CLC number:
On-line Access: 2022-02-17
Received: 2021-09-15
Revision Accepted: 2021-11-18
Crosschecked: 0000-00-00
Cited: 0
Clicked: 2098
Citations: Bibtex RefMan EndNote GB/T7714
Zhaoshi BAI, Yaling PENG, Xinyue YE, Zhixian LIU, Yupeng LI, Lingman MA. Autophagy and cancer treatment: four functional forms of autophagy and their therapeutic applications[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B2100804 @article{title="Autophagy and cancer treatment: four functional forms of autophagy and their therapeutic applications", %0 Journal Article TY - JOUR
自噬与癌症的治疗:自噬的四种功能形式及其在癌症治疗中的应用关键词组: Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article
Reference[1]AkalayI, JanjiB, HasmimM, et al., 2013. EMT impairs breast carcinoma cell susceptibility to CTL-mediated lysis through autophagy induction. Autophagy, 9(7):1104-1106. [2]AryaBD, MittalS, JoshiP, et al., 2018. Graphene oxide-chloroquine nanoconjugate induce necroptotic death in A549 cancer cells through autophagy modulation. Nanomedicine, 13(18):2261-2282. [3]BaiZS, GaoMQ, ZhangHJ, et al., 2017. BZML, a novel colchicine binding site inhibitor, overcomes multidrug resistance in A549/Taxol cells by inhibiting P-gp function and inducing mitotic catastrophe. Cancer Lett, 402:81-92. [4]BaiZS, GaoMQ, XuXB, et al., 2018. Overcoming resistance to mitochondrial apoptosis by BZML-induced mitotic catastrophe is enhanced by inhibition of autophagy in A549/Taxol cells. Cell Prolif, 51(4):e12450. [5]BaiZS, LiuXL, GuanQ, et al., 2020. 5-(3,4,5-trimethoxybenzoyl)-4-methyl-2-(p-tolyl) imidazol (BZML) targets tubulin and DNA to induce anticancer activity and overcome multidrug resistance in colorectal cancer cells. Chem Biol Interact, 315:108886. [6]Ben-AmarA, MlikiA, 2021. Timely gene detection assay and reliable screening of genetically engineered plants using an improved direct PCR-based technology. Transgenic Res, 30(3):263-274. [7]BialikS, DasariSK, KimchiA, 2018. Autophagy-dependent cell death—where, how and why a cell eats itself to death. J Cell Sci, 131(18):jcs215152. [8]CallJA, NichenkoAS, 2020. Autophagy: an essential but limited cellular process for timely skeletal muscle recovery from injury. Autophagy, 16(7):1344-1347. [9]JMNLCardozo, SchmidtMK, van’t VeerLJ, et al., 2021. Combining method of detection and 70-gene signature for enhanced prognostication of breast cancer. Breast Cancer Res Treat, 189(2):399-410. [10]Chaeichi-TehraniN, FernsGA, HassanianSM, et al., 2021. The therapeutic potential of targeting autophagy in the treatment of cancer. Curr Cancer Drug Targets, 21(9):725-736. [11]ChangCH, BijianK, WernicD, et al., 2019. A novel orally available seleno-purine molecule suppresses triple-negative breast cancer cell proliferation and progression to meta [12]stasis by inducing cytostatic autophagy. Autophagy, 15(8):1376-1390. [13]ChangCM, ShiXS, JensenLE, et al., 2021. Reconstitution of cargo-induced LC3 lipidation in mammalian selective autophagy. Sci Adv, 7(17):eabg4922. [14]ChenGQ, BenthaniFA, WuJ, et al., 2020. Artemisinin compounds sensitize cancer cells to ferroptosis by regulating iron homeostasis. Cell Death Differ, 27(1):242-254. [15]ChenJH, ZhangLM, ZhouH, et al., 2018. Inhibition of autophagy promotes cisplatin-induced apoptotic cell death through Atg5 and Beclin 1 in A549 human lung cancer cells. Mol Med Rep, 17(5):6859-6865. [16]DixonSJ, LembergKM, LamprechtMR, et al., 2012. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell, 149(5):1060-1072. [17]DouQH, ChenHN, WangK, et al., 2016. Ivermectin induces cytostatic autophagy by blocking the PAK1/Akt axis in breast cancer. Cancer Res, 76(15):4457-4469. [18]EndoS, HoshiM, MatsunagaT, et al., 2018. Autophagy inhibition enhances anticancer efficacy of artepillin C, a cinnamic acid derivative in Brazilian green propolis. Biochem Biophys Res Commun, 497(1):437-443. [19]Feliz-MosqueaYR, ChristensenAA, WilsonAS, et al., 2018. Combination of anthracyclines and anti-CD47 therapy inhibit invasive breast cancer growth while preventing cardiac toxicity by regulation of autophagy. Breast Cancer Res Treat, 172(1):69-82. [20]GalluzziL, GreenDR, 2019. Autophagy-independent functions of the autophagy machinery. Cell, 177(7):1682-1699. [21]GalluzziL, VitaleI, AaronsonSA, et al., 2018. Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. Cell Death Differ, 25(3):486-541. [22]GaoMH, MonianP, PanQH, et al., 2016. Ferroptosis is an autophagic cell death process. Cell Res, 26(9):1021-1032. [23]GengSC, LiXL, FangWH, 2020. Porcine circovirus 3 capsid protein induces autophagy in HEK293T cells by inhibiting phosphorylation of the mammalian target of rapamycin. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 21(7):560-570. [24]GewirtzDA, 2014. The four faces of autophagy: implications for cancer therapy. Cancer Res, 74(3):647-651. [25]GiatromanolakiA, KoukourakisMI, GeorgiouI, et al., 2018. LC3A, LC3B and Beclin-1 expression in gastric cancer. Anticancer Res, 38(12):6827-6833. [26]HaasNB, ApplemanLJ, SteinM, et al., 2019. Autophagy inhibition to augment mTOR inhibition: a phase I/II trial of everolimus and hydroxychloroquine in patients with previously treated renal cell carcinoma. Clin Cancer Res, 25(7):2080-2087. [27]HansenAR, TannockIF, TempletonA, et al., 2019. Pantoprazole affecting docetaxel resistance pathways via autophagy (PANDORA): phase II trial of high dose pantoprazole (autophagy inhibitor) with docetaxel in metastatic castration-resistant prostate cancer (mCRPC). Oncologist, 24(9):1188-1194. [28]HouW, XieYC, SongXX, et al., 2016. Autophagy promotes ferroptosis by degradation of ferritin. Autophagy, 12(8):1425-1428. [29]HuYL, JahangiriA, DeLayM, et al., 2012. Tumor cell autophagy as an adaptive response mediating resistance to treatments such as antiangiogenic therapy. Cancer Res, 72(17):4294-4299. [30]HuangYH, YangPM, ChuahQY, et al., 2014. Autophagy promotes radiation-induced senescence but inhibits bystander effects in human breast cancer cells. Autophagy, 10(7):1212-1228. [31]JeongS, KimBG, KimDY, et al., 2019. Cannabidiol overcomes oxaliplatin resistance by enhancing NOS3- and SOD2-induced autophagy in human colorectal cancer cells. Cancers, 11(6):781. [32]KimSY, HwangboH, KimMY, et al., 2021. Coptisine induces autophagic cell death through down-regulation of PI3K/Akt/mTOR signaling pathway and up-regulation of ROS-mediated mitochondrial dysfunction in hepatocellular carcinoma Hep3B cells. Arch Biochem Biophys, 697:108688. [33]KongYL, HuangY, WuJZ, et al., 2018. Expression of autophagy related genes in chronic lymphocytic leukemia is associated with disease course. Leuk Res, 66:8-14. [34]LawBYK, MichelangeliF, QuYQ, et al., 2019. Neferine induces autophagy-dependent cell death in apoptosis-resistant cancers via ryanodine receptor and Ca2+-dependent mechanism. Sci Rep, 9:20034. [35]LevyJMM, TowersCG, ThorburnA, 2017. Targeting autophagy in cancer. Nat Rev Cancer, 17(9):528-542. [36]LiL, WangYB, JiaoL, et al., 2019. Protective autophagy decreases osimertinib cytotoxicity through regulation of stem cell-like properties in lung cancer. Cancer Lett, 452:191-202. [37]LinJF, LinYC, TsaiTF, et al., 2017. Cisplatin induces protective autophagy through activation of BECN1 in human bladder cancer cells. Drug Des Devel Ther, 11:1517-1533. [38]LinSY, HsiehSY, FanYT, et al., 2018. Necroptosis promotes autophagy-dependent upregulation of DAMP and results in immunosurveillance. Autophagy, 14(5):778-795. [39]LinTY, ChanHH, ChenSH, et al., 2020. BIRC5/survivin is a novel ATG12-ATG5 conjugate interactor and an autophagy-induced DNA damage suppressor in human cancer and mouse embryonic fibroblast cells. Autophagy, 16(7):1296-1313. [40]LiuYM, YangSS, WangKL, et al., 2020. Cellular senescence and cancer: focusing on traditional Chinese medicine and natural products. Cell Prolif, 53(10):e12894. [41]LiuYY, WangN, ZhangSK, et al., 2018. Autophagy protects bone marrow mesenchymal stem cells from palmitate-induced apoptosis through the ROS-JNK/p38 MAPK signaling pathways. Mol Med Rep, 18(2):1485-1494. [42]LuZM, RenYD, YangL, et al., 2021. Inhibiting autophagy enhances sulforaphane-induced apoptosis via targeting NRF2 in esophageal squamous cell carcinoma. Acta Pharm Sin B, 11(5):1246-1260. [43]LystadAH, CarlssonSR, SimonsenA, 2019. Toward the function of mammalian ATG12-ATG5-ATG16L1 complex in autophagy and related processes. Autophagy, 15(8):1485-1486. [44]MaRY, YuDD, PengY, et al., 2021. Resveratrol induces AMPK and mTOR signaling inhibition-mediated autophagy and apoptosis in multiple myeloma cells. Acta Biochim Biophys Sin, 53(6):775-783. [45]MaSM, DielschneiderRF, HensonES, et al., 2017. Ferroptosis and autophagy induced cell death occur independently after siramesine and lapatinib treatment in breast cancer cells. PLoS ONE, 12(8):e0182921. [46]MalhotraJ, JabbourS, OrlickM, et al., 2019. Phase Ib/II study of hydroxychloroquine in combination with chemotherapy in patients with metastatic non-small cell lung cancer (NSCLC). Cancer Treat Res Commun, 21:100158. [47]MaskeyD, YousefiS, SchmidI, et al., 2013. ATG5 is induced by DNA-damaging agents and promotes mitotic catastrophe independent of autophagy. Nat Commun, 4:2130. [48]McKayLK, WhiteJP, 2021. The AMPK/p27Kip1 pathway as a novel target to promote autophagy and resilience in aged cells. Cells, 10(6):1430. [49]MiricescuD, BalanDG, TulinA, et al., 2021. PI3K/AKT/mTOR signalling pathway involvement in renal cell carcinoma pathogenesis (Review). Exp Ther Med, 21(5):540. [50]MoHJ, RennaCE, MooreHCF, et al., 2021. Real-world outcomes of everolimus and exemestane for the treatment of metastatic hormone receptor-positive breast cancer in patients previously treated with CDK4/6 inhibitors. Clin Breast Cancer, in press. [51]NajafovA, ChenHB, YuanJJ, 2017. Necroptosis and cancer. Trends Cancer, 3(4):294-301. [52]NamHY, HanMW, ChangHW, et al., 2013. Prolonged autophagy by MTOR inhibitor leads radioresistant cancer cells into senescence. Autophagy, 9(10):1631-1632. [53]PatelNH, XuJW, SalehT, et al., 2020. Influence of nonprotective autophagy and the autophagic switch on sensitivity to cisplatin in non-small cell lung cancer cells. Biochem Pharmacol, 175:113896. [54]ShangJ, ChenWM, LiuS, et al., 2019. CircPAN3 contributes to drug resistance in acute myeloid leukemia through regulation of autophagy. Leuk Res, 85:106198. [55]SharmaK, GoeheRW, DiX, et al., 2014. A novel cytostatic form of autophagy in sensitization of non-small cell lung cancer cells to radiation by vitamin D and the vitamin D analog, EB 1089. Autophagy, 10(12):2346-2361. [56]SorokinaIV, DenisenkoTV, ImrehG, et al., 2017. Involvement of autophagy in the outcome of mitotic catastrophe. Sci Rep, 7:14571. [57]SunBY, LiuYQ, HeDH, et al., 2021. Traditional Chinese medicines and their active ingredients sensitize cancer cells to trail-induced apoptosis. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 22(3):190-203. [58]SungHH, GiMY, ChaJA, et al., 2021. Gender difference in the relationship between lipid accumulation product index and pulse pressure in nondiabetic Korean adults: The Korean National Health and Nutrition Examination Survey 2013‒2014. Clin Exp Hypertens, in press. [59]ThorburnA, 2020. A new mechanism for autophagy regulation of anti-tumor immune responses. Autophagy, 16(12):2282-2284. [60]ToozeSA, DikicI, 2016. Autophagy captures the Nobel Prize. Cell, 167(6):1433-1435. [61]ToriiS, ShintokuR, KubotaC, et al., 2016. An essential role for functional lysosomes in ferroptosis of cancer cells. Biochem J, 473(6):769-777. [62]TowersCG, WodetzkiD, ThorburnA, 2020. Autophagy and cancer: modulation of cell death pathways and cancer cell adaptations. J Cell Biol, 219(1):e201909033. [63]Tyutyunyk-MasseyL, GewirtzDA, 2020. Roles of autophagy in breast cancer treatment: target, bystander or benefactor. Semin Cancer Biol, 66:155-162. [64]ValenzuelaCA, VargasL, MartinezV, et al., 2017. Palbociclib-induced autophagy and senescence in gastric cancer cells. Exp Cell Res, 360(2):390-396. [65]van der VeldenDL, HoesLR, van der WijngaartH, et al., 2019. The drug rediscovery protocol facilitates the expanded use of existing anticancer drugs. Nature, 574(7776):127-131. [66]VidalL, VictoriaI, GabaL, et al., 2021. A first-in-human phase I/Ib dose-escalation clinical trial of the autophagy inducer ABTL0812 in patients with advanced solid tumours. Eur J Cancer, 146:87-94. [67]VujićN, BradićI, GoeritzerM, et al., 2021. ATG7 is dispensable for LC3-PE conjugation in thioglycolate-elicited mouse peritoneal macrophages. Autophagy, 17(11):3402-3407. [68]WangK, GaoW, DouQH, et al., 2016. Ivermectin induces PAK1-mediated cytostatic autophagy in breast cancer. Autophagy, 12(12):2498-2499. [69]WangQW, LiuWX, LiuGP, et al., 2021. AMPK-mTOR-ULK1-mediated autophagy protects carbon tetrachloride-induced acute hepatic failure by inhibiting p21 in rats. J Toxicol Pathol, 34(1):73-82. [70]WangXY, LiHQ, LiW, et al., 2020. The role of Caspase-1/GSDMD-mediated pyroptosis in Taxol-induced cell death and a Taxol-resistant phenotype in nasopharyngeal carcinoma regulated by autophagy. Cell Biol Toxicol, 36(5):437-457. [71]WangYP, GaoWQ, ShiXY, et al., 2017. Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin. Nature, 547(7661):99-103. [72]WenN, LvQ, DuZG, 2020. MicroRNAs involved in drug resistance of breast cancer by regulating autophagy. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 21(9):690-702. [73]WuSH, SunCB, LiYY, et al., 2015. Autophagy-related genes Raptor, Rictor, and Beclin1 expression and relationship with multidrug resistance in colorectal carcinoma. Hum Pathol, 46(11):1752-1759. [74]XiGM, HuXY, WuBL, et al., 2011. Autophagy inhibition promotes paclitaxel-induced apoptosis in cancer cells. Cancer Lett, 307(2):141-148. [75]Xu HD, Qin ZH, 2019. Beclin 1, Bcl-2 and autophagy.In: Qin ZH (Ed.), Autophagy: Biology and Diseases. Advances in Experimental Medicine and Biology, Vol. 1206. Springer, Singapore, p.109-126. [76]XuJ, JiangJK, LiXL, et al., 2020. Comparative transcriptomic analysis of vascular endothelial cells after hypoxia/re-oxygenation induction based on microarray technology. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 21(4):291-304. [77]XuJW, PatelNH, SalehT, et al., 2018. Differential radiation sensitivity in p53 wild-type and p53-deficient tumor cells associated with senescence but not apoptosis or (nonprotective) autophagy. Radiat Res, 190(5):538-557. [78]YamamotoK, VenidaA, YanoJ, et al., 2020. Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I. Nature, 581(7806):100-105. [79]YangM, YangXM, YinDH, et al., 2018. Beclin1 enhances cisplatin-induced apoptosis via Bcl-2-modulated autophagy in laryngeal carcinoma cells Hep-2. Neoplasma, 65(1):42-48. [80]YuP, WangHY, TianM, et al., 2019. Eukaryotic elongation factor-2 kinase regulates the cross-talk between autophagy and pyroptosis in doxorubicin-treated human melanoma cells in vitro. Acta Pharmacol Sin, 40(9):1237-1244. [81]ZehHJ, BaharyN, BooneBA, et al., 2020. A randomized phase II preoperative study of autophagy inhibition with high-dose hydroxychloroquine and gemcitabine/nab-paclitaxel in pancreatic cancer patients. Clin Cancer Res, 26(13):3126-3134. [82]ZhangJC, YinHL, ChenQD, et al., 2021. Basophils as a potential therapeutic target in cancer. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 22(12):971-984. [83]ZhangQ, WangXB, CaoSJ, et al., 2020. Berberine represses human gastric cancer cell growth in vitro and in vivo by inducing cytostatic autophagy via inhibition of MAPK/mTOR/p70S6K and Akt signaling pathways. Biomed Pharmacother, 128:110245. [84]ZhangRJ, ChenJ, MaoLZ, et al., 2020. Nobiletin triggers reactive oxygen species-mediated pyroptosis through regulating autophagy in ovarian cancer cells. J Agric Food Chem, 68(5):1326-1336. [85]ZhangY, HuangWH, ZhengZM, et al., 2021. Cigarette smoke-inactivated SIRT1 promotes autophagy-dependent senescence of alveolar epithelial type 2 cells to induce pulmonary fibrosis. Free Radic Biol Med, 166:116-127. [86]ZhaoMM, WangRS, ZhouYL, et al., 2020. Emerging relationship between RNA helicases and autophagy. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 21(10):767-778. [87]ZhengHC, ZhaoS, XueH, et al., 2020. The roles of Beclin 1 expression in gastric cancer: a marker for carcinogenesis, aggressive behaviors and favorable prognosis, and a target of gene therapy. Front Oncol, 10:613679. [88]ZhouBY, YangCH, YanX, et al., 2021. LETM1 knockdown promotes autophagy and apoptosis through AMP-activated protein kinase phosphorylation-mediated Beclin-1/Bcl-2 complex dissociation in hepatocellular carcinoma. Front Oncol, 10:606790. [89]ZhouXJ, ChenY, WangFF, et al., 2020. Artesunate induces autophagy dependent apoptosis through upregulating ROS and activating AMPK-mTOR-ULK1 axis in human bladder cancer cells. Chem Biol Interact, 331:109273. [90]ZhuangCL, ChenFE, 2020. Small-molecule inhibitors of necroptosis: current status and perspectives. J Med Chem, 63(4):1490-1510. Journal of Zhejiang University-SCIENCE, 38 Zheda Road, Hangzhou
310027, China
Tel: +86-571-87952783; E-mail: cjzhang@zju.edu.cn Copyright © 2000 - 2024 Journal of Zhejiang University-SCIENCE |
Open peer comments: Debate/Discuss/Question/Opinion
<1>