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Journal of Zhejiang University SCIENCE A 2004 Vol.5 No.12 P.1524~1527

http://doi.org/10.1631/jzus.2004.1524


Preparation of natural α-tocopherol from non-α-tocopherols


Author(s):  YANG Yi-wen, WEN Guang-dong, WU Cai-juan, REN Qi-long, WU Ping-dong

Affiliation(s):  National Laboratory of Secondary Resources Chemical Engineering, Zhejiang University, Hangzhou 310027, China

Corresponding email(s):   ceywyang@zju.edu.cn

Key Words:  Tocopherol, Conversion, Hydroxymethylation, Hydrogenolysis


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YANG Yi-wen, WEN Guang-dong, WU Cai-juan, REN Qi-long, WU Ping-dong. Preparation of natural α-tocopherol from non-α-tocopherols[J]. Journal of Zhejiang University Science A, 2004, 5(12): 1524~1527.

@article{title="Preparation of natural α-tocopherol from non-α-tocopherols",
author="YANG Yi-wen, WEN Guang-dong, WU Cai-juan, REN Qi-long, WU Ping-dong",
journal="Journal of Zhejiang University Science A",
volume="5",
number="12",
pages="1524~1527",
year="2004",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.2004.1524"
}

%0 Journal Article
%T Preparation of natural α-tocopherol from non-α-tocopherols
%A YANG Yi-wen
%A WEN Guang-dong
%A WU Cai-juan
%A REN Qi-long
%A WU Ping-dong
%J Journal of Zhejiang University SCIENCE A
%V 5
%N 12
%P 1524~1527
%@ 1869-1951
%D 2004
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2004.1524

TY - JOUR
T1 - Preparation of natural α-tocopherol from non-α-tocopherols
A1 - YANG Yi-wen
A1 - WEN Guang-dong
A1 - WU Cai-juan
A1 - REN Qi-long
A1 - WU Ping-dong
J0 - Journal of Zhejiang University Science A
VL - 5
IS - 12
SP - 1524
EP - 1527
%@ 1869-1951
Y1 - 2004
PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.2004.1524


Abstract: 
Non-α-tocopherols are hydroxymethylated and hydrogenated to produce α-tocopherol in one pot process by simultaneously reacting with paraformaldehyde and hydrogen in the presence of catalysts of benzenesulfonic acid and 5% Pd/C in an autoclave. Effects of various operation conditions have been studied. The preferable reaction conditions are: temperature 180 °C to 200 °C, pressure 5.0 MPa, acid concentration 0.5 g/100 ml ethanol, mass ratio of Pd/C to tocopherols 7.1 g/100 g, and reaction time 5.0 h. A product with α-tocopherol content of 80% was obtained by using a raw material with a total tocopherols content of 80.54%. The conversion of non-α-tocopherols is almost 100%, and the mole yield of α-tocopherol is more than 90%.

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Reference

[1] Baldwin, W.S., Willging, S.M., Siegel, B.M., 1990. Production of D-alpha-Tocopherol from Natural Plant Sources. US 4,977,282.

[2] Breuninger, M., 1999. Process for Permethylating non-α-Tocopherols to Produce α-Tocopherol. US 5,932,748.

[3] Brüggemann, K., Herguijuela, J.R., Netscher, T., Riegl, J., 1999. Hydroxymethylation of Tocopherols. US 5,892,058.

[4] Dutta-Roy, A.K., 1999. Molecular mechanism of cellular uptake and intracellular translocation of α-tocopherol: role of tocopherol-binding proteins. Food and Chemical Toxicology, 37:967-971.

[5] Hickman, K.C.D., Weisler, L., 1949. Vitamin E Preparation. US 2,486,540.

[6] Kamal-Eldin, A., Appelqvist, L., 1996. The chemistry and antioxidant properties of tocopherols and tocotrienols. Lipids, 31(7):671-701.

[7] Lechtken, P., Hoercher, U., Jessel, B., 1990. Preparation of D-α-Tocopherol from Natural Intermediates. US 4,925,960.

[8] Müller, R.K., Schneider, H., 2000. Aminomethylation of Tocopherols. US 6,066,731.

[9] Weisler, L., Chechak, A.J., 1949. Simultaneous Haloalkylation and Reduction of Organic Compounds. US 2,486,542.

Open peer comments: Debate/Discuss/Question/Opinion

<1>

Guo shijie<502756311@qq.com>

2015-03-21 15:28:59

Please help me finish this task

Pooja@No address<pooja@matrixuniversal.com>

2013-06-19 13:07:42

Dear Sir



I would like to have full content of this article.



Kindly let me know the relevant details.



Kunal S.@No address<kunalsikchi@gmail.com>

2013-06-19 12:48:09

I am a student working on Tocopherols and its derivatives. WOuld be glad to recieve this patent to study the same. Thank you.

Anonymous@No address<No mail>

2011-10-13 10:03:35

good artical

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