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Received: 2019-08-14

Revision Accepted: 2019-11-13

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Journal of Zhejiang University SCIENCE B 2020 Vol.21 No.3 P.192-203


Roles of pattern recognition receptors in diabetic nephropathy

Author(s):  Zhi-Feng Zhou, Lei Jiang, Qing Zhao, Yu Wang, Jing Zhou, Qin-Kai Chen, Jin-Lei Lv

Affiliation(s):  The First Clinical Medical College of Nanchang University, Nanchang 330006, China; more

Corresponding email(s):   lvjinlei97@163.com

Key Words:  Diabetic nephropathy, Innate immunity, Pattern recognition receptor, Pathogenesis

Zhi-Feng Zhou, Lei Jiang, Qing Zhao, Yu Wang, Jing Zhou, Qin-Kai Chen, Jin-Lei Lv. Roles of pattern recognition receptors in diabetic nephropathy[J]. Journal of Zhejiang University Science B, 2020, 21(3): 192-203.

@article{title="Roles of pattern recognition receptors in diabetic nephropathy",
author="Zhi-Feng Zhou, Lei Jiang, Qing Zhao, Yu Wang, Jing Zhou, Qin-Kai Chen, Jin-Lei Lv",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Roles of pattern recognition receptors in diabetic nephropathy
%A Zhi-Feng Zhou
%A Lei Jiang
%A Qing Zhao
%A Yu Wang
%A Jing Zhou
%A Qin-Kai Chen
%A Jin-Lei Lv
%J Journal of Zhejiang University SCIENCE B
%V 21
%N 3
%P 192-203
%@ 1673-1581
%D 2020
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1900490

T1 - Roles of pattern recognition receptors in diabetic nephropathy
A1 - Zhi-Feng Zhou
A1 - Lei Jiang
A1 - Qing Zhao
A1 - Yu Wang
A1 - Jing Zhou
A1 - Qin-Kai Chen
A1 - Jin-Lei Lv
J0 - Journal of Zhejiang University Science B
VL - 21
IS - 3
SP - 192
EP - 203
%@ 1673-1581
Y1 - 2020
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1900490

diabetic nephropathy (DN) is currently the most common complication of diabetes. It is considered to be one of the leading causes of end-stage renal disease (ESRD) and affects many diabetic patients. The pathogenesis of DN is extremely complex and has not yet been clarified; however, in recent years, increasing evidence has shown the important role of innate immunity in DN pathogenesis. pattern recognition receptors (PRRs) are important components of the innate immune system and have a significant impact on the occurrence and development of DN. In this review, we classify PRRs into secretory, endocytic, and signal transduction PRRs according to the relationship between the PRRs and subcellular compartments. PRRs can recognize related pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs), thus triggering a series of inflammatory responses, promoting renal fibrosis, and finally causing renal impairment. In this review, we describe the proposed role of each type of PRRs in the development and progression of DN.




Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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