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Enhancing Angiogenesis and Osseointegration through a Double Gyroid Ti6Al4V Scaffold with Triply Periodic Minimal Surface
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Hao Liu, Hao Chen, Bin Sun, Danyang Fan, Aobo Zhang, Hanqiang Liu, Hexiang Wei, Wenbo Yang, Yongyue Li, Peng Xia, Qing Han, Jincheng Wang. Enhancing Angiogenesis and Osseointegration through a Double Gyroid Ti6Al4V Scaffold with Triply Periodic Minimal Surface[J]. Journal of Zhejiang University Science D, 2016, -1(-1): .
@article{title="Enhancing Angiogenesis and Osseointegration through a Double Gyroid Ti6Al4V Scaffold with Triply Periodic Minimal Surface",
author="Hao Liu, Hao Chen, Bin Sun, Danyang Fan, Aobo Zhang, Hanqiang Liu, Hexiang Wei, Wenbo Yang, Yongyue Li, Peng Xia, Qing Han, Jincheng Wang",
journal="Journal of Zhejiang University Science D",
volume="-1",
number="-1",
pages="",
year="2016",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-BDMJ-D-24-00114"
}
%0 Journal Article
%T Enhancing Angiogenesis and Osseointegration through a Double Gyroid Ti6Al4V Scaffold with Triply Periodic Minimal Surface
%A Hao Liu
%A Hao Chen
%A Bin Sun
%A Danyang Fan
%A Aobo Zhang
%A Hanqiang Liu
%A Hexiang Wei
%A Wenbo Yang
%A Yongyue Li
%A Peng Xia
%A Qing Han
%A Jincheng Wang
%J Journal of Zhejiang University SCIENCE D
%V -1
%N -1
%P
%@ 1673-1581
%D 2016
%I Zhejiang University Press & Springer
%DOI 10.1007/s42242-BDMJ-D-24-00114
TY - JOUR
T1 - Enhancing Angiogenesis and Osseointegration through a Double Gyroid Ti6Al4V Scaffold with Triply Periodic Minimal Surface
A1 - Hao Liu
A1 - Hao Chen
A1 - Bin Sun
A1 - Danyang Fan
A1 - Aobo Zhang
A1 - Hanqiang Liu
A1 - Hexiang Wei
A1 - Wenbo Yang
A1 - Yongyue Li
A1 - Peng Xia
A1 - Qing Han
A1 - Jincheng Wang
J0 - Journal of Zhejiang University Science D
VL - -1
IS - -1
SP -
EP -
%@ 1673-1581
Y1 - 2016
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1007/s42242-BDMJ-D-24-00114
Abstract: The pore structure of porous scaffolds plays a crucial role in the bone repair process. Currently, the prevalent bone implant structure in clinical practice is the traditional cubic structure. However, the traditional cubic structure exhibits sharp edges and junctions that are not conducive to cell adhesion and growth. In this study, we devised a double gyroid (DG) Ti6Al4V scaffold based on a triply periodic minimal surface (TPMS) structure and investigated the osseointegration performance of DG structural scaffolds with varying porosities. Compression tests revealed that the elastic modulus and compressive strength of the DG structural scaffold were sufficient for orthopedic implants. In vitro cellular experiments demonstrated that the DG structure significantly enhanced cell proliferation, vascularization, and osteogenic differentiation compared to the cubic structure. Notably, the DG structure with a porosity of 55% Preprint of Bio-Design and Manufacturing (unedited) exhibited the most favorable outcomes. In vivo experiments in rabbits further demonstrated that DG scaffolds could promote neovascularization and bone regeneration and maturation, and DG scaffolds with a porosity of 55% performed best. Additionally, by further comparing the surface area, specific surface area per unit volume, and internal flow distribution characteristics of G-structure scaffolds and DG structure scaffolds, we found that DG structure scaffolds are more conducive to cell adhesion and growth within the scaffold. This study underscores the potential of DG scaffolds based on the TPMS structure in optimizing the pore structure design of titanium scaffolds, inducing angiogenesis, and advancing the clinical application of titanium scaffolds for repairing bone defects.
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