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Journal of Zhejiang University SCIENCE B 2005 Vol.6 No.7 P.682~685

http://doi.org/10.1631/jzus.2005.B0682


The treatment of relapsing primary nephrotic syndrome in children


Author(s):  Wang Ya-ping, Liu Ai-min, Dai Yu-wen, Yang Cheng, Tang Hong-feng

Affiliation(s):  Affiliated Children’ more

Corresponding email(s):   yaping_wang163@163.com

Key Words:  Primary nephrotic syndrome, Relapse, Tripterysium glucosides, Prednisone


Wang Ya-ping, Liu Ai-min, Dai Yu-wen, Yang Cheng, Tang Hong-feng. The treatment of relapsing primary nephrotic syndrome in children[J]. Journal of Zhejiang University Science B, 2005, 6(7): 682~685.

@article{title="The treatment of relapsing primary nephrotic syndrome in children",
author="Wang Ya-ping, Liu Ai-min, Dai Yu-wen, Yang Cheng, Tang Hong-feng",
journal="Journal of Zhejiang University Science B",
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number="7",
pages="682~685",
year="2005",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.2005.B0682"
}

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%T The treatment of relapsing primary nephrotic syndrome in children
%A Wang Ya-ping
%A Liu Ai-min
%A Dai Yu-wen
%A Yang Cheng
%A Tang Hong-feng
%J Journal of Zhejiang University SCIENCE B
%V 6
%N 7
%P 682~685
%@ 1673-1581
%D 2005
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2005.B0682

TY - JOUR
T1 - The treatment of relapsing primary nephrotic syndrome in children
A1 - Wang Ya-ping
A1 - Liu Ai-min
A1 - Dai Yu-wen
A1 - Yang Cheng
A1 - Tang Hong-feng
J0 - Journal of Zhejiang University Science B
VL - 6
IS - 7
SP - 682
EP - 685
%@ 1673-1581
Y1 - 2005
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2005.B0682


Abstract: 
Objective: To explore better therapy and reduce the rate of re-relapse of primary nephritic syndrome in children who had been treated with corticosteroids but relapsed. Methods: Eighty relapsers were enrolled from Jan. 1994 to Apr. 2000, who were randomly divided into two groups. The treatment group (n=39) had been treated with tripterysium glucosides for three months, with the control group (n=41) members were treated with cyclophosphmide (CTX) by intermission intravenous pulse, with total dose of CTX not being more than 150 mg/kg. prednisone, meanwhile, was given to both groups. The total treatment period of prednisone was prolonged by 12-18 months. Results: After following up for 3–7 years, the re-relapse rates of both groups were observed. The re-relapse rate of the treatment group was 28.2% to 29.3% in the CTX-controlled group. The re-relapse rates between two groups were almost similar, and with no observed significant difference (P>0.05). The side effect of tripterysium glucosides was less than that of CTX. Conclusion: For the treatment of relapsing nephritic syndrome in children, the combination of tripterysium glucosides and prolonged corticosteroid therapy is as effective as the regimen of CTX plus prolonged use of prednisone.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference

[1] Hodson, E.M., Knight, J.F., Willis, N.S., Craig, J.C., 2000. Corticosteroid therapy for nephrotic syndrome in children. Arch Dis Child, 83(3):45-51.

[2] Liu, D., Yang, J.W., Chen, Z.H., Dai, C.S., Liu, Z.H., Li, L.S., 1999. Relationship between cell cycle and apoptosis of activated T lymphocyctes induced by triptolide. Chin J Immun, 15(10):455-459.

[3] Mendoia, S.A., Tune, B.M., 1995. Management of the difficult nephrotic patients. Pediatr-Clin-Am, 42:1459-1468.

[4] Qiu, D., Kao, P.N., 2003. Immunosupressive and anti-inflammatory mechanisms of triptolide, the principle active diterpenoid from Chinese medicinal herb Tripterygium Wilfordii Hookf. Drugs RD, 4(1):1-18.

[5] Takcda, A., Takimoto, H., Mizusawa, Y., Simosa, M., 2001. Prediction of subsequent relapse in children with steroid-sensitive nephrotic syndrome. Pediatr-Nephrol, 16:888-893.

[6] Yang, J.Y., 2000. Considerations in clinical diagnosis, treatment and research of nephrotic syndrome. Chin J Pediatr, 38(5):280-281.

[7] Yap, H.K., Han, E.J., Heng, C.K., Gong, W.K., 2001. Risk factors for steroid dependency in children with idiopathic nephrotic syndrome. Pediatr-Nephrol, 16:1049-1052.

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