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On-line Access: 2024-08-27

Received: 2023-10-17

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Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Panpan ZHAO

https://orcid.org/0000-0002-2494-3148

Jingquan DONG

https://orcid.org/0000-0001-9696-9681

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Journal of Zhejiang University SCIENCE B 2022 Vol.23 No.3 P.258-264

http://doi.org/10.1631/jzus.B2100763


Ameliorative effect of scutellarin on acute alcohol brain injury in mice


Author(s):  Tianmeng ZHANG, Kun WANG, Hui FAN, Qiankun YANG, Xiao ZHANG, Feixue LIU, Xin FENG, Yi CHEN, Daoyang TENG, Panpan ZHAO, Jingquan DONG

Affiliation(s):  Jiangsu Key Laboratory of Marine Bioresources and Environment, Co-Innovation Center of Jiangsu Marine Bio-Industry Technology, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, Jiangsu Ocean University, Lianyungang 222005, China; more

Corresponding email(s):   zhaopp19@mails.jlu.edu.cn, 2018000029@jou.edu.cn

Key Words:  Alcohol brain damage, Scutellarin, Inflammation, Oxidative stress


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Tianmeng ZHANG, Kun WANG, Hui FAN, Qiankun YANG, Xiao ZHANG, Feixue LIU, Xin FENG, Yi CHEN, Daoyang TENG, Panpan ZHAO, Jingquan DONG. Ameliorative effect of scutellarin on acute alcohol brain injury in mice[J]. Journal of Zhejiang University Science B, 2022, 23(3): 258-264.

@article{title="Ameliorative effect of scutellarin on acute alcohol brain injury in mice",
author="Tianmeng ZHANG, Kun WANG, Hui FAN, Qiankun YANG, Xiao ZHANG, Feixue LIU, Xin FENG, Yi CHEN, Daoyang TENG, Panpan ZHAO, Jingquan DONG",
journal="Journal of Zhejiang University Science B",
volume="23",
number="3",
pages="258-264",
year="2022",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2100763"
}

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%A Kun WANG
%A Hui FAN
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%A Xiao ZHANG
%A Feixue LIU
%A Xin FENG
%A Yi CHEN
%A Daoyang TENG
%A Panpan ZHAO
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T1 - Ameliorative effect of scutellarin on acute alcohol brain injury in mice
A1 - Tianmeng ZHANG
A1 - Kun WANG
A1 - Hui FAN
A1 - Qiankun YANG
A1 - Xiao ZHANG
A1 - Feixue LIU
A1 - Xin FENG
A1 - Yi CHEN
A1 - Daoyang TENG
A1 - Panpan ZHAO
A1 - Jingquan DONG
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DOI - 10.1631/jzus.B2100763


Abstract: 
Drinking culture has high significance in both China and the world, whether in the entertainment sector or in social occasions; according to the World Health Organization's 2018 Global Alcohol and Health Report, about 3 million people died from excessive drinking in 2016, accounting for 5.3% of the total global deaths that year. oxidative stress and inflammation are the most common pathological phenomena caused by alcohol abuse (Snyder et al., 2017). scutellarin, a kind of flavonoid, is one of the main active ingredients extracted from breviscapine. It exerts anti-inflammatory, antioxidant, and vasodilation effects, and has been used to treat cardiovascular diseases and alcoholic liver injury. Although scutellarin can effectively alleviate multi-target organ injury induced by different forms of stimulation, its protective effect on alcoholic brain injury has not been well-defined. Therefore, the present study established an acute alcohol mice brain injury model to explore the effect of scutellarin on acute alcoholic brain injury. The study was carried out based on the targets of oxidative stress and inflammation, which is of great significance for the targeted therapy of clinical alcohol diseases.

灯盏花乙素对小鼠急性酒精性脑损伤的改善作用

概要:随着酗酒导致的死亡比例逐年增加,酒精对机体造成的伤害越来越受到重视。氧化应激和炎症是酗酒引起的最常见的病理现象。灯盏花乙素是从灯盏花中提取的黄酮类化合物。它具有抗炎症和抗氧化活性,常被用于高血压、糖尿病、神经炎等多种疾病。但是灯盏花乙素对酒精性脑损伤的是否具有保护作用尚不明确。因此,本研究基于灯盏花乙素抗炎和抗氧化这两大靶点,建立了小鼠急性酒精性脑损伤模型,并进行组织病理学观察、生化指标检测和炎性因子表达测定。结果表明,灯盏花乙素可改善脑组织损伤,并显著降低由于酒精暴露引起的IL-1βIL-6TNF-α炎症因子的异常升高,同时也显著增强SOD、CAT等抗氧化酶的活性。因此,灯盏花乙素对酒精引起的急性脑损伤具有缓解作用。

关键词:酒精性脑损伤;灯盏花乙素;炎症;氧化应激

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