Full Text:
<2283>
CLC number: O621
On-line Access:
Received: 1998-03-09
Revision Accepted: 1999-05-26
Crosschecked: 0000-00-00
Cited: 8
Clicked: 4893
FACILE SYNTHESIS OF 4β-AMINOPODOPHYLLOTOXINS
| |||||||||||||
CHEN Shao-yuan, YU Yong-ping, GONG Xing-guo, CHEN Yao-zu. FACILE SYNTHESIS OF 4β-AMINOPODOPHYLLOTOXINS[J]. Journal of Zhejiang University Science A, 2000, 1(1): 27-28.
@article{title="FACILE SYNTHESIS OF 4β-AMINOPODOPHYLLOTOXINS",
author="CHEN Shao-yuan, YU Yong-ping, GONG Xing-guo, CHEN Yao-zu",
journal="Journal of Zhejiang University Science A",
volume="1",
number="1",
pages="27-28",
year="2000",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.2000.0027"
}
%0 Journal Article
%T FACILE SYNTHESIS OF 4β-AMINOPODOPHYLLOTOXINS
%A CHEN Shao-yuan
%A YU Yong-ping
%A GONG Xing-guo
%A CHEN Yao-zu
%J Journal of Zhejiang University SCIENCE A
%V 1
%N 1
%P 27-28
%@ 1869-1951
%D 2000
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2000.0027
TY - JOUR
T1 - FACILE SYNTHESIS OF 4β-AMINOPODOPHYLLOTOXINS
A1 - CHEN Shao-yuan
A1 - YU Yong-ping
A1 - GONG Xing-guo
A1 - CHEN Yao-zu
J0 - Journal of Zhejiang University Science A
VL - 1
IS - 1
SP - 27
EP - 28
%@ 1869-1951
Y1 - 2000
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2000.0027
Abstract: 4β-amino-4-desoxypodophyllotoxin and 4β-amino-4'-demethyl-4desoxypodophyllo-toxin were synthesized by reduction of the corresponding 4β-azidopodophyllotoxin derivatives with HCO2NH4/Pd-C in excellent yields under convenient and mild reactive condition.
[1]Estape, J., Milla, A., 1982. Review of the clinical activities of VP-16. New Approaches in Cancer Therapy,15:692.
[2]Kuhu, M., Kell,J.C., Von,W.A., 1969. Uber ein neues glykosidierungsverfahhren II. Glykoside des 4'-Demethylepipodophyllotoxins. Helv.Chim.Acta, 52:944.
[3]Lee, K. H., Wang, H. K., 1995. Current status of bioanalysis of etoposide and related compounds. Yaowu Shipin Fenx,3(4):209-32.
[4]Lee, K. H., Cheng, Y. C., Zhang, Y. L., 1995. 4β-amino-podophyllotoxin analogcompounds for treating tumors and methods of synthesis and use. U.S. Patent, US5300,500(Cl. 514-232,5;A61K31/535).
[5]Pan, J. L., Wang, Y. G., Chen, Y. Z., 1997. Synthesis and antitumor activity of new derivatives of podophyllotoxin. Current Sciences,72(4):268.
[6]Siya, R., Richard, E. E., 1988. Ammonium formate in organic synthesis: A versatile agent in catalytic hydrogen transfer reductions. Synthesis, 91 and reference therein 312.
[7]Tian, X., Wang, Y.G., Yang, et al., 1997. Synthesis and antitumor activity of spin labeled derivatives of podophyllotoxin. Life Sci. 60: 511.
Open peer comments: Debate/Discuss/Question/Opinion
<1>