CLC number:
On-line Access: 2022-02-17
Received: 2021-05-10
Revision Accepted: 2021-09-07
Crosschecked: 0000-00-00
Cited: 0
Clicked: 2879
Zhiling FU, Jin ZHANG. Molecular hydrogen is a promising therapeutic agent for pulmonary disease[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B2100420 @article{title="Molecular hydrogen is a promising therapeutic agent for pulmonary disease", %0 Journal Article TY - JOUR
分子氢--一种具有广泛应用前景的肺部疾病治疗剂关键词组: Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article
Reference[1]AkagiJ, 2018. Immunological effect of hydrogen gas—hydrogen gas improves clinical outcomes of cancer patients. Gan To Kagaku Ryoho, 45(10):1475-1478 (in Japanese). [2]AkagiJ, BabaH, 2020. Hydrogen gas activates coenzyme Q10 to restore exhausted CD8+ T cells, especially PD-1+Tim3+terminal CD8+ T cells, leading to better nivolumab outcomes in patients with lung cancer. Oncol Lett, 20:258. [3]AkiraS, HemmiH, 2003. Recognition of pathogen-associated molecular patterns by TLR family. Immunol Lett, 85(2):85-95. [4]AnderssonU, YangH, HarrisH, 2018. Extracellular HMGB1 as a therapeutic target in inflammatory diseases. Exp Opin Ther Targets, 22(3):263-277. [5]AsadaR, SaitohY, MiwaN, 2019. Effects of hydrogen-rich water bath on visceral fat and skin blotch, with boiling-resistant hydrogen bubbles. Med Gas Res, 9(2):68-73. [6]AsadaR, TazawaK, SatoS, et al., 2020. Effects of hydrogen-rich water prepared by alternating-current-electrolysis on antioxidant activity, DNA oxidative injuries, and diabetes-related markers. Med Gas Res, 10(3):114-121. [7]BaiCX, FukudaN, SongYL, et al., 1999. Lung fluid transport in aquaporin-1 and aquaporin-4 knockout mice. J Clin Invest, 103(4):555-561. [8]BaiY, TaoXN, 2021. Comparison of COVID-19 and influenza characteristics. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 22(2):87-98. [9]BarstRJ, McGoonMD, ElliottCG, et al., 2012. Survival in childhood pulmonary arterial hypertension: insights from the registry to evaluate early and long-term pulmonary arterial hypertension disease management. Circulation, 125(1):113-122. [10]BenzaRL, MillerDP, BarstRJ, et al., 2012. An evaluation of long-term survival from time of diagnosis in pulmonary arterial hypertension from the REVEAL Registry. Chest, 142(2):448-456. [11]BhattacharyaJ, MatthayMA, 2013. Regulation and repair of the alveolar-capillary barrier in acute lung injury. Annu Rev Phys, 75:593-615. [12]BianYX, QinC, XinY, et al., 2018. iTRAQ-based quantitative proteomic analysis of lungs in murine polymicrobial sepsis with hydrogen gas treatment. Shock, 49(2):187-195. [13]BirbenE, SahinerUM, SackesenC, et al., 2012. Oxidative stress and antioxidant defense. World Allergy Organ J, 5(1):9-19. [14]BuchholzBM, KaczorowskiDJ, SugimotoR, et al., 2008. Hydrogen inhalation ameliorates oxidative stress in transplantation induced intestinal graft injury. Am J Transplant, 8(10):2015-2024. [15]BuschR, HobbsBD, ZhouJ, et al., 2017. Genetic association and risk scores in a chronic obstructive pulmonary disease meta-analysis of 16,707 subjects. Am J Respir Cell Mol Biol, 57(1):35-46. [16]CaiWW, ZhangMH, YuYS, et al., 2013. Treatment with hydrogen molecule alleviates TNFα-induced cell injury in osteoblast. Mol Cell Biochem, 373(1-2):1-9. [17]CejkaC, KosslJ, HolanV, et al., 2020. An immunohistochemical study of the increase in antioxidant capacity of corneal epithelial cells by molecular hydrogen, leading to the suppression of alkali-induced oxidative stress. Oxid Med Cell Longev, 2020:7435260. [18]ChenHG, XieKL, HanHZ, et al., 2015. Molecular hydrogen protects mice against polymicrobial sepsis by ameliorating endothelial dysfunction via an Nrf2/HO-1 signaling pathway. Int Immunopharmacol, 28(1):643-654. [19]ChenHG, MaoX, MengXY, et al., 2019. Hydrogen alleviates mitochondrial dysfunction and organ damage via autophagy-mediated NLRP3 inflammasome inactivation in sepsis. Int J Mol Med, 44(4):1309-1324. [20]ChenHG, HanHZ, LiY, et al., 2020. Hydrogen alleviated organ injury and dysfunction in sepsis: the role of cross-talk between autophagy and endoplasmic reticulum stress: experimental research. Int Immunopharmacol, 78:106049. [21]ChenJB, KongXF, LvYY, et al., 2019. “Real world survey” of hydrogen-controlled cancer: a follow-up report of 82 advanced cancer patients. Med Gas Res, 9(3):115-121. [22]ChenK, WangN, DiaoY, et al., 2017. Hydrogen-rich saline attenuates brain injury induced by cardiopulmonary bypass and inhibits microvascular endothelial cell apoptosis via the PI3K/Akt/GSK3β signaling pathway in rats. Cell Phys Biochem, 43(4):1634-1647. [23]ChenMH, ZhangJ, ChenY, et al., 2018. Hydrogen protects lung from hypoxia/re-oxygenation injury by reducing hydroxyl radical production and inhibiting inflammatory responses. Sci Rep, 8:8004. [24]ChenX, CuiJ, ZhaiX, et al., 2018. Inhalation of hydrogen of different concentrations ameliorates spinal cord injury in mice by protecting spinal cord neurons from apoptosis, oxidative injury and mitochondrial structure damages. Cell Phys Biochem, 47:176-190. [25]ChenYL, JiangJY, MiaoHB, et al., 2013. Hydrogen-rich saline attenuates vascular smooth muscle cell proliferation and neointimal hyperplasia by inhibiting reactive oxygen species production and inactivating the Ras-ERK1/2-MEK1/2 and Akt pathways. Int J Mol Med, 31(3):597-606. [26]ChienJY, HsuehPR, ChengWC, et al., 2006. Temporal changes in cytokine/chemokine profiles and pulmonary involvement in severe acute respiratory syndrome. Respirology, 11(6):715-722. [27]China National Health Commission, 2020. Chinese Clinical Guidance for COVID-19 pneumonia diagnosis and treatment (7th Edition). http://kjfy.meetingchina.org/msite/news/show/cn/3337.html?from=singlemessage&isappinstalled=0 [Accessed on May 10, 2021]. [28]ComhairSAA, BhathenaPR, DweikRA, et al., 2000. Rapid loss of superoxide dismutase activity during antigen-induced asthmatic response. Lancet, 355(9204):624. [29]ComhairSAA, BhathenaPR, FarverC, et al., 2001. Extracellular glutathione peroxidase induction in asthmatic lungs: evidence for redox regulation of expression in human airway epithelial cells. FASEB J, 15(1):70-78. [30]CottinV, 2013. Interstitial lung disease. Eur Respir Rev, 22(127):26-32. [31]CuiYM, ZhangH, JiMH, et al., 2014. Hydrogen-rich saline attenuates neuronal ischemia-reperfusion injury by protecting mitochondrial function in rats. J Surg Res, 192(2):564-572. [32]Den HengstWA, GielisJF, LinJY, et al., 2010. Lung ischemia-reperfusion injury: a molecular and clinical view on a complex pathophysiological process. Am J Phys Heart Circ Phys, 299(5):H1283-H1299. [33]DeVriesR, KriebelD, SamaS, 2016. Low level air pollution and exacerbation of existing copd: a case crossover analysis. Environ Health, 15:98. [34]DiaoMY, ZhangS, WuLF, et al., 2016. Hydrogen gas inhalation attenuates seawater instillation-induced acute lung injury via the Nrf2 pathway in rabbits. Inflammation, 39(6):2029-2039. [35]ElmoreS, 2007. Apoptosis: a review of programmed cell death. Toxicol Pathol, 35(4):495-516. [36]FangY, FuXJ, GuC, et al., 2011. Hydrogen-rich saline protects against acute lung injury induced by extensive burn in rat model. J Burn Care Res, 32(3):e82-e91. [37]FehrenbachH, WagnerC, WegmannM, 2017. Airway remodeling in asthma: what really matters. Cell Tissue Res, 367(3):551-569. [38]FengS, DuanEH, ShiXJ, et al., 2019. Hydrogen ameliorates lung injury in a rat model of subacute exposure to concentrated ambient PM2.5 via Aryl hydrocarbon receptor. Int Immunopharmacol, 77:105939. [39]FerrariR, CeconiC, CurelloS, et al., 1991. The occurrence of oxidative stress during reperfusion in experimental animals and men. Cardiovasc Drugs Ther, 5(S2):277-287. [40]FitzgeraldKA, KaganJC, 2020. Toll-like receptors and the control of immunity. Cell, 180(6):1044-1066. [41]FritschJ, LenzO, FriedrichB, 2013. Structure, function and biosynthesis of O2-tolerant hydrogenases. Nat Rev Microbiol, 11(2):106-114. [42]FuZL, ZhangZ, WuXY, et al., 2020. Hydrogen-rich saline inhibits lipopolysaccharide-induced acute lung injury and endothelial dysfunction by regulating autophagy through mTOR/TFEB signaling pathway. Biomed Res Int, 2020:9121894. [43]GeYH, WuFX, SunXJ, et al., 2014. Intrathecal infusion of hydrogen-rich normal saline attenuates neuropathic pain via inhibition of activation of spinal astrocytes and microglia in rats. PLoS ONE, 9(5):e97436. [44]GenestraM, 2007. Oxyl radicals, redox-sensitive signalling cascades and antioxidants. Cell Signal, 19(9):1807-1819. [45]GharibB, HannaS, AbdallahiOM, et al., 2001. Anti-inflammatory properties of molecular hydrogen: investigation on parasite-induced liver inflammation. C R Acad Sci III, 324(8):719-724. [46]GiannottaM, TraniM, DejanaE, 2013. VE-cadherin and endothelial adherens junctions: active guardians of vascular integrity. Dev Cell, 26(5):441-454. [47]GoldenTR, MelovS, 2007. Gene expression changes associated with aging in C. elegans. In: WormBook (Ed.), The C. elegans Research Community. WormBook, p.1-12. [48]GossCH, BrowerRG, HudsonLD, et al., 2003. Incidence of acute lung injury in the United States. Crit Care Med, 31(6):1607-1611. [49]GottliebRA, 2011. Cell death pathways in acute ischemia/reperfusion injury. J Cardiovasc Pharmacol Ther, 16(3-4):233-238. [50]GuerrinaN, TraboulsiH, EidelmanDH, et al., 2018. The Aryl Hydrocarbon Receptor and the maintenance of lung health. Int J Mol Sci, 19(12):3882. [51]GuoHT, CallawayJB, TingJPY, 2015. Inflammasomes: mechanism of action, role in disease, and therapeutics. Nat Med, 21(7):677-687. [52]GuoSX, FangQ, YouCG, et al., 2015. Effects of hydrogen-rich saline on early acute kidney injury in severely burned rats by suppressing oxidative stress induced apoptosis and inflammation. J Trans Med, 13:183. [53]GuzikTJ, TouyzRM, 2017. Oxidative stress, inflammation, and vascular aging in hypertension. Hypertension, 70(4):660-667. [54]HaahtelaT, 1997. Airway remodelling takes place in asthma—what are the clinical implications? Clin Exp Allergy, 27(4):351-353. [55]HanAL, ParkSH, ParkMS, 2017. Hydrogen treatment protects against cell death and senescence induced by oxidative damage. J Microbiol Biotechnol, 27(2):365-371. [56]HeB, ZhangYF, KangB, et al., 2013. Protection of oral hydrogen water as an antioxidant on pulmonary hypertension. Mol Biol Rep, 40(9):5513-5521. [57]HeC, MurthyS, McCormickML, et al., 2011. Mitochondrial Cu, Zn-superoxide dismutase mediates pulmonary fibrosis by augmenting H2O2 generation. J Biol Chem, 286(17):15597-15607. [58]HewlettJC, KropskiJA, BlackwellTS, 2018. Idiopathic pulmonary fibrosis: epithelial-mesenchymal interactions and emerging therapeutic targets. Matrix Biol, 71-72:112-127. [59]HiranoSI, IchikawaY, KurokawaR, et al., 2020. A “philosophical molecule,” hydrogen may overcome senescence and intractable diseases. Med Gas Res, 10(1):47-49. [60]HongYC, SunL, SunRQ, et al., 2016. Combination therapy of molecular hydrogen and hyperoxia improves survival rate and organ damage in a zymosan-induced generalized inflammation model. Exp Ther Med, 11(6):2590-2596. [61]HongYC, ChenHG, YuYH, et al., 2017. Effect of combination therapy with propofol and hydrogen-rich saline on organ damage and cytokines in a murine model of sepsis. Chin Crit Care Med, 29(4):316-320 (in Chinese). [62]HosokawaS, HaraguchiG, SasakiA, et al., 2013. Pathophysiological roles of nuclear factor kappaB (NF-κB) in pulmonary arterial hypertension: effects of synthetic selective NF-κB inhibitor IMD-0354. Cardiovasc Res, 99(1):35-43. [63]HuQG, ZhouYX, WuSJ, et al., 2020. Molecular hydrogen: a potential radioprotective agent. Biomed Pharmacother, 130:110589. [64]HuangCS, KawamuraT, LeeS, et al., 2010. Hydrogen inhalation ameliorates ventilator-induced lung injury. Crit Care, 14:R234. [65]HuangCS, KawamuraT, PengXM, et al., 2011. Hydrogen inhalation reduced epithelial apoptosis in ventilator-induced lung injury via a mechanism involving nuclear factor-kappa B activation. Biochem Biophys Res Commun, 408(2):253-258. [66]HuangKJ, SuIJ, TheronM, et al., 2005. An interferon-γ-related cytokine storm in SARS patients. J Med Virol, 75(2):185-194. [67]HuangPK, WeiSS, HuangWH, et al., 2019. Hydrogen gas inhalation enhances alveolar macrophage phagocytosis in an ovalbumin-induced asthma model. Int Immunopharmacol, 74:105646. [68]HuoTT, ZengY, LiuXN, et al., 2014. Hydrogen-rich saline improves survival and neurological outcome after cardiac arrest and cardiopulmonary resuscitation in rats. Anesth Analg, 119(2):368-380. [69]IketaniM, OhsawaI, 2017. Molecular hydrogen as a neuroprotective agent. Curr Neuropharmacol, 15(2):324-331. [70]JiangY, LiuG, ZhangL, et al., 2018. Therapeutic efficacy of hydrogen-rich saline alone and in combination with PI3K inhibitor in non-small cell lung cancer. Mol Med Rep, 18(2):2182-2190. [71]JiaoY, YuY, LiB, et al., 2020. Protective effects of hydrogen-rich saline against experimental diabetic peripheral neuropathy via activation of the mitochondrial ATP-sensitive potassium channel channels in rats. Mol Med Rep, 21(1):282-290. [72]KanXC, ChenYS, HuangBX, et al., 2021. Effect of Palrnatine on lipopolysaccharide-induced acute lung injury by inhibiting activation of the Akt/NF-κB pathway. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 22(11):929-940. [73]KawamuraM, ImamuraR, KobayashiY, et al., 2020. Oral administration of Si-based agent attenuates oxidative stress and ischemia-reperfusion injury in a rat model: a novel hydrogen administration method. Front Med, 7:95. [74]KawamuraT, HuangCS, TochigiN, et al., 2010. Inhaled hydrogen gas therapy for prevention of lung transplant-induced ischemia/reperfusion injury in rats. Transplantation, 90(12):1344-1351. [75]KawamuraT, HuangCS, PengXM, et al., 2011. The effect of donor treatment with hydrogen on lung allograft function in rats. Surgery, 150(2):240-249. [76]KawamuraT, WakabayashiN, ShigemuraN, et al., 2013. Hydrogen gas reduces hyperoxic lung injury via the Nrf2 pathway in vivo. Am J Phys Lung Cell Mol Phys, 304(10):L646-L656. [77]KawamuraT, HigashidaK, MuraokaI, 2020. Application of molecular hydrogen as a novel antioxidant in sports science. Oxid Med Cell Longev, 2020:2328768. [78]KimYW, ByzovaTV, 2014. Oxidative stress in angiogenesis and vascular disease. Blood, 123(5):625-631. [79]KouZ, ZhaoPH, WangZH, et al., 2019. Acid-responsive H2-releasing Fe nanoparticles for safe and effective cancer therapy. J Mater Chem B, 7(17):2759-2765. [80]KoyamaY, TauraK, HatanoE, et al., 2014. Effects of oral intake of hydrogen water on liver fibrogenesis in mice. Hepatol Res, 44(6):663-677. [81]KuraB, BagchiAK, SingalPK, et al., 2019. Molecular hydrogen: potential in mitigating oxidative-stress-induced radiation injury. Can J Phys Pharmacol, 97(4):287-292. [82]LamkanfiM, DixitVM, 2014. Mechanisms and functions of inflammasomes. Cell, 157(5):1013-1022. [83]LeeWL, SlutskyAS, 2010. Sepsis and endothelial permeability. N Engl J Med, 363(7):689-691. [84]LiH, ZhouRH, LiuJ, et al., 2012. Hydrogen-rich saline attenuates lung ischemia-reperfusion injury in rabbits. J Surg Res, 174(1):e11-e16. [85]LiH, YinYR, LiuJ, et al., 2021. Hydrogen-rich water attenuates the radiotoxicity induced by tritium exposure in vitro and in vivo. J Radiat Res, 62(1):34-45. [86]LiJ, HongZJ, LiuH, et al., 2016. Hydrogen-rich saline promotes the recovery of renal function after ischemia/reperfusion injury in rats via anti-apoptosis and anti-inflammation. Front Pharmacol, 7:106. [87]LiRC, LiuYL, XieJ, et al., 2019. Sirt3 mediates the protective effect of hydrogen in inhibiting ROS-induced retinal senescence. Free Radic Biol Med, 135:116-124. [88]LiT, DengSH, LeiW, et al., 2020. Hydrogen water alleviates paraquat-induced lung fibroblast injury in vitro by enhancing Nrf2 expression. J Southern Med Univ, 40(2):233-239 (in Chinese). [89]LiY, XieKL, ChenHG, et al., 2015. Hydrogen gas inhibits high-mobility group box 1 release in septic mice by upregulation of heme oxygenase 1. J Surg Res, 196(1):136-148. [90]LiY, ChenHG, ShuRC, et al., 2020. Hydrogen treatment prevents lipopolysaccharide-induced pulmonary endothelial cell dysfunction through RhoA inhibition. Biochem Biophys Res Commun, 522(2):499-505. [91]LiangCX, LiuXW, LiuL, et al., 2012. Effect of hydrogen inhalation on p38 MAPK activation in rats with lipopolysaccharide-induced acute lung injury. J Southern Med Univ, 32(8):1211-1213, 1217. [92]LiuHY, LiangXJ, WangDD, et al., 2015. Combination therapy with nitric oxide and molecular hydrogen in a murine model of acute lung injury. Shock, 43(5):504-511. [93]LiuLD, WuXY, TaoBD, et al., 2016. Protective effect and mechanism of hydrogen treatment on lung epithelial barrier dysfunction in rats with sepsis. Genet Mol Res, 15(1):gmr.15016050. [94]LiuMY, XieF, ZhangY, et al., 2019. Molecular hydrogen suppresses glioblastoma growth via inducing the glioma stem-like cell differentiation. Stem Cell Res Ther, 10:145. [95]LiuRF, FangXH, MengC, et al., 2015. Lung inflation with hydrogen during the cold ischemia phase decreases lung graft injury in rats. Exp Biol Med, 240(9):1214-1222. [96]LiuSL, LiuK, SunQ, et al., 2011. Hydrogen therapy may be a novel and effective treatment for COPD. Front Pharmacol, 2:19. [97]LiuW, ShanLP, DongXS, et al., 2013. Combined early fluid resuscitation and hydrogen inhalation attenuates lung and intestine injury. World J Gastroenterol, 19(4):492-502. [98]LiuX, MaC, WangX, et al., 2017. Hydrogen coadministration slows the development of COPD-like lung disease in a cigarette smoke-induced rat model. Int J Chron Obstruct Pulmon Dis, 12:1309-1324. [99]LiuYM, ZhangJ, 2017. Saturated hydrogen saline ameliorates lipopolysaccharide-induced acute lung injury by reducing excessive autophagy (Review). Exp Ther Med, 13(6):2609-2615. [100]LiuYQ, LiuYF, MaXM, et al., 2015. Hydrogen-rich saline attenuates skin ischemia/reperfusion induced apoptosis via regulating Bax/Bcl-2 ratio and ASK-1/JNK pathway. J Plast Reconstr Aesthet Surg, 68(7):e147-e156. [101]LuWJ, LiDF, HuJY, et al., 2018. Hydrogen gas inhalation protects against cigarette smoke-induced COPD development in mice. J Thorac Dis, 10(6):3232-3243. [102]MaiuriMC, ZalckvarE, KimchiA, et al., 2007. Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol, 8(9):741-752. [103]MaoYF, ZhengXF, CaiJM, et al., 2009. Hydrogen-rich saline reduces lung injury induced by intestinal ischemia/reperfusion in rats. Biochem Biophys Res Commun, 381(4):602-605. [104]Marcos-RamiroB, García-WeberD, MillánJ, 2014. TNF-induced endothelial barrier disruption: beyond actin and Rho. Thromb Haemost, 112(6):1088-1102. [105]MaybauerMO, MaybauerDM, HerndonDN, 2006. Incidence and outcomes of acute lung injury. N Engl J Med, 354(4):416-417. [106]MoXY, LiXM, SheCS, et al., 2019. Hydrogen-rich saline protects rat from oxygen glucose deprivation and reperusion-induced apoptosis through VDAC1 via Bcl-2. Brain Res, 1706:110-115. [107]MurthyS, Adamcakova-DoddA, PerrySS, et al., 2009. Modulation of reactive oxygen species by Rac1 or catalase prevents asbestos-induced pulmonary fibrosis. Am J Phys Lung Cell Mol Phys, 297(5):L846-L855. [108]NewgardCB, SharplessNE, 2013. Coming of age: molecular drivers of aging and therapeutic opportunities. J Clin Invest, 123(3):946-950. [109]NieCQ, DingX, A R, et al., 2021. Hydrogen gas inhalation alleviates myocardial ischemia-reperfusion injury by the inhibition of oxidative stress and NLRP3-mediated pyroptosis in rats. Life Sci, 272:119248. [110]NingYY, ShangY, HuangHD, et al., 2013. Attenuation of cigarette smoke-induced airway mucus production by hydrogen-rich saline in rats. PLoS ONE, 8(12):e83429. [111]OhsawaI, IshikawaM, TakahashiK, et al., 2007. Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med, 13(6):688-694. [112]OhtaS, 2012. Molecular hydrogen is a novel antioxidant to efficiently reduce oxidative stress with potential for the improvement of mitochondrial diseases. Biochim Biophys Acta Gener Subj, 1820(5):586-594. [113]OhtaS, 2014. Molecular hydrogen as a preventive and therapeutic medical gas: initiation, development and potential of hydrogen medicine. Pharmacol Ther, 144(1):1-11. [114]OhtaS, 2015. Molecular hydrogen as a novel antioxidant: overview of the advantages of hydrogen for medical applications. Methods Enzymol, 555:289-317. [115]Osborn-HeafordHL, MurthyS, GuLL, et al., 2015. Targeting the isoprenoid pathway to abrogate progression of pulmonary fibrosis. Free Radic Biol Med, 86:47-56. [116]ParkI, KimM, ChoeK, et al., 2019. Neutrophils disturb pulmonary microcirculation in sepsis-induced acute lung injury. Eur Respir J, 53(3):1800786. [117]PaulinR, CourboulinA, MelocheJ, et al., 2011. Signal transducers and activators of transcription-3/Pim1 axis plays a critical role in the pathogenesis of human pulmonary arterial hypertension. Circulation, 123(11):1205-1215. [118]Perez-VizcainoF, CogolludoA, MorenoL, 2010. Reactive oxygen species signaling in pulmonary vascular smooth muscle. Respir Phys Neurobiol, 174(3):212-220. [119]PinamontiS, MuzzoliM, ChiccaMC, et al., 1996. Xanthine oxidase activity in bronchoalveolar lavage fluid from patients with chronic obstructive pulmonary disease. Free Radic Biol Med, 21(2):147-155. [120]PistrittoG, TrisciuoglioD, CeciC, et al., 2016. Apoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategies. Aging, 8(4):603-619. [121]PorteousMK, DiamondJM, ChristieJD, 2015. Primary graft dysfunction: lessons learned about the first 72 h after lung transplantation. Curr Opin Organ Trans, 20(5):506-514. [122]PriceLC, WortSJ, PerrosF, et al., 2012. Inflammation in pulmonary arterial hypertension. Chest, 141(1):210-221. [123]QianLR, CaoF, CuiJG, et al., 2010. Radioprotective effect of hydrogen in cultured cells and mice. Free Radic Res, 44(3):275-282. [124]QinC, BianYX, FengTT, et al., 2017. Effects of hydrogen on the lung damage of mice at early stage of severe burn. Chin J Burns, 33(11):682-687 (in Chinese). [125]QiuXC, DongKS, GuanJZ, et al., 2020. Hydrogen attenuates radiation-induced intestinal damage by reducing oxidative stress and inflammatory response. Int Immunopharmacol, 84:106517. [126]ReuterS, GuptaSC, ChaturvediMM, et al., 2010. Oxidative stress, inflammation, and cancer: how are they linked? Free Radic Biol Med, 49(11):1603-1616. [127]RicciardoloFLM, di StefanoA, SabatiniF, et al., 2006. Reactive nitrogen species in the respiratory tract. Eur J Pharmacol, 533(1-3):240-252. [128]SaitoM, Chen-YoshikawaTF, TakahashiM, et al., 2020. Protective effects of a hydrogen-rich solution during cold ischemia in rat lung transplantation. J Thorac Cardiovasc Surg, 159(5):2110-2118. [129]SakaiT, KurokawaR, HiranoSI, et al., 2019. Hydrogen indirectly suppresses increases in hydrogen peroxide in cytoplasmic hydroxyl radical-induced cells and suppresses cellular senescence. Int J Mol Sci, 20(2):456. [130]SchnittlerH, 2016. Contraction of endothelial cells: 40 years of research, but the debate still lives. Histochem Cell Biol, 146(6):651-656. [131]ShaliniS, DorstynL, DawarS, et al., 2015. Old, new and emerging functions of caspases. Cell Death Differ, 22(4):526-539. [132]ShaoAW, WuHJ, HongY, et al., 2016. Hydrogen-rich saline attenuated subarachnoid hemorrhage-induced early brain injury in rats by suppressing inflammatory response: possible involvement of NF-κB pathway and NLRP3 inflammasome. Mol Neurobiol, 53(5):3462-3476. [133]ShiJJ, GaoWQ, ShaoF, 2017. Pyroptosis: gasdermin-mediated programmed necrotic cell death. Trends Biochem Sci, 42(4):245-254. [134]ShiQ, ChenC, DengWH, et al., 2016. Hydrogen-rich saline attenuates acute hepatic injury in acute necrotizing pancreatitis by inhibiting inflammation and apoptosis, involving JNK and p38 mitogen-activated protein kinase-dependent reactive oxygen species. Pancreas, 45(10):1424-1431. [135]ShinboT, KokuboK, SatoY, et al., 2013. Breathing nitric oxide plus hydrogen gas reduces ischemia-reperfusion injury and nitrotyrosine production in murine heart. Am J Phys Heart Circ Phys, 305(4):H542-H550. [136]SimonneauG, MontaniD, CelermajerDS, et al., 2019. Haemodynamic definitions and updated clinical classification of pulmonary hypertension. Eur Respir J, 53(1):1801913. [137]SingerM, DeutschmanCS, SeymourCW, et al., 2016. The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA, 315(8):801-810. [138]SinghR, LetaiA, SarosiekK, 2019. Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins. Nat Rev Mol Cell Biol, 20(3):175-193. [139]SongYL, MaTH, MatthayMA, et al., 2000. Role of aquaporin-4 in airspace-to-capillary water permeability in intact mouse lung measured by a novel gravimetric method. J Gen Phys, 115(1):17-27. [140]SongYL, JayaramanS, YangBX, et al., 2001. Role of aquaporin water channels in airway fluid transport, humidification, and surface liquid hydration. J Gen Phys, 117(6):573-582. [141]StumpCS, ClarkSE, SowersJR, 2005. Oxidative stress in insulin-resistant conditions: cardiovascular implications. Treat Endocrinol, 4(6):343-351. [142]SunQ, KawamuraT, MasutaniK, et al., 2012. Oral intake of hydrogen-rich water inhibits intimal hyperplasia in arterialized vein grafts in rats. Cardiovasc Res, 94(1):144-153. [143]SunQ, HanWJ, HuHJ, et al., 2017. Hydrogen alleviates hyperoxic acute lung injury related endoplasmic reticulum stress in rats through upregulation of SIRT1. Free Radic Res, 51(6):622-632. [144]SuzukiY, SatoT, SugimotoM, et al., 2017. Hydrogen-rich pure water prevents cigarette smoke-induced pulmonary emphysema in SMP30 knockout mice. Biochem Biophys Res Commun, 492(1):74-81. [145]TangDL, KangR, CoyneCB, et al., 2012. PAMPs and DAMPs: signal 0s that spur autophagy and immunity. Immunol Rev, 249(1):158-175. [146]TangYJ, LiuJJ, ZhangDY, et al., 2020. Cytokine storm in COVID-19: the current evidence and treatment strategies. Front Immunol, 11:1708. [147]TaoBD, LiuLD, WangN, et al., 2016. Effects of hydrogen-rich saline on aquaporin 1, 5 in septic rat lungs. J Surg Res, 202(2):291-298. [148]TerasakiY, TerasakiM, KanazawaS, et al., 2019a. Effect of H2 treatment in a mouse model of rheumatoid arthritis-associated interstitial lung disease. J Cell Mol Med, 23(10):7043-7053. [149]TerasakiY, SuzukiT, TonakiK, et al., 2019b. Molecular hydrogen attenuates gefitinib-induced exacerbation of naphthalene-evoked acute lung injury through a reduction in oxidative stress and inflammation. Lab Invest, 99(6):793-806. [150]ThieryJP, AcloqueH, HuangRYJ, et al., 2009. Epithelial-mesenchymal transitions in development and disease. Cell, 139(5):871-890. [151]VaziriND, Rodríguez-IturbeB, 2006. Mechanisms of disease: oxidative stress and inflammation in the pathogenesis of hypertension. Nat Clin Pract Nephrol, 2(10):582-593. [152]WangC, LiJ, LiuQ, et al., 2011. Hydrogen-rich saline reduces oxidative stress and inflammation by inhibit of JNK and NF-κB activation in a rat model of amyloid-beta-induced Alzheimer's disease. Neurosci Lett, 491(2):127-132. [153]WangDC, WangLF, ZhangY, et al., 2018. Hydrogen gas inhibits lung cancer progression through targeting SMC3. Biomed Pharmacother, 104:788-797. [154]WangST, BaoC, HeY, et al., 2020. Hydrogen gas (XEN) inhalation ameliorates airway inflammation in asthma and COPD patients. QJM Int J Med, 113(12):870-875. [155]WangY, JingL, ZhaoXM, et al., 2011. Protective effects of hydrogen-rich saline on monocrotaline-induced pulmonary hypertension in a rat model. Respir Res, 12:26. [156]WangY, ZhangJH, BoJS, et al., 2019. Hydrogen-rich saline ameliorated LPS-induced acute lung injury via autophagy inhibition through the ROS/AMPK/mTOR pathway in mice. Exp Biol Med, 244(9):721-727. [157]WangYF, WangL, HuTP, et al., 2020. Hydrogen improves cell viability partly through inhibition of autophagy and activation of PI3K/Akt/GSK3β signal pathway in a microvascular endothelial cell model of traumatic brain injury. Neurol Res, 42(6):487-496. [158]WestphalD, KluckRM, DewsonG, 2014. Building blocks of the apoptotic pore: how Bax and Bak are activated and oligomerize during apoptosis. Cell Death Differ, 21(2):196-205. [159]WuD, LiangML, DangHX, et al., 2018. Hydrogen protects against hyperoxia-induced apoptosis in type II alveolar epithelial cells via activation of PI3K/Akt/Foxo3a signaling pathway. Biochem Biophys Res Commun, 495(2):1620-1627. [160]WuJQ, KostenTR, ZhangXY, 2013. Free radicals, antioxidant defense systems, and schizophrenia. Prog Neuro-Psychopharmacol Biol Psych, 46:200-206. [161]WuMY, YiangGT, LiaoWT, et al., 2018. Current mechanistic concepts in ischemia and reperfusion injury. Cell Phys Biochem, 46(4):1650-1667. [162]XiaoM, ZhuT, WangT, et al., 2013. Hydrogen-rich saline reduces airway remodeling via inactivation of NF-κB in a murine model of asthma. Eur Rev Med Pharmacol Sci, 17(8):1033-1043. [163]XieKL, YuYH, PeiYP, et al., 2010. Protective effects of hydrogen gas on murine polymicrobial sepsis via reducing oxidative stress and HMGB1 release. Shock, 34(1):90-97. [164]XieKL, YuYH, HuangY, et al., 2012. Molecular hydrogen ameliorates lipopolysaccharide-induced acute lung injury in mice through reducing inflammation and apoptosis. Shock, 37(5):548-555. [165]XieKL, ZhangY, WangYQ, et al., 2020. Hydrogen attenuates sepsis-associated encephalopathy by NRF2 mediated NLRP3 pathway inactivation. Inflamm Res, 69(7):697-710. [166]XuFF, YuSQ, QinML, et al., 2018. Hydrogen-rich saline ameliorates allergic rhinitis by reversing the imbalance of Th1/Th2 and up-regulation of CD4+CD25+Foxp3+regulatory T Cells, interleukin-10, and membrane-bound transforming growth factor-βin guinea pigs. Inflammation, 41(1):81-92. [167]XuZ, ShiL, WangYJ, et al., 2020. Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir Med, 8(4):420-422. [168]YanMY, YuY, MaoX, et al., 2019. Hydrogen gas inhalation attenuates sepsis-induced liver injury in a FUNDC1-dependent manner. Int Immunopharmacol, 71:61-67. [169]YanWM, ZhangL, ChenT, et al., 2017. Effects of hydrogen-rich saline on endotoxin-induced uveitis. Med Gas Res, 7(1):9-18. [170]YangFX, YueRM, LuoXX, et al., 2020. Hydrogen: a potential new adjuvant therapy for COVID-19 patients. Front Pharmacol, 11:543718. [171]YangM, YuY, XieKL, et al., 2019. Effects of hydrogen on lung injury in wild-type and Nrf2 gene knockout mice: relationship with Nrf2/HO-1/HMGB1 pathway. Chin Crit Care Med, 31(7):862-866 (in Chinese). [172]YangT, WangL, SunRQ, et al., 2016. Hydrogen-rich medium ameliorates lipopolysaccharide-induced barrier dysfunction via RhoA-mDia1 signaling in Caco-2 cells. Shock, 45(2):228-237. [173]YangY, LiuPY, BaoW, et al., 2020. Hydrogen inhibits endometrial cancer growth via a ROS/NLRP3/caspase-1/GSDMD-mediated pyroptotic pathway. BMC Cancer, 20:28. [174]YangZF, KlionskyDJ, 2010. Mammalian autophagy: core molecular machinery and signaling regulation. Curr Opin Cell Biol, 22(2):124-131. [175]YaoL, ChenHG, WuQH, et al., 2019. Hydrogen-rich saline alleviates inflammation and apoptosis in myocardial I/R injury via PINK-mediated autophagy. Int J Mol Med, 44(3):1048-1062. [176]YingYG, XuHZ, YaoM, et al., 2017. Protective effect of hydrogen-saturated saline on acute lung injury induced by oleic acid in rats. J Orthop Surg Res, 12:134. [177]YuY, YangYY, YangM, et al., 2019. Hydrogen gas reduces HMGB1 release in lung tissues of septic mice in an Nrf2/HO-1-dependent pathway. Int Immunopharmacol, 69:11-18. [178]YuY, FengJC, LianNQ, et al., 2020. Hydrogen gas alleviates blood-brain barrier impairment and cognitive dysfunction of septic mice in an Nrf2-dependent pathway. Int Immunopharmacol, 85:106585. [179]YueC, JiC, ZhangH, et al., 2017. Protective effects of folic acid on PM2.5-induced cardiac developmental toxicity in zebrafish embryos by targeting AhR and Wnt/β-catenin signal pathways. Environ Toxicol, 32(10):2316-2322. [180]ZhaQB, WeiHX, LiCG, et al., 2016. ATP-induced inflammasome activation and pyroptosis is regulated by AMP-activated protein kinase in macrophages. Front Immunol, 7:597. [181]ZhangGC, LiZ, MengC, et al., 2018. The anti-inflammatory effect of hydrogen on lung transplantation model of pulmonary microvascular endothelial cells during cold storage period. Transplantation, 102(8):1253-1261. [182]ZhangHQ, DaviesKJA, FormanHJ, 2015. Oxidative stress response and Nrf2 signaling in aging. Free Radic Biol Med, 88:314-336. [183]ZhangM, LiZH, GaoDW, et al., 2020. Hydrogen extends Caenorhabditis elegans longevity by reducing reactive oxygen species. PLoS ONE, 15:e0231972. [184]ZhangN, DengCW, ZhangXX, et al., 2018. Inhalation of hydrogen gas attenuates airway inflammation and oxidative stress in allergic asthmatic mice. Asthma Res Pract, 4:3. [185]ZhangWB, HuangC, SunAJ, et al., 2018. Hydrogen alleviates cellular senescence via regulation of ROS/p53/p21 pathway in bone marrow-derived mesenchymal stem cells in vivo. Biomed Pharmacother, 106:1126-1134. [186]ZhangY, LiuYM, ZhangJ, 2015. Saturated hydrogen saline attenuates endotoxin-induced lung dysfunction. J Surg Res, 198(1):41-49. [187]ZhangYQ, LiuYJ, MaoYF, et al., 2015. Resveratrol ameliorates lipopolysaccharide-induced epithelial mesenchymal transition and pulmonary fibrosis through suppression of oxidative stress and transforming growth factor-β1 signaling. Clin Nutr, 34(4):752-760. [188]ZhaoPH, JinZK, ChenQ, et al., 2018. Local generation of hydrogen for enhanced photothermal therapy. Nat Commun, 9:4241. [189]ZouR, WangMH, ChenY, et al., 2019. Hydrogen-rich saline attenuates acute lung injury induced by limb ischemia/reperfusion via down-regulating chemerin and NLRP3 in rats. Shock, 52(1):134-141. Journal of Zhejiang University-SCIENCE, 38 Zheda Road, Hangzhou
310027, China
Tel: +86-571-87952783; E-mail: cjzhang@zju.edu.cn Copyright © 2000 - 2024 Journal of Zhejiang University-SCIENCE |
Open peer comments: Debate/Discuss/Question/Opinion
<1>