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Panpan ZHAO


Jingquan DONG


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Journal of Zhejiang University SCIENCE B 2022 Vol.23 No.3 P.258-264


Ameliorative effect of scutellarin on acute alcohol brain injury in mice

Author(s):  Tianmeng ZHANG, Kun WANG, Hui FAN, Qiankun YANG, Xiao ZHANG, Feixue LIU, Xin FENG, Yi CHEN, Daoyang TENG, Panpan ZHAO, Jingquan DONG

Affiliation(s):  Jiangsu Key Laboratory of Marine Bioresources and Environment, Co-Innovation Center of Jiangsu Marine Bio-Industry Technology, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, Jiangsu Ocean University, Lianyungang 222005, China; more

Corresponding email(s):   zhaopp19@mails.jlu.edu.cn, 2018000029@jou.edu.cn

Key Words:  Alcohol brain damage, Scutellarin, Inflammation, Oxidative stress

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Tianmeng ZHANG, Kun WANG, Hui FAN, Qiankun YANG, Xiao ZHANG, Feixue LIU, Xin FENG, Yi CHEN, Daoyang TENG, Panpan ZHAO, Jingquan DONG. Ameliorative effect of scutellarin on acute alcohol brain injury in mice[J]. Journal of Zhejiang University Science B, 2022, 23(3): 258-264.

@article{title="Ameliorative effect of scutellarin on acute alcohol brain injury in mice",
author="Tianmeng ZHANG, Kun WANG, Hui FAN, Qiankun YANG, Xiao ZHANG, Feixue LIU, Xin FENG, Yi CHEN, Daoyang TENG, Panpan ZHAO, Jingquan DONG",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Ameliorative effect of scutellarin on acute alcohol brain injury in mice
%A Tianmeng ZHANG
%A Hui FAN
%A Qiankun YANG
%A Feixue LIU
%A Daoyang TENG
%A Panpan ZHAO
%A Jingquan DONG
%J Journal of Zhejiang University SCIENCE B
%V 23
%N 3
%P 258-264
%@ 1673-1581
%D 2022
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2100763

T1 - Ameliorative effect of scutellarin on acute alcohol brain injury in mice
A1 - Tianmeng ZHANG
A1 - Kun WANG
A1 - Hui FAN
A1 - Qiankun YANG
A1 - Xiao ZHANG
A1 - Feixue LIU
A1 - Xin FENG
A1 - Yi CHEN
A1 - Daoyang TENG
A1 - Panpan ZHAO
A1 - Jingquan DONG
J0 - Journal of Zhejiang University Science B
VL - 23
IS - 3
SP - 258
EP - 264
%@ 1673-1581
Y1 - 2022
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2100763

Drinking culture has high significance in both China and the world, whether in the entertainment sector or in social occasions; according to the World Health Organization's 2018 Global Alcohol and Health Report, about 3 million people died from excessive drinking in 2016, accounting for 5.3% of the total global deaths that year. oxidative stress and inflammation are the most common pathological phenomena caused by alcohol abuse (Snyder et al., 2017). scutellarin, a kind of flavonoid, is one of the main active ingredients extracted from breviscapine. It exerts anti-inflammatory, antioxidant, and vasodilation effects, and has been used to treat cardiovascular diseases and alcoholic liver injury. Although scutellarin can effectively alleviate multi-target organ injury induced by different forms of stimulation, its protective effect on alcoholic brain injury has not been well-defined. Therefore, the present study established an acute alcohol mice brain injury model to explore the effect of scutellarin on acute alcoholic brain injury. The study was carried out based on the targets of oxidative stress and inflammation, which is of great significance for the targeted therapy of clinical alcohol diseases.




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