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Journal of Zhejiang University SCIENCE A 2004 Vol.5 No.8 P.956~959

http://doi.org/10.1631/jzus.2004.0956


Cleaner and convenient preparation of 3-(4,6-dimethoxy-pyrimidin-2-yloxy)-2-methyl-phenol


Author(s):  WEN Yue-zhong, FANG Zhao-hua, LIU Wei-ping

Affiliation(s):  Institute of Environmental Science, College of Environmental & Resource Sciences, Zhejiang University, Hangzhou 310029, China

Corresponding email(s):   wenyuezhong@zjuem.zju.edu.cn

Key Words:  Cleaner preparation, Greener technology, Selective synthesis, 2-methyl-benzene-1, 3-diol, 3-(4, 6-dimethoxy-pyrimidin-2-yloxy)-2-methyl-phenol


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WEN Yue-zhong, FANG Zhao-hua, LIU Wei-ping. Cleaner and convenient preparation of 3-(4,6-dimethoxy-pyrimidin-2-yloxy)-2-methyl-phenol[J]. Journal of Zhejiang University Science A, 2004, 5(8): 956~959.

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doi="10.1631/jzus.2004.0956"
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Abstract: 
Environmental concerns have highlighted the need of cleaner technologies. A cleaner, convenient and selective technology has been developed for the preparation of 3-(4,6-dimethoxy-pyrimidin-2-yloxy)-2-methyl-phenol (DPMP) from 2-methyl-benzene-1,3-diol in water as solvent. The isolated yield of DPMP is up to 86% in good selectivity. The product structure was characterized by conventional methods, 1H-NMR and MS. This technology belongs to the modern concept of environmentally friendly low wastes or non-wastes technology (LWNWT).

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference

[1] Lin, J., Huang, H., 1992. Mono-alkylation of 4,4’-biphenyldiol. Chinese Journal of Applied Chemistry, 9(6):110-112 (in Chinese).

[2] Mckillop, A., Fiaud, J.C., Hug, R.P., 1974. The use of phase-transfer catalysis for the synthesis of phenol ethers. Tetrahedron, 30:1379-1382.

[3] Muthusburamanian, L., Rao, V.S.S., Mitra, R., 2003. Convenient synthesis of methylene biothiocyanate as microbiocide. Journal of Cleaner Production, 11:695-693.

[4] Rao, J.R., Chandrababu, N.K., Maralidharan, C., Nair, B.U., Ramasami, P.G., Rao, T., 2003. Recouping the waste: a way forward for cleaner leather processing. Journal of Cleaner Production, 11:591-599.

[5] Xiao, G., Chong, Y., Hong, T., 1999. Diethlyeneglycol monobutylether synthesized by diethlyeneglycol etheration. Journal of Fushun Petroleum Institute, 19(1):3-5 (in Chinese).

[6] Zhao, Z.Z., Zhou, J., Lu, G., 1984. The Protection Groups in Organic Reactions. Science Press, Beijing (in Chinese).

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