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Abstract: The college of Life Sciences (CLS) remains one of the most prestigious—and the oldest—colleges in zhejiang University. This special issue, which includes 16 reviews contributed by our alumni and faculties, is dedicated to mark the 90th Anniversary of CLS. The reviews provide a glimpse of current progresses in the areas of life sciences such as biochemical processes and their association with diseases (Ding et al., 2019; Hu et al., 2019; Jin et al., 2019; Nie and Yi, 2019), cancer biology (Feng, 2019; Huang et al., 2019; Leonard and Zhang, 2019; Zhu F et al., 2019), plant and environmental microbiology (Li et al., 2019; Yang et al., 2019; Zhu XR et al., 2019), cell cycle (Gao and Liu, 2019; Zhang et al., 2019), RNA biology (Gudenas et al., 2019; Luo et al., 2019), and protein structural biology (Yang and Tang, 2019).

[1]Ding HY, Xie YN, Dong Q, et al., 2019. Roles of hyaluronan in cardiovascular and nervous system disorders. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 20(5):428-436.

[2]Feng GS, 2019. Tumor immunology and immunotherapy: a journey I started from Hangzhou. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 20(5):373-380.

[3]Gao SW, Liu F, 2019. Novel insights into cell cycle regulation of cell fate determination. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 20(6):467-475.

[4]Gudenas BL, Wang J, Kuang SZ, et al., 2019. Genomic data mining for functional annotation of human long noncoding RNAs. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 20(6):476-487.

[5]Hu SY, Zhuang QQ, Qiu Y, et al., 2019. Cell models and drug discovery for mitochondrial diseases. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 20(5):449-456.

[6]Huang FT, Sun J, Zhang L, et al., 2019. Role of SIRT1 in hematologic malignancies. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 20(5):391-398.

[7]Jin LH, Fang ZP, Fan MJ, et al., 2019. Bile-ology: from bench to bedside. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 20(5):414-427.

[8]Leonard M, Zhang X, 2019. Estrogen receptor coactivator Mediator Subunit 1 (MED1) as a tissue-specific therapeutic target in breast cancer. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 20(5):381-390.

[9]Li HH, Wang YT, Wang Y, et al., 2019. Bacterial degradation of anthraquinone dyes. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 20(6):528-540.

[10]Luo J, Xiong Y, Fu PF, et al., 2019. Exosomal long non-coding RNAs: biological properties and therapeutic potential in cancer treatment. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 20(6):488-495.

[11]Nie H, Yi W, 2019. O-GlcNAcylation, a sweet link to the pathology of diseases. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 20(5):437-448.

[12]Yang JL, Fan W, Zheng SJ, 2019. Mechanisms and regulation of aluminum-induced secretion of organic acid anions from plant roots. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 20(6):513-527.

[13]Yang QF, Tang C, 2019. On the necessity of an integrative approach to understand protein structural dynamics. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 20(6):496-502.

[14]Zhu F, Zhang W, Yang T, et al., 2019. Complex roles of necroptosis in cancer. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 20(5):399-413.

[15]Zhu XR, Wang H, Sun J, et al., 2019. Pericarp and seed of litchi and longan fruits: constituent, extraction, bioactive activity, and potential utilization. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 20(6):503-512.

[16]Zhang YX, Pan WY, Chen J, 2019. p53 and its isoforms in DNA double-stranded break repair. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 20(6):457-466.