过筛选,最终有7篇文献符合纳入标准,总共426位病人,并采用RevMan软件进行数据分析.


Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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