Harnessing the immune system for the treatment of breast cancer
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Xinguo Jiang. Harnessing the immune system for the treatment of breast cancer[J]. Journal of Zhejiang University Science B, 2014, 15(1): 1-15.
@article{title="Harnessing the immune system for the treatment of breast cancer",
author="Xinguo Jiang",
journal="Journal of Zhejiang University Science B",
volume="15",
number="1",
pages="1-15",
year="2014",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1300264"
}
%0 Journal Article
%T Harnessing the immune system for the treatment of breast cancer
%A Xinguo Jiang
%J Journal of Zhejiang University SCIENCE B
%V 15
%N 1
%P 1-15
%@ 1673-1581
%D 2014
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1300264
TY - JOUR
T1 - Harnessing the immune system for the treatment of breast cancer
A1 - Xinguo Jiang
J0 - Journal of Zhejiang University Science B
VL - 15
IS - 1
SP - 1
EP - 15
%@ 1673-1581
Y1 - 2014
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1300264
Abstract: Standard treatment options for breast cancer include surgery, chemotherapy, radiation, and targeted therapies, such as adjuvant hormonal therapy and monoclonal antibodies. Recently, the recognition that chronic inflammation in the tumor microenvironment promotes tumor growth and survival during different stages of breast cancer development has led to the development of novel immunotherapies. Several immunotherapeutic strategies have been studied both preclinically and clinically and already have been shown to enhance the efficacy of conventional treatment modalities. Therefore, therapies targeting the immune system may represent a promising next-generation approach for the treatment of breast cancers. This review will discuss recent findings that elucidate the roles of suppressive immune cells and proinflammatory cytokines and chemokines in the tumor-promoting microenvironment, and the most current immunotherapeutic strategies in breast cancer.
Full Text:
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Summary: 
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CLC number: R737.9
On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
Crosschecked: 2013-12-13
Cited: 11
Clicked: 17984
Open peer comments: Debate/Discuss/Question/Opinion
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zs@No address<No mail>
2014-02-08 11:02:53
The authors reviewed the interesting and hot topic the inflammation、immune system and Cancer and this review will help readers to know the recenlt advance concept and knowlege of this feild.
ZX@No address<No mail>
2014-02-08 11:01:43
The manuscript has a high significance for breast cancer study. The review mainly discuss a point that chronic inflammation in the tumor microenvironment promotes tumor growth and development. The effect of chronic inflammation on tumor has been a focus for recent years so the manuscript has a supernal novelty. This review may supply some important hints for immunotherapeutic strategies.