CLC number:
On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
Crosschecked: 0000-00-00
Cited: 0
Clicked: 123
Jinyou LI, Yue WU, Yichen YANG, Lufang CHEN, Caihong HE, Shixian ZHOU, Shunmei HUANG, Xia ZHANG, Yuming WANG, Qifeng GUI, Haifeng LU, Qin ZHANG, and Yunmei YANG. Metapangenomics reveals an increased proportion of an Escherichia coli-dominated enterotype in older Chinese people[J]. Journal of Zhejiang University Science B, 1998, -1(-1): .
@article{title="Metapangenomics reveals an increased proportion of an Escherichia coli-dominated enterotype in older Chinese people",
author="Jinyou LI, Yue WU, Yichen YANG, Lufang CHEN, Caihong HE, Shixian ZHOU, Shunmei HUANG, Xia ZHANG, Yuming WANG, Qifeng GUI, Haifeng LU, Qin ZHANG, and Yunmei YANG",
journal="Journal of Zhejiang University Science B",
volume="-1",
number="-1",
pages="",
year="1998",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2400341"
}
%0 Journal Article
%T Metapangenomics reveals an increased proportion of an Escherichia coli-dominated enterotype in older Chinese people
%A Jinyou LI
%A Yue WU
%A Yichen YANG
%A Lufang CHEN
%A Caihong HE
%A Shixian ZHOU
%A Shunmei HUANG
%A Xia ZHANG
%A Yuming WANG
%A Qifeng GUI
%A Haifeng LU
%A Qin ZHANG
%A and Yunmei YANG
%J Journal of Zhejiang University SCIENCE B
%V -1
%N -1
%P
%@ 1673-1581
%D 1998
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2400341
TY - JOUR
T1 - Metapangenomics reveals an increased proportion of an Escherichia coli-dominated enterotype in older Chinese people
A1 - Jinyou LI
A1 - Yue WU
A1 - Yichen YANG
A1 - Lufang CHEN
A1 - Caihong HE
A1 - Shixian ZHOU
A1 - Shunmei HUANG
A1 - Xia ZHANG
A1 - Yuming WANG
A1 - Qifeng GUI
A1 - Haifeng LU
A1 - Qin ZHANG
A1 - and Yunmei YANG
J0 - Journal of Zhejiang University Science B
VL - -1
IS - -1
SP -
EP -
%@ 1673-1581
Y1 - 1998
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2400341
Abstract: It is likely that gut microbial communities are remodeled in tandem with accumulated physiological decline during aging, yet there is limited understanding of gut microbiome variation in advanced age. Here, we performed a metagenomics-based enterotype analysis in a geographically homogeneous cohort of 367 enrolled Chinese individuals between the ages of 60 and 94, with the goal of characterizing the gut microbiome of the older individuals and identifying factors linked to enterotype variations. In addition to two adult-like enterotypes dominated by Bacteroides (ET-Bacteroides) and Prevotella (ET- Prevotella), we identified a novel enterotype dominated by Escherichia coli (ET- Escherichia), whose prevalence increased in advanced age. Our data demonstrated that age explained more of the variance in the gut microbiome than previously identified factors such as type 2 diabetes mellitus (T2DM) or diet. We characterized the distinct taxonomic and functional profile of ET- Escherichia, and found the strongest cohesion and highest robustness of the microbial co-occurrence network in this enterotype, as well as the lowest species diversity. In addition, we carried out a series of correlation analyses and co-abundance network analyses which showed that several factors were likely linked to the overabundance of Escherichia members, including advanced age, vegetable intake, and fruit intake. Overall, our data revealed an enterotype variation characterized by E. coli enrichment in the elderly population. Considering the different age distribution of each enterotype, these findings provide new insights into the changes that occur in the gut microbiome with age and highlight the importance of microbiome-based stratification of older individuals.
Open peer comments: Debate/Discuss/Question/Opinion
<1>