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Journal of Zhejiang University SCIENCE B 1998 Vol.-1 No.-1 P.

http://doi.org/10.1631/jzus.B2500181


Applications and advances of bile-based omics technologies in the diagnosis of cholangiocarcinoma


Author(s):  Taifeng ZHU1*, Jiali XING2*, Ziyue HUANG1, Shanshan WANG1, Duo LI1, Xinting SANG1, Cong NING1, Chengpei ZHU3, Yongchang ZHENG1, Haitao ZHAO1

Affiliation(s):  1Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC), Beijing 100730, China 2State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC), Beijing 100730, China 3Department of General Surgery Center, Beijing Youan Hospital, Clinical Center for Liver Cancer, Capital Medical University, Beijing 100069, China

Corresponding email(s):   Haitao ZHAO, zhaoht@pumch.cn Yongchang ZHENG, zhengyongchang@pumch.cn

Key Words:  Cholangiocarcinoma, Bile, Omics, Diagnosis


Taifeng ZHU1*, Jiali XING2*, Ziyue HUANG1, Shanshan WANG1, Duo LI1, Xinting SANG1, Cong NING1, Chengpei ZHU3, Yongchang ZHENG1, Haitao ZHAO1. Applications and advances of bile-based omics technologies in the diagnosis of cholangiocarcinoma[J]. Journal of Zhejiang University Science B, 1998, -1(-1): .

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author="Taifeng ZHU1*, Jiali XING2*, Ziyue HUANG1, Shanshan WANG1, Duo LI1, Xinting SANG1, Cong NING1, Chengpei ZHU3, Yongchang ZHENG1, Haitao ZHAO1",
journal="Journal of Zhejiang University Science B",
volume="-1",
number="-1",
pages="",
year="1998",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2500181"
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%A Jiali XING2*
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%A Duo LI1
%A Xinting SANG1
%A Cong NING1
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T1 - Applications and advances of bile-based omics technologies in the diagnosis of cholangiocarcinoma
A1 - Taifeng ZHU1*
A1 - Jiali XING2*
A1 - Ziyue HUANG1
A1 - Shanshan WANG1
A1 - Duo LI1
A1 - Xinting SANG1
A1 - Cong NING1
A1 - Chengpei ZHU3
A1 - Yongchang ZHENG1
A1 - Haitao ZHAO1
J0 - Journal of Zhejiang University Science B
VL - -1
IS - -1
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EP -
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Y1 - 1998
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2500181


Abstract: 
cholangiocarcinoma (CCA) is challenging to diagnose due to its subtle symptoms and the limited sensitivity and specificity of conventional diagnostic modalities. Therefore, there is an urgent need for more effective detection strategies. bile, a fluid directly secreted by the biliary system, offers a unique advantage in the diagnosis of CCA by providing a more precise representation of tumor-associated molecules, coupled with its relative ease of collection. The rapid advancement of omics technologies has significantly facilitated the investigation of bile samples. This review explores the applications and advancements of bile-based omics in the diagnosis of CCA from multiple perspectives, including genomics, epigenomics, transcriptomics, proteomics, metabolomics, and microbiomics, aiming to provide new theoretical foundations and technical support for the diagnosis of this malignancy.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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