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CLC number: R542.2

On-line Access: 2013-07-30

Received: 2013-07-01

Revision Accepted: 2013-07-12

Crosschecked: 2013-07-01

Cited: 2

Clicked: 4105

Citations:  Bibtex RefMan EndNote GB/T7714

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Journal of Zhejiang University SCIENCE B 2013 Vol.14 No.8 P.749-753

http://doi.org/10.1631/jzus.BQICC708


Correlation between virus persistent infection and cardic function in patients with dilated cardiomyopathy


Author(s):  Qiang Liu, Xiao-jia Su, Yan Yu, Yong-lin Liu

Affiliation(s):  Department of Cardiology, the First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310006, China; more

Corresponding email(s):   LQ_925@163.com

Key Words:  Dilated cardiomyopathy, Persistent viral infection, Coxsackie adenovirus receptor, Heart function, Brain natriuretic peptide


Qiang Liu, Xiao-jia Su, Yan Yu, Yong-lin Liu. Correlation between virus persistent infection and cardic function in patients with dilated cardiomyopathy[J]. Journal of Zhejiang University Science B, 2013, 14(8): 749-753.

@article{title="Correlation between virus persistent infection and cardic function in patients with dilated cardiomyopathy",
author="Qiang Liu, Xiao-jia Su, Yan Yu, Yong-lin Liu",
journal="Journal of Zhejiang University Science B",
volume="14",
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pages="749-753",
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doi="10.1631/jzus.BQICC708"
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%T Correlation between virus persistent infection and cardic function in patients with dilated cardiomyopathy
%A Qiang Liu
%A Xiao-jia Su
%A Yan Yu
%A Yong-lin Liu
%J Journal of Zhejiang University SCIENCE B
%V 14
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%P 749-753
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%D 2013
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.BQICC708

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T1 - Correlation between virus persistent infection and cardic function in patients with dilated cardiomyopathy
A1 - Qiang Liu
A1 - Xiao-jia Su
A1 - Yan Yu
A1 - Yong-lin Liu
J0 - Journal of Zhejiang University Science B
VL - 14
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SP - 749
EP - 753
%@ 1673-1581
Y1 - 2013
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.BQICC708


Abstract: 
In our study, 50 patients with dilated cardiomyopathy (DCM) were selected to investigate the correlation between virus persistent infection and cardic function. We found that 44% of patients with DCM were coxsackie virus B-RNA (CVB-RNA) positive, significantly different from that (20%) of the normal control group (P<0.05). The expression levels of coxsackie adenovirus receptor (CAR) in patients with DCM were significantly higher than those in the normal control group (P<0.01). In CVB-RNA-positive patients, expression levels of CAR were significantly higher than those in CVB-RNA-negative patients (P<0.01). There was a positive correlation between CAR expression and brain natriuretic peptide (BNP) level in patients with DCM, but no significant correlations between the CAR expression level and left ventricular ejection fraction (LVEF) or left ventricular end diastolic diameter (LVEDd). These results showed that expression levels of CAR on the surface of white cells can be used as an indicator for detecting persistent virus infection. We found that expression levels of CAR and heart function in patients with DCM were highly correlated.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference

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