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Journal of Zhejiang University SCIENCE B 2013 Vol.14 No.8 P.676-687

10.1631/jzus.BQICC711


Advances in monoclonal antibody application in myocarditis


Author(s):  Li-na Han, Shuang He, Yu-tang Wang, Li-ming Yang, Si-yu Liu, Ting Zhang

Affiliation(s):  Department of Cardiovascular Internal Medicine, Nanlou Branch of Chinese PLA General Hospital, Beijing 100853, China

Corresponding email(s):   wangytang@sina.cn

Key Words:  Monoclonal antibody, Myocarditis, Dilated cardiomyopathy


Li-na Han, Shuang He, Yu-tang Wang, Li-ming Yang, Si-yu Liu, Ting Zhang. Advances in monoclonal antibody application in myocarditis[J]. Journal of Zhejiang University Science B, 2013, 14(8): 676-687.

@article{title="Advances in monoclonal antibody application in myocarditis",
author="Li-na Han, Shuang He, Yu-tang Wang, Li-ming Yang, Si-yu Liu, Ting Zhang",
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pages="676-687",
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%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.BQICC711

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T1 - Advances in monoclonal antibody application in myocarditis
A1 - Li-na Han
A1 - Shuang He
A1 - Yu-tang Wang
A1 - Li-ming Yang
A1 - Si-yu Liu
A1 - Ting Zhang
J0 - Journal of Zhejiang University Science B
VL - 14
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SP - 676
EP - 687
%@ 1673-1581
Y1 - 2013
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.BQICC711


Abstract: 
Monoclonal antibodies have become a part of daily preparation technologies in many laboratories. Attempts have been made to apply monoclonal antibodies to open a new train of thought for clinical treatments of autoimmune diseases, inflammatory diseases, cancer, and other immune-associated diseases. This paper is a prospective review to anticipate that monoclonal antibody application in the treatment of myocarditis, an inflammatory disease of the heart, could be a novel approach in the future. In order to better understand the current state of the art in monoclonal antibody techniques and advance applications in myocarditis, we, through a significant amount of literature research both domestic and abroad, developed a systematic elaboration of monoclonal antibodies, pathogenesis of myocarditis, and application of monoclonal antibodies in myocarditis. This paper presents review of the literature of some therapeutic aspects of monoclonal antibodies in myocarditis and dilated cardiomyopathy to demonstrate the advance of monoclonal antibody application in myocarditis and a strong anticipation that monoclonal antibody application may supply an effective therapeutic approach to relieve the severity of myocarditis in the future. Under conventional therapy, myocarditis is typically associated with congestive heart failure as a progressive outcome, indicating the need for alternative therapeutic strategies to improve long-term results. Reviewing some therapeutic aspects of monoclonal antibodies in myocarditis, we recently found that monoclonal antibodies with high purity and strong specificity can accurately act on target and achieve definite progress in the treatment of viral myocarditis in rat model and may meet the need above. However, several issues remain. The technology on how to make a higher homologous and weak immunogenic humanized or human source antibody and the treatment mechanism of monoclonal antibodies may provide solutions for these open issues. If we are to further stimulate progress in the area of clinical decision support, we must continue to develop and refine our understanding and use of monoclonal antibodies in myocarditis.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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