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CLC number: R730.51

On-line Access: 2019-05-15

Received: 2019-03-29

Revision Accepted: 2019-04-05

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Journal of Zhejiang University SCIENCE B 2019 Vol.20 No.5 P.373-380


Tumor immunology and immunotherapy: a journey I started from Hangzhou

Author(s):  Gen-Sheng Feng

Affiliation(s):  Department of Pathology, School of Medicine; more

Corresponding email(s):   gfeng@ucsd.edu

Key Words:  Immunotherapy, Liver cancer, Tumor immunology, 90th Anniversary

Gen-Sheng Feng. Tumor immunology and immunotherapy: a journey I started from Hangzhou[J]. Journal of Zhejiang University Science B, 2019, 20(5): 373-380.

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This short article is dedicated to the 90th Anniversary of the School of Life Sciences at Zhejiang University, China. immunotherapy of cancer is currently a hot topic in the biomedical field, and a re-search focus of my laboratory is on developing new and effective combinatorial immunotherapeutic strategies for liver cancer. Of note, my interest in immunotherapy of cancer stems from the training as an undergraduate student at Hangzhou University, China, almost 40 years ago.



Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


[1]Bard-Chapeau EA, Yuan J, Droin N, et al., 2006. Concerted functions of Gab1 and Shp2 in liver regeneration and hepatoprotection. Mol Cell Biol, 26(12):4664-4674.

[2]Bard-Chapeau EA, Li SW, Ding J, et al., 2011. Ptpn11/Shp2 acts as a tumor suppressor in hepatocellular carcinogenesis. Cancer Cell, 19(5):629-639.

[3]Chan RJ, Feng GS, 2007. PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase. Blood, 109(3):862-867.

[4]Darnell JE Jr, Kerr IM, Stark GR, 1994. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science, 264(5164):1415-1421.

[5]Ding RR, Ma ZZ, Zhang TW, et al., 1984. Studies on the cytolytic effect of SeO2 on the Ehrlich ascites tumor cells. J Hangzhou Univ, 11(2):269-271 (in Chinese).

[6]Feng GS, 2012. Conflicting roles of molecules in hepatocarcinogenesis: paradigm or paradox. Cancer Cell, 21(2):150-154.

[7]Feng GS, Taylor MW, 1989. Interferon γ-resistant mutants are defective in the induction of indoleamine 2,3-dioxygenase. Proc Natl Acad Sci USA, 86(18):7144-7148.

[8]Feng GS, Pawson T, 1994. Phosphotyrosine phosphatases with SH2 domains: regulators of signal transduction. Trends Genet, 10(2):54-58.

[9]Feng GS, Ye TX, Yang SK, 1985. Purification and characterization of human interferon-γ, Part I. Shanghai J Immunol, 5(6):335-338 (in Chinese).

[10]Feng GS, Ye TX, Yang SK, 1986. Purification and characterization of human interferon-γ. II. Further purification and studies on physicochemical properties. Chin J Microbiol Immunol, 6(2):103-106 (in Chinese).

[11]Feng GS, Gray PW, Shepard HM, et al., 1988. Antiproliferative activity of a hybrid protein between interferon-γ and tumor necrosis factor-β. Science, 241(4872):1501-1503.

[12]Feng GS, Chong K, Kumar A, et al., 1992. Identification of double-stranded RNA-binding domains in the interferon-induced double-stranded RNA-activated p68 kinase. Proc Natl Acad Sci USA, 89(12):5447-5451.

[13]Feng GS, Hui CC, Pawson T, 1993. SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases. Science, 259(5101):1607-1611.

[14]Koch CA, Anderson D, Moran MF, et al., 1991. SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins. Science, 252(5006):668-674.

[15]Lee J, Liao R, Wang GW, et al., 2017. Preventive inhibition of liver tumorigenesis by systemic activation of innate immune functions. Cell Rep, 21(7):1870-1882.

[16]Ma ZZ, Zhe SJ, Ding RR, et al., 1984. The Effect of SeO2 on immune function in Ehrlich ascites tumor-bearing mice. J Hangzhou Univ, 11(2):241-245 (in Chinese).

[17]Meurs E, Chong K, Galabru J, et al., 1990. Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon. Cell, 62(2):379-390.

[18]Qu CK, Shi ZQ, Shen R, et al., 1997. A deletion mutation in the SH2-N domain of Shp-2 severely suppresses hematopoietic cell development. Mol Cell Biol, 17(9):5499-5507.

[19]Qu CK, Yu WM, Azzarelli B, et al., 1998. Biased suppression of hematopoiesis and multiple developmental defects in chimeric mice containing Shp-2 mutant cells. Mol Cell Biol, 18(10):6075-6082.

[20]Qu CK, Nguyen S, Chen JZ, et al., 2001. Requirement of Shp-2 tyrosine phosphatase in lymphoid and hematopoietic cell development. Blood, 97(4):911-914.

[21]Velazquez L, Fellous M, Stark G R, et al., 1992. A protein tyrosine kinase in the interferon αβ signaling pathway. Cell, 70(2):313-322.

[22]Wen L, Xin B, Wu P, et al., 2019. An efficient combination immunotherapy for primary liver cancer by harmonized activation of innate and adaptive immunity in mice. Hepatology, online version of record.

[23]Zhu HH, Luo X, Zhang K, et al., 2015. Shp2 and Pten have antagonistic roles in myeloproliferation but cooperate to promote erythropoiesis in mammals. Proc Natl Acad Sci USA, 112(43):13342-13347.

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