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On-line Access: 2024-08-27

Received: 2023-10-17

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Journal of Zhejiang University SCIENCE B

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3D printing-assisted freeze-casting of processed pyritum-doped β-TCP biomimetic scaffold with angiogenesis and bone regeneration capability


Author(s):  Chenxu WEI, Zongan LI

Affiliation(s):  School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China; more

Corresponding email(s):  cshi@njucm.edu.cnFeng, liweidong0801@njucm.edu.cn

Key Words:  Bone defect; Processed pyritum; 3D-printing freeze-casting; Angiogenesis; Bone regeneration; VEGF-Notch1-BMP-2-OPN coupling


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Chenxu WEI, Zongan LI,, Xiaoyun LIANG,, Yuwei ZHAO, Xingyu ZHU, Haibing HUA, Guobao CHEN, Kunming QIN, Zhipeng CHEN, Changcan SHI, Feng ZHANG, Weidong LI. 3D printing-assisted freeze-casting of processed pyritum-doped β-TCP biomimetic scaffold with angiogenesis and bone regeneration capability[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B2400340

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author="Chenxu WEI, Zongan LI,, Xiaoyun LIANG,, Yuwei ZHAO, Xingyu ZHU, Haibing HUA, Guobao CHEN, Kunming QIN, Zhipeng CHEN, Changcan SHI, Feng ZHANG, Weidong LI",
journal="Journal of Zhejiang University Science B",
year="in press",
publisher="Zhejiang University Press & Springer",
doi="https://doi.org/10.1631/jzus.B2400340"
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%T 3D printing-assisted freeze-casting of processed pyritum-doped β-TCP biomimetic scaffold with angiogenesis and bone regeneration capability
%A Chenxu WEI
%A Zongan LI
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%A Xiaoyun LIANG
%A
%A Yuwei ZHAO
%A Xingyu ZHU
%A Haibing HUA
%A Guobao CHEN
%A Kunming QIN
%A Zhipeng CHEN
%A Changcan SHI
%A Feng ZHANG
%A Weidong LI
%J Journal of Zhejiang University SCIENCE B
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doi="https://doi.org/10.1631/jzus.B2400340"

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A1 -
A1 - Yuwei ZHAO
A1 - Xingyu ZHU
A1 - Haibing HUA
A1 - Guobao CHEN
A1 - Kunming QIN
A1 - Zhipeng CHEN
A1 - Changcan SHI
A1 - Feng ZHANG
A1 - Weidong LI
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Abstract: 
Bone repair remains an important target in tissue engineering, making the development of bioactive scaffolds for effective bone defect repair a critical objective. In this study, β-tricalcium phosphate (β-TCP) scaffolds incorporated with processed pyritum decoction (PPD) were fabricated using 3D printing-assisted freeze-casting. The produced composite scaffolds were evaluated for their mechanical strength, physicochemical properties, biocompatibility, in vitro pro-angiogenic activity, and in vivo efficacy in repairing rabbit femoral defects. They not only demonstrated excellent physicochemical properties, enhanced mechanical strength and good biosafety but also significantly promoted the proliferation, migration and aggregation of pro-angiogenic human umbilical vein endothelial cells. In vivo studies revealed that all scaffold groups facilitated osteogenesis at the bone defect site, with the β-TCP scaffolds loaded with PPD markedly enhancing the expression of Notch1, vascular endothelial growth factor, bone morphogenetic protein-2, and osteopontin. Overall, the scaffolds developed in this study exhibited strong angiogenic and osteogenic capabilities both in vitro and in vivo. The incorporation of PPD notably promoted the angiogenic-osteogenic coupling, thereby accelerating bone repair, which suggests that PPD is a promising material for bone repair and that the PPD/β-TCP scaffolds hold great potential as a bone graft alternative.

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