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Wenchuan WU


Ning PU


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Journal of Zhejiang University SCIENCE B 2021 Vol.22 No.12 P.971-984


Basophils as a potential therapeutic target in cancer

Author(s):  Jicheng ZHANG, Hanlin YIN, Qiangda CHEN, Guochao ZHAO, Wenhui LOU, Wenchuan WU, Ning PU

Affiliation(s):  Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China; more

Corresponding email(s):   npu15@fudan.edu.cn, wu.wenchuan@zs-hospital.sh.cn

Key Words:  Basophil, Cancer, Cytokine, Chemokine, Tumor microenvironment

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Jicheng ZHANG, Hanlin YIN, Qiangda CHEN, Guochao ZHAO, Wenhui LOU, Wenchuan WU, Ning PU. Basophils as a potential therapeutic target in cancer[J]. Journal of Zhejiang University Science B, 2021, 22(12): 971-984.

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author="Jicheng ZHANG, Hanlin YIN, Qiangda CHEN, Guochao ZHAO, Wenhui LOU, Wenchuan WU, Ning PU",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Basophils as a potential therapeutic target in cancer
%A Jicheng ZHANG
%A Hanlin YIN
%A Qiangda CHEN
%A Guochao ZHAO
%A Wenhui LOU
%A Wenchuan WU
%A Ning PU
%J Journal of Zhejiang University SCIENCE B
%V 22
%N 12
%P 971-984
%@ 1673-1581
%D 2021
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2100110

T1 - Basophils as a potential therapeutic target in cancer
A1 - Jicheng ZHANG
A1 - Hanlin YIN
A1 - Qiangda CHEN
A1 - Guochao ZHAO
A1 - Wenhui LOU
A1 - Wenchuan WU
A1 - Ning PU
J0 - Journal of Zhejiang University Science B
VL - 22
IS - 12
SP - 971
EP - 984
%@ 1673-1581
Y1 - 2021
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2100110

basophils, which are considered as redundant relatives of mast cells and the rarest granulocytes in peripheral circulation, have been neglected by researchers in the past decades. Previous studies have revealed their vital roles in allergic diseases and parasitic infections. Intriguingly, recent studies even reported that basophils might be associated with cancer development, as activated basophils synthesize and release a variety of cytokines and chemokines in response to cancers. However, it is still subject to debate whether basophils function as tumor-protecting or tumor-promoting components; the answer may depend on the tumor biology and the microenvironment. Herein, we reviewed the role of basophils in cancers, and highlighted some potential and promising therapeutic strategies.




Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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