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On-line Access: 2021-12-14
Received: 2021-05-09
Revision Accepted: 2021-08-16
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Development of a novel chemokine signaling-based multigene signature to predict prognosis and therapeutic response in colorectal cancer
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Xin QI, Donghui YAN, Jiachen ZUO, Rui WANG, Jiajia CHEN. Development of a novel chemokine signaling-based multigene signature to predict prognosis and therapeutic response in colorectal cancer[J]. Journal of Zhejiang University Science B, 2021, 22(12): 1053-1059.
@article{title="Development of a novel chemokine signaling-based multigene signature to predict prognosis and therapeutic response in colorectal cancer",
author="Xin QI, Donghui YAN, Jiachen ZUO, Rui WANG, Jiajia CHEN",
journal="Journal of Zhejiang University Science B",
volume="22",
number="12",
pages="1053-1059",
year="2021",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2100412"
}
%0 Journal Article
%T Development of a novel chemokine signaling-based multigene signature to predict prognosis and therapeutic response in colorectal cancer
%A Xin QI
%A Donghui YAN
%A Jiachen ZUO
%A Rui WANG
%A Jiajia CHEN
%J Journal of Zhejiang University SCIENCE B
%V 22
%N 12
%P 1053-1059
%@ 1673-1581
%D 2021
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2100412
TY - JOUR
T1 - Development of a novel chemokine signaling-based multigene signature to predict prognosis and therapeutic response in colorectal cancer
A1 - Xin QI
A1 - Donghui YAN
A1 - Jiachen ZUO
A1 - Rui WANG
A1 - Jiajia CHEN
J0 - Journal of Zhejiang University Science B
VL - 22
IS - 12
SP - 1053
EP - 1059
%@ 1673-1581
Y1 - 2021
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2100412
Abstract: colorectal cancer (CRC) is the most lethal gastrointestinal cancer in both males and females worldwide (Sung et al., 2021). Because of the high heterogeneity of tumors, robust prognostic biomarkers are urgently needed in CRC management (Koncina et al., 2020). chemokine signaling is a well-known pivotal player in immunity, inflammation, and cancer metastasis (Lacalle et al., 2017; Poeta et al., 2019; Do et al., 2020), and multiple genes involved in chemokine signaling have been demonstrated as potential prognostic biomarkers for CRC (Cabrero-De Las Heras and Martínez-Balibrea, 2018; Ottaiano et al., 2020; Yu et al., 2020). Therefore, the aim of our study was to develop a chemokine signaling-based multigene signature (CSbMgSig) that could effectively predict overall survival (OS) and therapeutic response for patients with CRC.
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