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Pediatric inflammatory bowel disease in mother-child pairs: clinical risk factors and gut microbiota characteristics
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Cunzheng ZHANG, Ruqiao DUAN, Nini DAI, Yuzhu CHEN, Gaonan LI, Xiaoang LI, Xiaolin JI, Xuemei ZHONG, Zailing LI, Liping DUAN. Pediatric inflammatory bowel disease in mother-child pairs: clinical risk factors and gut microbiota characteristics[J]. Journal of Zhejiang University Science B, 1998, -1(-1): .
@article{title="Pediatric inflammatory bowel disease in mother-child pairs: clinical risk factors and gut microbiota characteristics",
author="Cunzheng ZHANG, Ruqiao DUAN, Nini DAI, Yuzhu CHEN, Gaonan LI, Xiaoang LI, Xiaolin JI, Xuemei ZHONG, Zailing LI, Liping DUAN",
journal="Journal of Zhejiang University Science B",
volume="-1",
number="-1",
pages="",
year="1998",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2400330"
}
%0 Journal Article
%T Pediatric inflammatory bowel disease in mother-child pairs: clinical risk factors and gut microbiota characteristics
%A Cunzheng ZHANG
%A Ruqiao DUAN
%A Nini DAI
%A Yuzhu CHEN
%A Gaonan LI
%A Xiaoang LI
%A Xiaolin JI
%A Xuemei ZHONG
%A Zailing LI
%A Liping DUAN
%J Journal of Zhejiang University SCIENCE B
%V -1
%N -1
%P
%@ 1673-1581
%D 1998
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2400330
TY - JOUR
T1 - Pediatric inflammatory bowel disease in mother-child pairs: clinical risk factors and gut microbiota characteristics
A1 - Cunzheng ZHANG
A1 - Ruqiao DUAN
A1 - Nini DAI
A1 - Yuzhu CHEN
A1 - Gaonan LI
A1 - Xiaoang LI
A1 - Xiaolin JI
A1 - Xuemei ZHONG
A1 - Zailing LI
A1 - Liping DUAN
J0 - Journal of Zhejiang University Science B
VL - -1
IS - -1
SP -
EP -
%@ 1673-1581
Y1 - 1998
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2400330
Abstract: Objective: The risk factors and the role of mother-child gut microbiota in pediatric inflammatory bowel disease (PIBD) remain unclear. We aimed to explore the clinical risk factors associated with PIBD, analyze the gut microbiota characteristics of children and their mothers, and examine the correlation of microbial composition in mother-child pairs. Methods: We conducted a case-control study including children with PIBD and their mothers as the case group, as well as healthy children and their mothers as the control group. Questionnaires were used to collect information such as family illness history, and maternal and early-life events. Fecal samples were collected from the children and mothers for microbiota 16S rRNA sequencing, to analyze the composition and its potential association with PIBD. Results: A total of 54 pairs of cases and 122 pairs of controls were recruited. A family history of autoimmune disease and antibiotic use during pregnancy were associated with an increased risk of PIBD, and a higher education level of the father was associated with a decreased risk of PIBD. Children with IBD and mothers exhibited different gut microbiota compared to healthy children and mothers. Similarity was observed in the gut microbiota of mothers and children in the same groups. Some bacterial biomarkers of mothers discovered in this study had the power to predict PIBD in their offspring. Conclusion: PIBD is influenced by maternal risk factors and has unique gut microbiota characteristics. Mother-child gut microbiota are closely related, suggesting transmission and influence of gut microbiota between mothers and children. This study provides a potential pathogenesis of PIBD and a basis for developing targeted interventions.
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