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Novel multi-component synergistic bioink that balances biocompatibility and mechanical strength for cartilage regeneration
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Zijun MA1, Wendan JIA1, Xiaoyuan WANG1, Rong CHENG1, Lu HAN1, Meng LI1, Xiaoning YANG3,Shengbo SANG1,2. Novel multi-component synergistic bioink that balances biocompatibility and mechanical strength for cartilage regeneration[J]. Journal of Zhejiang University Science B, 1998, -1(-1): .
@article{title="Novel multi-component synergistic bioink that balances biocompatibility and mechanical strength for cartilage regeneration",
author="Zijun MA1, Wendan JIA1, Xiaoyuan WANG1, Rong CHENG1, Lu HAN1, Meng LI1, Xiaoning YANG3,Shengbo SANG1,2",
journal="Journal of Zhejiang University Science B",
volume="-1",
number="-1",
pages="",
year="1998",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2500343"
}
%0 Journal Article
%T Novel multi-component synergistic bioink that balances biocompatibility and mechanical strength for cartilage regeneration
%A Zijun MA1
%A Wendan JIA1
%A Xiaoyuan WANG1
%A Rong CHENG1
%A Lu HAN1
%A Meng LI1
%A Xiaoning YANG3
%A Shengbo SANG1
%A 2
%J Journal of Zhejiang University SCIENCE B
%V -1
%N -1
%P
%@ 1673-1581
%D 1998
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2500343
TY - JOUR
T1 - Novel multi-component synergistic bioink that balances biocompatibility and mechanical strength for cartilage regeneration
A1 - Zijun MA1
A1 - Wendan JIA1
A1 - Xiaoyuan WANG1
A1 - Rong CHENG1
A1 - Lu HAN1
A1 - Meng LI1
A1 - Xiaoning YANG3
A1 - Shengbo SANG1
A1 - 2
J0 - Journal of Zhejiang University Science B
VL - -1
IS - -1
SP -
EP -
%@ 1673-1581
Y1 - 1998
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2500343
Abstract: Hydrogels, owing to their porous network structure resembling the extracellular matrix (ECM), have become essential scaffold materials in the field of cartilage tissue engineering. Among them, gelatin methacrylate (GelMA) hydrogels are widely used in bioink development due to their excellent biocompatibility, biodegradability and tunable photo crosslinking properties. However, the high biocompatibility of pure GelMA often comes at the cost of mechanical strength, limiting its applicability in cartilage regeneration. To overcome this trade-off, this study developed composite bioinks based on GelMA, silk fibroin (SF) and polyethylene oxide (PEO) for fabricating porous hydrogel scaffolds, which were then systematically characterized in terms of morphology, porosity, hydrophilicity, mechanical strength, rheological behavior, printability, and cytocompatibility. In this design, PEO serves as a porogen to generate highly porous structures (porosity up to 88%), while SF compensates for the mechanical loss caused by PEO, enabling the scaffold to retain a compression strength of up to 29.10?kPa. Among the tested formulations, the 10% GelMA/1% SF/1.5% (1%=0.01 g/mL) PEO bioink exhibited excellent printability, mechanical integrity and cytocompatibility, and it supported a robust deposition of collagen II and aggrecan by chondrocytes after printing. This work provides a versatile strategy for balancing the biocompatibility and mechanical robustness in bioinks, offering a promising platform for next-generation cartilage tissue engineering scaffolds.
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