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Received: 2004-07-19

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Journal of Zhejiang University SCIENCE B 2005 Vol.6 No.1 P.22-27


Investigating the role of 99mTc-TRODAT-1 SPECT imaging in idiopathic Parkinson’s disease

Author(s):  GENG Yu, SHI Guo-hua, JIANG Yun, XU Ling-xun, HU Xing-yue, SHAO Yu-quan

Affiliation(s):  Department of Neurology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China; more

Corresponding email(s):   gengyu2001@yahoo.com.cn

Key Words:  99mTc-TRODAT-1, Single photon emission computed tomography (SPECT), Parkinson&rsquo, s disease (PD)

GENG Yu, SHI Guo-hua, JIANG Yun, XU Ling-xun, HU Xing-yue, SHAO Yu-quan. Investigating the role of 99mTc-TRODAT-1 SPECT imaging in idiopathic Parkinson’s disease[J]. Journal of Zhejiang University Science B, 2005, 6(1): 22-27.

@article{title="Investigating the role of 99mTc-TRODAT-1 SPECT imaging in idiopathic Parkinson’s disease",
author="GENG Yu, SHI Guo-hua, JIANG Yun, XU Ling-xun, HU Xing-yue, SHAO Yu-quan",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Investigating the role of 99mTc-TRODAT-1 SPECT imaging in idiopathic Parkinson’s disease
%A SHI Guo-hua
%A XU Ling-xun
%A HU Xing-yue
%A SHAO Yu-quan
%J Journal of Zhejiang University SCIENCE B
%V 6
%N 1
%P 22-27
%@ 1673-1581
%D 2005
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2005.B0022

T1 - Investigating the role of 99mTc-TRODAT-1 SPECT imaging in idiopathic Parkinson’s disease
A1 - GENG Yu
A1 - SHI Guo-hua
A1 - JIANG Yun
A1 - XU Ling-xun
A1 - HU Xing-yue
A1 - SHAO Yu-quan
J0 - Journal of Zhejiang University Science B
VL - 6
IS - 1
SP - 22
EP - 27
%@ 1673-1581
Y1 - 2005
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2005.B0022

Objective: To investigate the role of 99mTc-TRODAT-1 SPECT in diagnosis and assessing severity of idiopathic parkinson&rsquo;s disease (PD). Methods: Thirty-eight patients with primary, tentative diagnosis of PD and eighteen age-matched normal controls were studied with 99mTc-TRODAT-1 SPECT imaging. The regions of interests (ROIs) were drawn manually on cerebellum (CB), occipital cortex (OC) and three transverse plane slice-views of striatums, the semiquantitative BG (background)/[(OC+CB)/2] were then calculated. Results: A lower uptake of 99mTc-TRODAT-1 in striatums were displayed in thirty-six out of thirty-eight PD patients by visual inspection, compared to controls. In twenty-four PD cases with (Hoehn and Yahr scale) HYS stage I, a greater loss of DAT uptake was found in striatum and its subregions contralateral striatum to the affected limbs than in the same regions of the controls, although the striatal uptake was bilaterally reduced. Using Spearman correlation analysis showed that the reduction of the uptake ratios significantly correlated with the UPDRS in striatum and all its subregions in the PD group (P<0.05), a similar change was also found in the putamen by using the rating scale of Hoehn and Yahr (P<0.05). However, analysis of variance (ANOVA) did not show any relationship between the decreasing uptake of 99mTc-TRODAT-1 and increasing severity of PD patients, although the specific uptake of 99mTc-TRODAT-1 was continuously decreased in the striatum by visual inspection with the progress of PD from HYS stage I to III. Conclusion: 99mTc-TRODAT-1 SPECT imaging may serve as a useful method for improving the correct diagnosis of PD. In assessing the role of 99mTc-TRODAT-1 SPECT in disease severity of PD, UPDRS can offer a comprehensive index, although the Hoehn and Yahr assessment may be available in part.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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