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Qianhui LI, Hongye LU, Mengyuan ZHANG, Yuting YE, Qianming CHEN, Ping SUN. Epigenetic factors associated with peri-implantitis: a review[J]. Journal of Zhejiang University Science B, 1998, -1(-1): .
@article{title="Epigenetic factors associated with peri-implantitis: a review",
author="Qianhui LI, Hongye LU, Mengyuan ZHANG, Yuting YE, Qianming CHEN, Ping SUN",
journal="Journal of Zhejiang University Science B",
volume="-1",
number="-1",
pages="",
year="1998",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2400032"
}
%0 Journal Article
%T Epigenetic factors associated with peri-implantitis: a review
%A Qianhui LI
%A Hongye LU
%A Mengyuan ZHANG
%A Yuting YE
%A Qianming CHEN
%A Ping SUN
%J Journal of Zhejiang University SCIENCE B
%V -1
%N -1
%P
%@ 1673-1581
%D 1998
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2400032
TY - JOUR
T1 - Epigenetic factors associated with peri-implantitis: a review
A1 - Qianhui LI
A1 - Hongye LU
A1 - Mengyuan ZHANG
A1 - Yuting YE
A1 - Qianming CHEN
A1 - Ping SUN
J0 - Journal of Zhejiang University Science B
VL - -1
IS - -1
SP -
EP -
%@ 1673-1581
Y1 - 1998
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2400032
Abstract: Peri-implant diseases are conditions characterized by the resorption of hard tissue and the inflammation of soft tissue. epigenetics refers to alterations in the gene expression that are not encoded in the DNA sequence, influencing diverse physiological activities, including immune response, inflammation, and bone metabolism. Epigenetic modifications can lead to tissue-specific gene expression variations among individuals and may initiate or exacerbate inflammation and disease predisposition. However, the impact of these factors on peri-implantitis remains inconclusive. To address this gap, we conducted a comprehensive review to investigate the association between epigenetic mechanisms and peri-implantitis, specifically focusing on DNA methylation and microRNAs (miRNA, or miR). We searched for relevant literature on PubMed, Web of Science, Scopus, and Google Scholar with keywords including "epigenetics", "peri-implantitis", "DNA methylation" and "microRNA". DNA methylation and miRNAs present a dynamic epigenetic mechanism operating around implants. Epigenetic modifications of genes related to inflammation and osteogenesis provide a new perspective in understanding how local and environmental factors influence the pathogenesis of peri-implantitis. In addition, we assessed the potential application of DNA methylation and miRNAs in the prevention, diagnosis, and treatment of peri-implantitis, aiming to provide a foundation for future studies to explore potential therapeutic targets and develop more effective management strategies for this condition. The findings also have broader implications for understanding the pathogenesis of other inflammation-related oral diseases like periodontitis.
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