Full Text:   <354>

Summary:  <104>

CLC number: R737.9

On-line Access: 2019-05-15

Received: 2019-03-29

Revision Accepted: 2019-04-05

Crosschecked: 2019-04-17

Cited: 0

Clicked: 543

Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Xiaoting Zhang

https://orcid.org/0000-0002-1328-4255

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Journal of Zhejiang University SCIENCE B 2019 Vol.20 No.5 P.381-390

10.1631/jzus.B1900163


Estrogen receptor coactivator Mediator Subunit 1 (MED1) as a tissue-specific therapeutic target in breast cancer


Author(s):  Marissa Leonard, Xiaoting Zhang

Affiliation(s):  Department of Cancer Biology, University of Cincinnati College of Medicine, 3125 Eden Avenue, Cincinnati, OH 45267, USA

Corresponding email(s):   zhangxt@ucmail.uc.edu

Key Words:  Mediator Subunit 1 (MED1), Mediator, Estrogen receptor, Breast cancer, Endocrine resistance, RNA nanotechnology


Marissa Leonard, Xiaoting Zhang. Estrogen receptor coactivator Mediator Subunit 1 (MED1) as a tissue-specific therapeutic target in breast cancer[J]. Journal of Zhejiang University Science B, 2019, 20(5): 381-390.

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T1 - Estrogen receptor coactivator Mediator Subunit 1 (MED1) as a tissue-specific therapeutic target in breast cancer
A1 - Marissa Leonard
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DOI - 10.1631/jzus.B1900163


Abstract: 
breast cancer, one of the most frequent cancer types, is a leading cause of death in women worldwide. estrogen receptor (ER) α is a nuclear hormone receptor that plays key roles in mammary gland development and breast cancer. About 75% of breast cancer cases are diagnosed as ER-positive; however, nearly half of these cancers are either intrinsically or inherently resistant to the current anti-estrogen therapies. Recent studies have identified an ER coactivator, mediator Subunit 1 (MED1)%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>mediator Subunit 1 (MED1), as a unique, tissue-specific cofactor that mediates breast cancer metastasis and treatment resistance. MED1 is overexpressed in over 50% of human breast cancer cases and co-amplifies with another important breast cancer gene, receptor tyrosine kinase HER2. Clinically, MED1 expression highly correlates with poor disease-free survival of breast cancer patients, and recent studies have reported an increased frequency of MED1 mutations in the circulating tumor cells of patients after treatment. In this review, we discuss the biochemical characterization of MED1 and its associated MED1/mediator complex, its crosstalk with HER2 in anti-estrogen resistance, breast cancer stem cell formation, and metastasis both in vitro and in vivo. Furthermore, we elaborate on the current advancements in targeting MED1 using state-of-the-art RNA nanotechnology and discuss the future perspectives as well.

乳腺癌组织特异性治疗靶标MED1

概要:在这篇综述中,我们讨论了雌激素受体共激活子转录中介体亚基1(MED1)作为独特的组织特异性辅因子在乳腺癌干细胞形成、转移和治疗抗性中的关键作用.此外,我们详细介绍了目前使用最先进的RNA纳米技术靶标MED1的成果,并提出了未来的展望.
关键词:转录中介体亚基1(MED1);中介体;雌激素受体;乳腺癌;内分泌治疗抗性;RNA纳米技术

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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