Full Text:   <2679>

Summary:  <1999>

CLC number: R711.74

On-line Access: 2024-08-27

Received: 2023-10-17

Revision Accepted: 2024-05-08

Crosschecked: 2017-02-13

Cited: 2

Clicked: 4110

Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Jing Ye

http://orcid.org/0000-0001-5976-7044

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Journal of Zhejiang University SCIENCE B 2017 Vol.18 No.3 P.249-255

http://doi.org/10.1631/jzus.B1600473


Prognostic value of human papillomavirus 16/18 genotyping in low-grade cervical lesions preceded by mildly abnormal cytology


Author(s):  Jing Ye, Bei Cheng, Yi-fan Cheng, Ye-li Yao, Xing Xie, Wei-guo Lu, Xiao-dong Cheng

Affiliation(s):  Department of Gynecologic Oncology, Women�s Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China

Corresponding email(s):   attwentyone@163.com, chengxd@zju.edu.cn

Key Words:  Low-grade squamous intraepithelial lesion (LSIL), Cervical intraepithelial neoplasia grade 1 (CIN1), Human papillomavirus (HPV), HPV16/18 genotyping, Prognostic value, Prospective study



Abstract: 
Histological low-grade squamous intraepithelial lesion/cervical intraepithelial neoplasia grade 1 (LSIL/CIN1) preceded by normal or mildly abnormal cytology is recommended for conservative follow-up, with no separated management. In this study, we assessed the triage value of human papillomavirus (HPV) 16/18 genotyping in 273 patients with LSIL/CIN1. HPV16/18 genotyping was performed at baseline and follow-up was at 6-monthly intervals for up to 2 years. At each follow-up, women positive for cytology or high-risk HPV (hrHPV) were referred for colposcopy. Enrollment cytology, HPV16/18 genotyping, and questionnaire-obtained factors were linked to the 2-year cumulative progression rate. Univariate and multivariate analyses were performed taking into account time-to-event with Cox proportional hazard regression. The results showed that 190 cases (69.6%) regressed, 37 (13.6%) persisted, and 46 (16.8%) progressed. HPV16/18 positivity (hazard ratio (HR), 2.708; 95% confidence interval (CI), 1.432–5.121; P=0.002) is significantly associated with higher 2-year cumulative progression rate. Sub-analysis by enrollment cytology and age restricted the positive association among patients preceded by mildly abnormal cytology and aged 30 years or older. Immediate treatment is a rational recommendation for the high-risk subgroup, when good compliance is not assured.

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