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Zhaolu WANG


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Journal of Zhejiang University SCIENCE B 2023 Vol.24 No.1 P.1-14


Exosome-mediated regulatory mechanisms in skeletal muscle: a narrative review

Author(s):  Zhaolu WANG, Jinjin YANG, Xiaohui SUN, Xi SUN, Gongshe YANG, Xin'e SHI

Affiliation(s):  College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China

Corresponding email(s):   xineshi@nwafu.edu.cn

Key Words:  Exosome, Skeletal muscle, Muscle atrophy, Insulin resistance

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Zhaolu WANG, Jinjin YANG, Xiaohui SUN, Xi SUN, Gongshe YANG, Xin'e SHI. Exosome-mediated regulatory mechanisms in skeletal muscle: a narrative review[J]. Journal of Zhejiang University Science B, 2023, 24(1): 1-14.

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journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

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%T Exosome-mediated regulatory mechanisms in skeletal muscle: a narrative review
%A Zhaolu WANG
%A Jinjin YANG
%A Xiaohui SUN
%A Gongshe YANG
%A Xin'e SHI
%J Journal of Zhejiang University SCIENCE B
%V 24
%N 1
%P 1-14
%@ 1673-1581
%D 2023
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2200243

T1 - Exosome-mediated regulatory mechanisms in skeletal muscle: a narrative review
A1 - Zhaolu WANG
A1 - Jinjin YANG
A1 - Xiaohui SUN
A1 - Xi SUN
A1 - Gongshe YANG
A1 - Xin'e SHI
J0 - Journal of Zhejiang University Science B
VL - 24
IS - 1
SP - 1
EP - 14
%@ 1673-1581
Y1 - 2023
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2200243

skeletal muscle plays a paramount role in physical activity, metabolism, and energy balance, while its homeostasis is being challenged by multiple unfavorable factors such as injury, aging, or obesity. exosomes, a subset of extracellular vesicles, are now recognized as essential mediators of intercellular communication, holding great clinical potential in the treatment of skeletal muscle diseases. Herein, we outline the recent research progress in exosomal isolation, characterization, and mechanism of action, and emphatically discuss current advances in exosomes derived from multiple organs and tissues, and engineered exosomes regarding the regulation of physiological and pathological development of skeletal muscle. These remarkable advances expand our understanding of myogenesis and muscle diseases. Meanwhile, the engineered exosome, as an endogenous nanocarrier combined with advanced design methodologies of biomolecules, will help to open up innovative therapeutic perspectives for the treatment of muscle diseases.




Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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