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On-line Access: 2022-06-16
Received: 2022-04-24
Revision Accepted: 2022-08-18
Crosschecked: 2022-09-16
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Nanobubbles loaded with carbon quantum dots for ultrasonic fluorescence dual detection
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Yankun ZHANG, Bingtao TANG, Yu XIN, Qiong WU, Lan LIU, Yunxia WANG, Kongxi ZHU, Guimei LIN, Hongjuan WANG. Nanobubbles loaded with carbon quantum dots for ultrasonic fluorescence dual detection[J]. Journal of Zhejiang University Science B, 2022, 23(9): 778-783.
@article{title="Nanobubbles loaded with carbon quantum dots for ultrasonic fluorescence dual detection",
author="Yankun ZHANG, Bingtao TANG, Yu XIN, Qiong WU, Lan LIU, Yunxia WANG, Kongxi ZHU, Guimei LIN, Hongjuan WANG",
journal="Journal of Zhejiang University Science B",
volume="23",
number="9",
pages="778-783",
year="2022",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2200233"
}
%0 Journal Article
%T Nanobubbles loaded with carbon quantum dots for ultrasonic fluorescence dual detection
%A Yankun ZHANG
%A Bingtao TANG
%A Yu XIN
%A Qiong WU
%A Lan LIU
%A Yunxia WANG
%A Kongxi ZHU
%A Guimei LIN
%A Hongjuan WANG
%J Journal of Zhejiang University SCIENCE B
%V 23
%N 9
%P 778-783
%@ 1673-1581
%D 2022
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2200233
TY - JOUR
T1 - Nanobubbles loaded with carbon quantum dots for ultrasonic fluorescence dual detection
A1 - Yankun ZHANG
A1 - Bingtao TANG
A1 - Yu XIN
A1 - Qiong WU
A1 - Lan LIU
A1 - Yunxia WANG
A1 - Kongxi ZHU
A1 - Guimei LIN
A1 - Hongjuan WANG
J0 - Journal of Zhejiang University Science B
VL - 23
IS - 9
SP - 778
EP - 783
%@ 1673-1581
Y1 - 2022
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2200233
Abstract: To increase the efficiency and accuracy of clinical tumor detection, we explored multiple imaging by preparing carbon quantum dot (CQD)-loaded nanobubbles for ultrasonic fluorescence dual detection. In this experiment, we prepared 1,2-dioleoyl3-trimethylammonium-propane chloride (DOTAP) cationic liposomes using the film dispersion method and chose perfluoropentane as the core gas material of the nanobubbles. The nanobubbles were coupled with the negatively charged CQDs through the charge effect to prepare the testing agent for two-way diagnosis with ultrasound contrast and fluorescence detection. The formulation and preparation of the loaded CQD liposome nanobubbles were screened. In vivo experiments showed that nanobubbles can be enriched to the tumor site within 5 min, which enables clearer ultrasound imaging and is conducive to tumor detection. We expect CQD-loaded liposome (Lip-CQD) nanobubbles to become a new ultrasonic contrast agent for clinical applications that can provide a basis for early tumor diagnosis and thus earlier treatment.
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