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On-line Access: 2023-01-10

Received: 2022-04-29

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 ORCID:

Zhaolu WANG

https://orcid.org/0000-0001-6036-9668

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Journal of Zhejiang University SCIENCE B 2023 Vol.24 No.1 P.1-14

http://doi.org/10.1631/jzus.B2200243


Exosome-mediated regulatory mechanisms in skeletal muscle: a narrative review


Author(s):  Zhaolu WANG, Jinjin YANG, Xiaohui SUN, Xi SUN, Gongshe YANG, Xin'e SHI

Affiliation(s):  College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China

Corresponding email(s):   xineshi@nwafu.edu.cn

Key Words:  Exosome, Skeletal muscle, Muscle atrophy, Insulin resistance


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Zhaolu WANG, Jinjin YANG, Xiaohui SUN, Xi SUN, Gongshe YANG, Xin'e SHI. Exosome-mediated regulatory mechanisms in skeletal muscle: a narrative review[J]. Journal of Zhejiang University Science B, 2023, 24(1): 1-14.

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year="2023",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2200243"
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%A Xi SUN
%A Gongshe YANG
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%J Journal of Zhejiang University SCIENCE B
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A1 - Zhaolu WANG
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A1 - Xiaohui SUN
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DOI - 10.1631/jzus.B2200243


Abstract: 
skeletal muscle plays a paramount role in physical activity, metabolism, and energy balance, while its homeostasis is being challenged by multiple unfavorable factors such as injury, aging, or obesity. exosomes, a subset of extracellular vesicles, are now recognized as essential mediators of intercellular communication, holding great clinical potential in the treatment of skeletal muscle diseases. Herein, we outline the recent research progress in exosomal isolation, characterization, and mechanism of action, and emphatically discuss current advances in exosomes derived from multiple organs and tissues, and engineered exosomes regarding the regulation of physiological and pathological development of skeletal muscle. These remarkable advances expand our understanding of myogenesis and muscle diseases. Meanwhile, the engineered exosome, as an endogenous nanocarrier combined with advanced design methodologies of biomolecules, will help to open up innovative therapeutic perspectives for the treatment of muscle diseases.

骨骼肌中外泌体介导的调节机制:叙述性综述

王召路,杨金金,孙晓晖,孙喜,杨公社,史新娥
西北农林科技大学动物科学与技术学院,陕西杨陵,712100
概要:骨骼肌在机体活动、新陈代谢和能量平衡中发挥着至关重要的作用,而其稳态受到多种因素的挑战,例如受伤、衰老和肥胖。外泌体是细胞外囊泡的一个子集,是细胞间通讯的重要介质,在治疗骨骼肌疾病方面具有巨大临床潜力。我们通过概述外泌体提取、鉴定和功能机制的研究进展,并重点讨论来自多个器官、组织的外泌体和工程化外泌体在调节骨骼肌生理与病理发育方面的最新成果,以扩大我们对肌肉发生与肌肉疾病的理解范围。同时,工程化外泌体作为内源性纳米载体,与先进的生物分子设计方法结合后,将有助于为肌肉疾病的治疗开辟新前景。

关键词:外泌体;骨骼肌;肌肉萎缩;胰岛素抵抗

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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