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On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
Crosschecked: 2021-01-18
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Yan ZHANG, Wenjia ZHANG, Min XIA, Zhujun XIE, Fangmei AN, Qiang ZHAN, Wenying TIAN, Tianyue ZHU. High expression of FABP4 in colorectal cancer and its clinical significance[J]. Journal of Zhejiang University Science B, 2021, 22(2): 136-145.
@article{title="High expression of FABP4 in colorectal cancer and its clinical significance",
author="Yan ZHANG, Wenjia ZHANG, Min XIA, Zhujun XIE, Fangmei AN, Qiang ZHAN, Wenying TIAN, Tianyue ZHU",
journal="Journal of Zhejiang University Science B",
volume="22",
number="2",
pages="136-145",
year="2021",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2000366"
}
%0 Journal Article
%T High expression of FABP4 in colorectal cancer and its clinical significance
%A Yan ZHANG
%A Wenjia ZHANG
%A Min XIA
%A Zhujun XIE
%A Fangmei AN
%A Qiang ZHAN
%A Wenying TIAN
%A Tianyue ZHU
%J Journal of Zhejiang University SCIENCE B
%V 22
%N 2
%P 136-145
%@ 1673-1581
%D 2021
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2000366
TY - JOUR
T1 - High expression of FABP4 in colorectal cancer and its clinical significance
A1 - Yan ZHANG
A1 - Wenjia ZHANG
A1 - Min XIA
A1 - Zhujun XIE
A1 - Fangmei AN
A1 - Qiang ZHAN
A1 - Wenying TIAN
A1 - Tianyue ZHU
J0 - Journal of Zhejiang University Science B
VL - 22
IS - 2
SP - 136
EP - 145
%@ 1673-1581
Y1 - 2021
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2000366
Abstract: ObjectiveTo investigate the relationship between the fatty acid-binding protein 4 (FABP4) and colorectal cancer (CRC).
MethodsUsing an enzyme-linked immunosorbent assay (ELISA), we measured the expression of FABP4 in plasma of 50 patients who underwent surgery for CRC from October 2017 to May 2018 and 50 healthy controls. The content of the visceral fat area (VFA) as seen with abdominal computed tomography (CT) scanning was measured by ImageJ software. The expression levels of FABP4, E-cadherin, and Snail proteins in CRC and adjacent tissues were determined by immunohistochemistry.
ResultsThe mean concentration of plasma FABP4 of CRC patients was higher than that of the control group (22.46 vs. 9.82 ng/mL; P<0.05). The concentration of plasma FABP4 was related to the tumor, node, metastatis (TNM) stage and lymph node metastasis and was independent of age, body mass index (BMI), tumor size and location, and the degree of differentiation of CRC. The concentration of plasma FABP4 was positively correlated with high VFA and lipoprotein-a (LPA) (P<0.05); but it was not correlated with total cholesterol (TG), total triglyceride (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL), or apolipoprotein AI (Apo-AI). The expression of FABP4 protein in CRC tissues was positively correlated with the degree of CRC differentiation, tumor stage, and lymph node metastasis. The level of FABP4 protein was negatively correlated with E-cadherin protein (r=-0.3292, P=0.0196) and positively correlated with Snail protein (r=0.5856, P<0.0001).
ConclusionsHigh LPA and VFA were risk factors for increased plasma FABP4 in CRC patients. FABP4 protein was highly expressed in CRC tissues and associated with TNM stage, differentiation, and lymph node metastasis of CRC. The level of FABP4 in CRC tissue was correlated with E-cadherin and Snail expression, suggesting that FABP4 may promote CRC progression related to epithelial-mesenchymal transition (EMT).
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