Full Text:   <107>

CLC number: 

On-line Access: 2024-08-27

Received: 2023-10-17

Revision Accepted: 2024-05-08

Crosschecked: 0000-00-00

Cited: 0

Clicked: 123

Citations:  Bibtex RefMan EndNote GB/T7714

-   Go to

Article info.
Open peer comments

Journal of Zhejiang University SCIENCE B 1998 Vol.-1 No.-1 P.

http://doi.org/10.1631/jzus.B2400341


Metapangenomics reveals an increased proportion of an Escherichia coli-dominated enterotype in older Chinese people


Author(s):  Jinyou LI, Yue WU, Yichen YANG, Lufang CHEN, Caihong HE, Shixian ZHOU, Shunmei HUANG, Xia ZHANG, Yuming WANG, Qifeng GUI, Haifeng LU, Qin ZHANG, and Yunmei YANG

Affiliation(s):  Key Laboratory of Diagnosis and Treatment of Aging and Physic-chemical Injury Diseases of Zhejiang Province, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China; more

Corresponding email(s):   1194070@zju.edu.cn, zhangqin1978@zju.edu.cn

Key Words:  Gut microbiome, Aging, Elderly population, Escherichia-dominated enterotype, Enterotype, Escherichia coli


Jinyou LI, Yue WU, Yichen YANG, Lufang CHEN, Caihong HE, Shixian ZHOU, Shunmei HUANG, Xia ZHANG, Yuming WANG, Qifeng GUI, Haifeng LU, Qin ZHANG, and Yunmei YANG. Metapangenomics reveals an increased proportion of an Escherichia coli-dominated enterotype in older Chinese people[J]. Journal of Zhejiang University Science B, 1998, -1(-1): .

@article{title="Metapangenomics reveals an increased proportion of an Escherichia coli-dominated enterotype in older Chinese people",
author="Jinyou LI, Yue WU, Yichen YANG, Lufang CHEN, Caihong HE, Shixian ZHOU, Shunmei HUANG, Xia ZHANG, Yuming WANG, Qifeng GUI, Haifeng LU, Qin ZHANG, and Yunmei YANG",
journal="Journal of Zhejiang University Science B",
volume="-1",
number="-1",
pages="",
year="1998",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2400341"
}

%0 Journal Article
%T Metapangenomics reveals an increased proportion of an Escherichia coli-dominated enterotype in older Chinese people
%A Jinyou LI
%A Yue WU
%A Yichen YANG
%A Lufang CHEN
%A Caihong HE
%A Shixian ZHOU
%A Shunmei HUANG
%A Xia ZHANG
%A Yuming WANG
%A Qifeng GUI
%A Haifeng LU
%A Qin ZHANG
%A and Yunmei YANG
%J Journal of Zhejiang University SCIENCE B
%V -1
%N -1
%P
%@ 1673-1581
%D 1998
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2400341

TY - JOUR
T1 - Metapangenomics reveals an increased proportion of an Escherichia coli-dominated enterotype in older Chinese people
A1 - Jinyou LI
A1 - Yue WU
A1 - Yichen YANG
A1 - Lufang CHEN
A1 - Caihong HE
A1 - Shixian ZHOU
A1 - Shunmei HUANG
A1 - Xia ZHANG
A1 - Yuming WANG
A1 - Qifeng GUI
A1 - Haifeng LU
A1 - Qin ZHANG
A1 - and Yunmei YANG
J0 - Journal of Zhejiang University Science B
VL - -1
IS - -1
SP -
EP -
%@ 1673-1581
Y1 - 1998
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2400341


Abstract: 
It is likely that gut microbial communities are remodeled in tandem with accumulated physiological decline during aging, yet there is limited understanding of gut microbiome variation in advanced age. Here, we performed a metagenomics-based enterotype analysis in a geographically homogeneous cohort of 367 enrolled Chinese individuals between the ages of 60 and 94, with the goal of characterizing the gut microbiome of the older individuals and identifying factors linked to enterotype variations. In addition to two adult-like enterotypes dominated by Bacteroides (ET-Bacteroides) and Prevotella (ET- Prevotella), we identified a novel enterotype dominated by Escherichia coli (ET- Escherichia), whose prevalence increased in advanced age. Our data demonstrated that age explained more of the variance in the gut microbiome than previously identified factors such as type 2 diabetes mellitus (T2DM) or diet. We characterized the distinct taxonomic and functional profile of ET- Escherichia, and found the strongest cohesion and highest robustness of the microbial co-occurrence network in this enterotype, as well as the lowest species diversity. In addition, we carried out a series of correlation analyses and co-abundance network analyses which showed that several factors were likely linked to the overabundance of Escherichia members, including advanced age, vegetable intake, and fruit intake. Overall, our data revealed an enterotype variation characterized by E. coli enrichment in the elderly population. Considering the different age distribution of each enterotype, these findings provide new insights into the changes that occur in the gut microbiome with age and highlight the importance of microbiome-based stratification of older individuals.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Open peer comments: Debate/Discuss/Question/Opinion

<1>

Please provide your name, email address and a comment





Journal of Zhejiang University-SCIENCE, 38 Zheda Road, Hangzhou 310027, China
Tel: +86-571-87952783; E-mail: cjzhang@zju.edu.cn
Copyright © 2000 - 2024 Journal of Zhejiang University-SCIENCE