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Bo-lun Zhou


Cai-ping Ren


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Journal of Zhejiang University SCIENCE B 2020 Vol.21 No.2 P.122-136


Roles of PTBP1 in alternative splicing, glycolysis, and oncogensis

Author(s):  Wei Zhu, Bo-lun Zhou, Li-juan Rong, Li Ye, Hong-juan Xu, Yao Zhou, Xue-jun Yan, Wei-dong Liu, Bin Zhu, Lei Wang, Xing-jun Jiang, Cai-ping Ren

Affiliation(s):  NHC Key Laboratory of Carcinogenesis (Central South University) and the Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, China

Corresponding email(s):   rencaiping@csu.edu.cn

Key Words:  Polypyrimidine tract-binding protein 1 (PTBP1), Alternative splicing, Glycolysis, M2 isoform of pyruvate kinase (PKM2), Cancer

Wei Zhu, Bo-lun Zhou, Li-juan Rong, Li Ye, Hong-juan Xu, Yao Zhou, Xue-jun Yan, Wei-dong Liu, Bin Zhu, Lei Wang, Xing-jun Jiang, Cai-ping Ren. Roles of PTBP1 in alternative splicing, glycolysis, and oncogensis[J]. Journal of Zhejiang University Science B, 2020, 21(2): 122-136.

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journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

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%A Wei Zhu
%A Bo-lun Zhou
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%A Li Ye
%A Hong-juan Xu
%A Yao Zhou
%A Xue-jun Yan
%A Wei-dong Liu
%A Bin Zhu
%A Lei Wang
%A Xing-jun Jiang
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%J Journal of Zhejiang University SCIENCE B
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%I Zhejiang University Press & Springer
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T1 - Roles of PTBP1 in alternative splicing, glycolysis, and oncogensis
A1 - Wei Zhu
A1 - Bo-lun Zhou
A1 - Li-juan Rong
A1 - Li Ye
A1 - Hong-juan Xu
A1 - Yao Zhou
A1 - Xue-jun Yan
A1 - Wei-dong Liu
A1 - Bin Zhu
A1 - Lei Wang
A1 - Xing-jun Jiang
A1 - Cai-ping Ren
J0 - Journal of Zhejiang University Science B
VL - 21
IS - 2
SP - 122
EP - 136
%@ 1673-1581
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PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B1900422

polypyrimidine tract-binding protein 1 (PTBP1) plays an essential role in splicing and is expressed in almost all cell types in humans, unlike the other proteins of the PTBP family. PTBP1 mediates several cellular processes in certain types of cells, including the growth and differentiation of neuronal cells and activation of immune cells. Its function is regulated by various molecules, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and RNA-binding proteins. PTBP1 plays roles in various diseases, particularly in some cancers, including colorectal cancer, renal cell cancer, breast cancer, and glioma. In cancers, it acts mainly as a regulator of glycolysis, apoptosis, proliferation, tumorigenesis, invasion, and migration. The role of PTBP1 in cancer has become a popular research topic in recent years, and this research has contributed greatly to the formulation of a useful therapeutic strategy for cancer. In this review, we summarize recent findings related to PTBP1 and discuss how it regulates the development of cancer cells.



Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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