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Received: 2004-06-07

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Journal of Zhejiang University SCIENCE B 2005 Vol.6 No.4 P.259~264


Abnormal cortical functional connections in Alzheimer’s disease: analysis of inter- and intra-hemispheric EEG coherence

Author(s):  JIANG Zheng-yan

Affiliation(s):  Department of Psychiatry, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China

Corresponding email(s):   Jiang_zju@mail.hz.zj.cn

Key Words:  Alzheimer&rsquo, s disease (AD), Electroencephalography (EEG), Coherence, Photic stimulation, Cortical connectivity

JIANG Zheng-yan. Abnormal cortical functional connections in Alzheimer’s disease: analysis of inter- and intra-hemispheric EEG coherence[J]. Journal of Zhejiang University Science B, 2005, 6(4): 259~264.

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author="JIANG Zheng-yan",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Abnormal cortical functional connections in Alzheimer’s disease: analysis of inter- and intra-hemispheric EEG coherence
%A JIANG Zheng-yan
%J Journal of Zhejiang University SCIENCE B
%V 6
%N 4
%P 259~264
%@ 1673-1581
%D 2005
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2005.B0259

T1 - Abnormal cortical functional connections in Alzheimer’s disease: analysis of inter- and intra-hemispheric EEG coherence
A1 - JIANG Zheng-yan
J0 - Journal of Zhejiang University Science B
VL - 6
IS - 4
SP - 259
EP - 264
%@ 1673-1581
Y1 - 2005
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2005.B0259

To investigate inter- and intra-hemispheric electroencephalography (EEG) coherence at rest and during photic stimulation of patients with alzheimer&rsquo;s disease (AD). Thirty-five patients (12 males, 23 females; 52~64 y) and 33 sex- and age-matched controls (12 males, 21 females; 56~65 y) were recruited in the present study. EEG signals from C3-C4, P3-P4, T5-T6 and O1-O2 electrode pairs resulted from the inter-hemispheric action, and EEG signals from C3-P3, C4-P4, P3-O1, P4-O2, C3-O1, C4-O2, T5-O1 and T6-O2 electrode pairs resulted from the intra-hemispheric action. The influence of inter- and intra-hemispheric coherence on EEG activity with eyes closed was examined, using fast Fourier transformation from the 16 sampled channels. The frequencies of photic stimulation were fixed at 5, 10 and 15 Hz, respectively. The general decrease of AD patients in inter- and intra-hemispheric EEG coherence was more significant than that of the normal controls at the resting EEG, with most striking decrease observed in the alpha-1 (8.0-9.0 Hz) and alpha-2 (9.5-12.5 Hz) bands. During photic stimulation, inter- and intra-hemispheric EEG coherences of the AD patients having lower values in the alpha (9.5-10.5 Hz) band than those of the control group. It suggests that under stimulated and non-stimulated conditions, AD patients had impaired inter- and intra-hemispheric functional connections, indicating failure of brain activation in alpha-related frequency.

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