CLC number: R945
On-line Access: 2019-03-01
Received: 2018-06-22
Revision Accepted: 2018-10-14
Crosschecked: 2019-01-10
Cited: 0
Clicked: 6142
Su-fang Gu, Li-ying Wang, Ying-jie Tian, Zhu-xian Zhou, Jian-bin Tang, Xiang-rui Liu, Hai-ping Jiang, You-qing Shen. Enhanced water solubility, antioxidant activity, and oral absorption of hesperetin by @article{title="Enhanced water solubility, antioxidant activity, and oral absorption of hesperetin by %0 Journal Article TY - JOUR
高水溶性、抗氧化活性和口服吸收率的橙皮素纳米制剂的制备创新点:本研究使用美国食品药品监督管理局(US FDA)批准的辅料制备了两种纳米制剂:橙皮素-TPGS胶束和橙皮素-PC复合物.不仅制备方法简单,而且能显著提高橙皮素的水溶性、抗氧化活性和口服吸收率. 方法:本研究使用溶剂分散法制备纳米制剂.将橙皮素与分散剂溶于有机溶剂中,在40 °C下搅拌30 min,然后旋转蒸发除去溶剂,用水复溶即得橙皮素-TPGS胶束和橙皮素-PC复合物.本研究使用差示扫描量热法表征纳米制剂的热效应;用动态光散射法测定纳米制剂的粒径;用噻唑蓝(MTT)法检测纳米制剂的细胞毒性;用细胞抗氧化活性测定法对比纳米制剂与橙皮素本身的抗氧化活性;使用灌胃法评估纳米制剂的口服吸收效果. 结论:研究结果发现:以质量比1:12制备的橙皮素-TPGS胶束和橙皮素-PC复合物,其粒径分别为26.19和219.15 nm,没有明显的细胞毒性,同时能够将橙皮素的水溶性分别提高到21.5和20.7倍,抗氧化活性分别提高到4.2和3.9倍,口服生物利用分别提高到16.2和18.0倍.因此,这两种纳米制剂在药剂和保健品制造方面具有重要的应用价值. 关键词组: Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article
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