JZUS - Journal of Zhejiang University SCIENCE

Journal of Zhejiang University SCIENCE B

Accepted manuscript available online (unedited version)

Peripheral nerve injury in patients exposed to n-hexane: an analysis of eight cases

Author(s): Xiaping ZHANG, Yaling TONG, Yuanqiang LU
Affiliation(s): Department of Emergency Medicine, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China; more
Corresponding email(s): luyuanqiang@zju.edu.cn
Key Words:

Share this article to： More <<< Previous Paper \|

Xiaping ZHANG, Yaling TONG, Yuanqiang LU. Peripheral nerve injury in patients exposed to n-hexane: an analysis of eight cases[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B2000601

@article{title="Peripheral nerve injury in patients exposed to n-hexane: an analysis of eight cases",
author="Xiaping ZHANG, Yaling TONG, Yuanqiang LU",
journal="Journal of Zhejiang University Science B",
year="in press",
publisher="Zhejiang University Press & Springer",
doi="https://doi.org/10.1631/jzus.B2000601"
}

%0 Journal Article
%T Peripheral nerve injury in patients exposed to n-hexane: an analysis of eight cases
%A Xiaping ZHANG
%A Yaling TONG
%A Yuanqiang LU
%J Journal of Zhejiang University SCIENCE B
%P 248-252
%@ 1673-1581
%D in press
%I Zhejiang University Press & Springer
doi="https://doi.org/10.1631/jzus.B2000601"

TY - JOUR
T1 - Peripheral nerve injury in patients exposed to n-hexane: an analysis of eight cases
A1 - Xiaping ZHANG
A1 - Yaling TONG
A1 - Yuanqiang LU
J0 - Journal of Zhejiang University Science B
SP - 248
EP - 252
%@ 1673-1581
Y1 - in press
PB - Zhejiang University Press & Springer
ER -
doi="https://doi.org/10.1631/jzus.B2000601"

Abstract
Chinese Summary
Academic Network
Reviewer Comment

Abstract: Poisoning is often characterized by the acute onset, rapid progress, or specific manifestations of pathological symptoms, such as pulmonary fibrosis due to paraquat poisoning or high mortality arising from dinitrophenol intoxication (Jiang et al., 2016; Wang et al., 2017; Feng et al., 2018; Lu, 2018; Xu and Lu, 2019). Unlike general poisoning, however, the manifestation of n-hexane intoxication is subacute, and its clinical symptoms are dormant, and thus the provision of a timely and correct diagnosis is often difficult.

正己烷中毒致周围神经病变的八例临床分析

目的：探讨亚急性正己烷中毒引起的周围神经病的临床特征、诊断和及治疗。
创新点：亚急性正己烷中毒主要表现为多发性周围神经病，其特点为隐匿性、潜伏期较长、易造成误诊。根据我们一系列病例分析，我们建议医生在遇到有运动和感觉功能障碍临床表现的患者时，除了考虑神经系统疾病外，还应考虑正己烷中毒的可能性。此外，病人的职业也是正确诊断不可忽视的信息。
方法：回顾分析职业性亚急性正己烷中毒患者八例，大多表现为行动无力和四肢麻木。所有患者都曾在当地医院接受过治疗，而误诊率高达87.5%（7/8）。因正己烷无特殊解毒剂，通过皮质激素、神经营养药物等支持性治疗，以及康复训练和针灸治疗后，患者大多预后良好，神经电生理有所改善。
结论：正己烷中毒可引起周围神经受损症状，患者电生理表现明显异常，经积极治疗后，其临床预后良好。

关键词组：正己烷；中毒；神经肌电图

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference

[1]DeCaprioAP, KinneyEA, LoPachinRM, 2009. Comparative covalent protein binding of 2,‍‍5-hexanedione and 3-acetyl-2,‍‍5-hexanedione in the rat. J Toxicol Environ Health A, 72(14):861-869.

[2]FengMX, LiYN, RuanWS, et al., 2018. Predictive value of the maximum serum creatinine value and growth rate in acute paraquat poisoning patients. Sci Rep, 8:11587.

[3]JiangJK, FangW, GuLH, et al., 2016. Early changes of peripheral blood lymphocyte subpopulations in patients with occupational 2,‍4-dinitrophenol poisoning. Biomed Environ Sci, 29(12):909-914.

[4]LoPachinRM, DeCaprioAP, 2004. γ-Diketone neuropathy: axon atrophy and the role of cytoskeletal protein adduction. Toxicol Appl Pharmacol, 199(1):20-34.

[5]LoPachinRM, RossJF, ReidML, et al., 2002. Neurological evaluation of toxic axonopathies in rats: acrylamide and 2,‍5-hexanedione. Neurotoxicology, 23(1):95-110.

[6]LoPachinRM, JortnerBS, ReidML, et al., 2003. γ-Diketone central neuropathy: quantitative morphometric analysis of axons in rat spinal cord white matter regions and nerve roots. Toxicol Appl Pharmacol, 193(1):29-46.

[7]LuYQ, 2018. HIV and paraquat poisoning: fighting fire with fire? J Zhejiang Univ-Sci B (Biomed & Biotechnol), 19(2):168-170.

[8]OpanashukLA, HeDK, LehningEJ, et al., 2001. γ-Diketone peripheral neuropathy: III. Neurofilament gene expression. NeuroToxicology, 22(2):215-220.

[9]PanJH, PengCY, LoCT, et al., 2017. n-Hexane intoxication in a Chinese medicine pharmaceutical plant: a case report. J Med Case Rep, 11:120.

[10]PannangrongW, SirichoatA, WongsiriT, et al., 2019. Valproic acid withdrawal ameliorates impairments of hippocampal-spatial working memory and neurogenesis. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 20(3):253-263.

[11]PastoreC, IzuraV, MarhuendaD, et al., 2002. Partial conduction blocks in n-hexane neuropathy. Muscle Nerve, 26(1):132-135.

[12]PrietoMJ, MarhuendaD, RoelJ, et al., 2003. Free and total 2,5-hexanedione in biological monitoring of workers exposed to n-hexane in the shoe industry. Toxicol Lett, 145(3):249-260.

[13]Public Health England, 2016. n-Hexane incident management. https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/566787/n-hexane_incident_management.pdf [Accessed on Nov. 25, 2020].

[14]SendurOF, TuranY, BalS, et al., 2009. Toxic neuropathy due to n-hexane: report of three cases. Inhal Toxicol, 21(3):210-214.

[15]WangC, ChenSJ, WangZT, 2014. Electrophysiological follow-up of patients with chronic peripheral neuropathy induced by occupational intoxication with n-hexane. Cell Biochem Biophys, 70(1):579-585.

[16]WangHR, PanJ, ShangAD, et al., 2017. Time-dependent haemoperfusion after acute paraquat poisoning. Sci Rep, 7:2239.

[17]XiaLH, YanYJ, 2018. Interpretation of clinic pathway for occupational chronic n-hexane poisoning. J Chin Res Hosp, 5(4):66-71 (in Chinese).

[18]XuYG, LuYQ, 2019. Systematic review and meta-analysis of the efficacy and safety of immunosuppressive pulse therapy in the treatment of paraquat poisoning. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 20(7):588-597.

Open peer comments: Debate/Discuss/Question/Opinion

<1>

- Go to

正己烷中毒致周围神经病变的八例临床分析

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference