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CLC number: R587.1; R392.11; G353.11

On-line Access: 2020-03-05

Received: 2019-08-14

Revision Accepted: 2019-11-13

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Journal of Zhejiang University SCIENCE B 2020 Vol.21 No.3 P.192-203

10.1631/jzus.B1900490


Roles of pattern recognition receptors in diabetic nephropathy


Author(s):  Zhi-Feng Zhou, Lei Jiang, Qing Zhao, Yu Wang, Jing Zhou, Qin-Kai Chen, Jin-Lei Lv

Affiliation(s):  The First Clinical Medical College of Nanchang University, Nanchang 330006, China; more

Corresponding email(s):   lvjinlei97@163.com

Key Words:  Diabetic nephropathy, Innate immunity, Pattern recognition receptor, Pathogenesis


Zhi-Feng Zhou, Lei Jiang, Qing Zhao, Yu Wang, Jing Zhou, Qin-Kai Chen, Jin-Lei Lv. Roles of pattern recognition receptors in diabetic nephropathy[J]. Journal of Zhejiang University Science B, 2020, 21(3): 192-203.

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author="Zhi-Feng Zhou, Lei Jiang, Qing Zhao, Yu Wang, Jing Zhou, Qin-Kai Chen, Jin-Lei Lv",
journal="Journal of Zhejiang University Science B",
volume="21",
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pages="192-203",
year="2020",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1900490"
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%A Zhi-Feng Zhou
%A Lei Jiang
%A Qing Zhao
%A Yu Wang
%A Jing Zhou
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%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1900490

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T1 - Roles of pattern recognition receptors in diabetic nephropathy
A1 - Zhi-Feng Zhou
A1 - Lei Jiang
A1 - Qing Zhao
A1 - Yu Wang
A1 - Jing Zhou
A1 - Qin-Kai Chen
A1 - Jin-Lei Lv
J0 - Journal of Zhejiang University Science B
VL - 21
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EP - 203
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Y1 - 2020
PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B1900490


Abstract: 
diabetic nephropathy (DN) is currently the most common complication of diabetes. It is considered to be one of the leading causes of end-stage renal disease (ESRD) and affects many diabetic patients. The pathogenesis of DN is extremely complex and has not yet been clarified; however, in recent years, increasing evidence has shown the important role of innate immunity in DN pathogenesis. pattern recognition receptors (PRRs) are important components of the innate immune system and have a significant impact on the occurrence and development of DN. In this review, we classify PRRs into secretory, endocytic, and signal transduction PRRs according to the relationship between the PRRs and subcellular compartments. PRRs can recognize related pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs), thus triggering a series of inflammatory responses, promoting renal fibrosis, and finally causing renal impairment. In this review, we describe the proposed role of each type of PRRs in the development and progression of DN.

模式识别受体在糖尿病肾病中的作用

目的:阐述不同类型的模式识别受体(PRR)和糖尿病肾病(DN)之间的关系,以提供治疗DN的新方法和策略.
摘要:DN是目前糖尿病最常见的并发症.它被认为是终末期肾病(ESRD)的主要原因之一,并影响许多糖尿病患者.DN的发病机制极为复杂,且尚未阐明,但近年来,越来越多的证据表明先天免疫在DN发病机制中起到了重要作用.PRR是先天免疫系统的重要组成部分,对DN的发生和发展具有重要影响.在本综述中,我们根据PRR与亚细胞区室之间的关系将PRR分为分泌型、内吞型和信号转导型三种类型.PRR可以识别相关的病原体相关分子模式(PAMP)和危险相关分子模式(DAMP),从而触发一系列炎症反应,促进肾纤维化,最终导致肾功能损害.此外,我们还描述了各种类型的PRR在DN的发生和发展中的作用.

关键词:糖尿病肾病;天然免疫;模式识别受体;发病机制

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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