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Bio-Design and Manufacturing  2020 Vol.3 No.2 P.83-86

http://doi.org/10.1007/s42242-020-00075-7


Development of a rapid test kit for SARS-CoV-2: an example of product design


Author(s):  Zhanfeng Cui, Hong Chang, Hui Wang, Boon Lim, Chia-Chen Hsu, Yejiong Yu, Huidong Jia, Yun Wang, Yida Zeng, Mengmeng Ji, Weizhi Liu, Catriona Inverarity & Wei E. Huang

Affiliation(s):  Oxford Suzhou Centre for Advanced Research (OSCAR), University of Oxford, Suzhou, Jiangsu, People’s Republic of China; more

Corresponding email(s):   zhanfeng.cui@eng.ox.ac.uk

Key Words:  COVID-19, Antigen detection, Rapid test, Product design, SAR-Cov-2, RT-LAMP


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Zhanfeng Cui, Hong Chang, Hui Wang, Boon Lim, Chia-Chen Hsu, Yejiong Yu, Huidong Jia, Yun Wang, Yida Zeng, Mengmeng Ji, Weizhi Liu, Catriona Inverarity & Wei E. Huang . Development of a rapid test kit for SARS-CoV-2: an example of product design[J]. Journal of Zhejiang University Science D, 2020, 3(2): 83-86.

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Abstract: 
We present an example of applying ‘need-driven’ product design principle to the development of a rapid test kit to detect SARS-COV-2 (COVID-19). The tests are intended for use in the field and, longer term, for home use. They detect whether a subject is currently infected with the virus and is infectious. The urgent need for large numbers of tests in field setting imposes constraints such as short test time and lack of access to specialist equipment, laboratories and skilled technicians to perform the test and interpret results. To meet these needs, an antigen test based on RT-LAMP with colorimetric readout was chosen. Direct use of swab sample with no RNA extraction was explored. After extensive experimental study (reported elsewhere), a rapid test kit has been fabricated to satisfy all design criteria.

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