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Journal of Zhejiang University SCIENCE B 1998 Vol.-1 No.-1 P.

http://doi.org/10.1631/jzus.B2400186


Rescuing lysosomal/autophagic defects via nanoapproach: implications for lysosomal/autophagic defect related diseases


Author(s):  Xiaodan HUANG, Yue FANG, Jie SONG, Yuanjing HAO, Yuanyuan CAI, Pengfei WEI, Na ZHANG

Affiliation(s):  School of Pharmacy, Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment, Binzhou Medical University, Yantai 264003, China; more

Corresponding email(s):   pfwei@bzmc.edu.cn, zhangna20@bzmc.edu.cn

Key Words:  Lysosome, Autophagy, Lysosomal/autophagic disfunction, Acidic nanoparticles, Transcription factor EB, Dementia, Alzheimer’, s disease


Xiaodan HUANG, Yue FANG, Jie SONG, Yuanjing HAO, Yuanyuan CAI, Pengfei WEI, Na ZHANG. Rescuing lysosomal/autophagic defects via nanoapproach: implications for lysosomal/autophagic defect related diseases[J]. Journal of Zhejiang University Science B, 1998, -1(-1): .

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A1 - Pengfei WEI
A1 - Na ZHANG
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Abstract: 
The dysfunction of the lysosome and autophagy-lysosome system serves as a driving force for neurodegenerative diseases, metabolic disorders, inflammatory conditions, and other related diseases, closely influencing their onset and progression. Therefore, restoring the function of the lysosome or autophagy-lysosome system has become an increasingly crucial therapeutic strategy in disease management. In this article, we introduce lysosomal biogenesis, structure, and function, as well as the biological process of the autophagylysosome system. Various diseases closely associated with lysosomal/autophagic dysfunction are also reviewed, emphasizing the significance of regulating the function of the lysosome or autophagy-lysosome system in disease treatment. Finally, we focus on engineered nanomaterials that have the capabilities to restore the function of the lysosome or autophagy-lysosome system, and summarize different strategies and methods for achieving this goal. This review article aims to elucidate the latest progress in the field of nanomedicine for lysosomal/autophagic defect-related diseases and inspire the development of innovative and clinically valuable nanomedicines.

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