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Ru HE, Hongyi JIANG, Chengchi ZHANG, Yuan CHEN, Wenshun LIU, Xinyue DENG, Xiaozheng ZHU, Yunye LIU, Chuanming ZHENG, Yining ZHANG, Chengying SHAO, Yanting DUAN, Jiajie XU. CXCL16 promotes proliferation of head and neck squamous cell carcinoma by regulating GPX1-mediated antioxidant levels[J]. Journal of Zhejiang University Science B, 1998, -1(-1): .
@article{title="CXCL16 promotes proliferation of head and neck squamous cell carcinoma by regulating GPX1-mediated antioxidant levels",
author="Ru HE, Hongyi JIANG, Chengchi ZHANG, Yuan CHEN, Wenshun LIU, Xinyue DENG, Xiaozheng ZHU, Yunye LIU, Chuanming ZHENG, Yining ZHANG, Chengying SHAO, Yanting DUAN, Jiajie XU",
journal="Journal of Zhejiang University Science B",
volume="-1",
number="-1",
pages="",
year="1998",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2400192"
}
%0 Journal Article
%T CXCL16 promotes proliferation of head and neck squamous cell carcinoma by regulating GPX1-mediated antioxidant levels
%A Ru HE
%A Hongyi JIANG
%A Chengchi ZHANG
%A Yuan CHEN
%A Wenshun LIU
%A Xinyue DENG
%A Xiaozheng ZHU
%A Yunye LIU
%A Chuanming ZHENG
%A Yining ZHANG
%A Chengying SHAO
%A Yanting DUAN
%A Jiajie XU
%J Journal of Zhejiang University SCIENCE B
%V -1
%N -1
%P
%@ 1673-1581
%D 1998
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2400192
TY - JOUR
T1 - CXCL16 promotes proliferation of head and neck squamous cell carcinoma by regulating GPX1-mediated antioxidant levels
A1 - Ru HE
A1 - Hongyi JIANG
A1 - Chengchi ZHANG
A1 - Yuan CHEN
A1 - Wenshun LIU
A1 - Xinyue DENG
A1 - Xiaozheng ZHU
A1 - Yunye LIU
A1 - Chuanming ZHENG
A1 - Yining ZHANG
A1 - Chengying SHAO
A1 - Yanting DUAN
A1 - Jiajie XU
J0 - Journal of Zhejiang University Science B
VL - -1
IS - -1
SP -
EP -
%@ 1673-1581
Y1 - 1998
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2400192
Abstract: Numerous studies have demonstrated that high expression of the CXC motif chemokine ligand 16 (CXCL16) in cancer correlates with poor prognosis, as well as tumor cell proliferation, migration and invasion. While CXCL16 can serve as a tumor biomarker, the underlying mechanism in modulating head and neck squamous carcinoma (HNSCC) remains unclear. In this study, we aimed to investigate CXCL16 expression in head and neck squamous carcinoma and uncover the potential underlying mechanism. We determined the high expression of CXCL16 in The Cancer Genome Atlas (TCGA) database, tissue samples from patients with head and neck squamous cell carcinoma at our central hospital and from HNSCC cell lines. The results showed that CXCL16 knockdown inhibited the proliferation, migration and invasion of HNSCC cells. Mechanistically, transcriptome sequencing revealed that CXCL16 may affect HNSCC cell growth by regulating the antioxidant pathway of glutathione peroxidase 1 (GPX1). ROS levels were elevated in si-CXCL16 cells, which may contribute to the inhibition of cell proliferation, migration and invasion. Moreover, treatment of cells with the GPX1 inhibitor eldecalcitol (ED-71) revealed that HNSCC cell growth was significantly inhibited in the synergistic group of si-CXCL16 and GPX1 inhibitor compared to the si-CXCL16 group. In conclusion, CXCL16 contributed to the development of HNSCC cells by modulating the GPX1-mediated antioxidant pathway. Thus, targeting cellular CXCL16 expression seems a promising strategy for treating head and neck squamous cell carcinoma.
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