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On-line Access: 2023-01-19
Received: 2022-08-15
Revision Accepted: 2022-12-06
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Organoids revealed: morphological analysis of the profound next generation in-vitro model with artificial intelligence
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Xuan Du, Zaozao Chen, Qiwei Li, Sheng Yang, Lincao Jiang, Yi Yang, Yanhui Li & Zhongze Gu. Organoids revealed: morphological analysis of the profound next generation in-vitro model with artificial intelligence[J]. Journal of Zhejiang University Science D, 2023, 6(3): 319-339.
@article{title="Organoids revealed: morphological analysis of the profound next generation in-vitro model with artificial intelligence",
author="Xuan Du, Zaozao Chen, Qiwei Li, Sheng Yang, Lincao Jiang, Yi Yang, Yanhui Li & Zhongze Gu",
journal="Journal of Zhejiang University Science D",
volume="6",
number="3",
pages="319-339",
year="2023",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-022-00226-y"
}
%0 Journal Article
%T Organoids revealed: morphological analysis of the profound next generation in-vitro model with artificial intelligence
%A Xuan Du
%A Zaozao Chen
%A Qiwei Li
%A Sheng Yang
%A Lincao Jiang
%A Yi Yang
%A Yanhui Li & Zhongze Gu
%J Journal of Zhejiang University SCIENCE D
%V 6
%N 3
%P 319-339
%@ 1869-1951
%D 2023
%I Zhejiang University Press & Springer
%DOI 10.1007/s42242-022-00226-y
TY - JOUR
T1 - Organoids revealed: morphological analysis of the profound next generation in-vitro model with artificial intelligence
A1 - Xuan Du
A1 - Zaozao Chen
A1 - Qiwei Li
A1 - Sheng Yang
A1 - Lincao Jiang
A1 - Yi Yang
A1 - Yanhui Li & Zhongze Gu
J0 - Journal of Zhejiang University Science D
VL - 6
IS - 3
SP - 319
EP - 339
%@ 1869-1951
Y1 - 2023
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1007/s42242-022-00226-y
Abstract: The human gut microbiota is widely considered to be a metabolic organ hidden within our bodies, playing a crucial role in the host’s physiology. Several factors affect its composition, so a wide variety of microbes residing in the gut are present in the world population. Individual excessive imbalances in microbial composition are often associated with human disorders and pathologies, and new investigative strategies to gain insight into these pathologies and define pharmaceutical therapies for their treatment are needed. In vitro models of the human gut microbiota are commonly used to study microbial fermentation patterns, community composition, and host-microbe interactions. Bioreactors and microfluidic devices have been designed to culture microorganisms from the human gut microbiota in a dynamic environment in the presence or absence of eukaryotic cells to interact with. In this review, we will describe the overall elements required to create a functioning, reproducible, and accurate in vitro culture of the human gut microbiota. In addition, we will analyze some of the devices currently used to study fermentation processes and relationships between the human gut microbiota and host eukaryotic cells.
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