Full Text:   <3532>

CLC number: TQ4

On-line Access: 

Received: 2008-07-06

Revision Accepted: 2008-10-10

Crosschecked: 2009-04-23

Cited: 2

Clicked: 3648

Citations:  Bibtex RefMan EndNote GB/T7714

-   Go to

Article info.
1. Reference List
Open peer comments

Journal of Zhejiang University SCIENCE A 2009 Vol.10 No.5 P.739~745

http://doi.org/10.1631/jzus.A0820516


Enhancement of solubility and mass transfer coefficient of salicylic acid through hydrotropy


Author(s):  S. THENESHKUMAR, D. GNANAPRAKASH, N. NAGENDRA GANDHI

Affiliation(s):  Department of Chemical Engineering, St. Peter’ more

Corresponding email(s):   n_nagendra2002@yahoo.com

Key Words:  Hydrotropy, Hydrotropes, Solubilization, Mass transfer coefficient, Separation


S. THENESHKUMAR, D. GNANAPRAKASH, N. NAGENDRA GANDHI. Enhancement of solubility and mass transfer coefficient of salicylic acid through hydrotropy[J]. Journal of Zhejiang University Science A, 2009, 10(5): 739~745.

@article{title="Enhancement of solubility and mass transfer coefficient of salicylic acid through hydrotropy",
author="S. THENESHKUMAR, D. GNANAPRAKASH, N. NAGENDRA GANDHI",
journal="Journal of Zhejiang University Science A",
volume="10",
number="5",
pages="739~745",
year="2009",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.A0820516"
}

%0 Journal Article
%T Enhancement of solubility and mass transfer coefficient of salicylic acid through hydrotropy
%A S. THENESHKUMAR
%A D. GNANAPRAKASH
%A N. NAGENDRA GANDHI
%J Journal of Zhejiang University SCIENCE A
%V 10
%N 5
%P 739~745
%@ 1673-565X
%D 2009
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.A0820516

TY - JOUR
T1 - Enhancement of solubility and mass transfer coefficient of salicylic acid through hydrotropy
A1 - S. THENESHKUMAR
A1 - D. GNANAPRAKASH
A1 - N. NAGENDRA GANDHI
J0 - Journal of Zhejiang University Science A
VL - 10
IS - 5
SP - 739
EP - 745
%@ 1673-565X
Y1 - 2009
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.A0820516


Abstract: 
This study deals with the effect of hydrotropes on the solubility and mass transfer coefficient of salicylic acid. The solubility and mass transfer studies were performed using the hydrotropes, i.e., sodium acetate, sodium salicylate, citric acid, and urea at concentrations of 0~3.0 mol/L and system temperatures of 303~333 K. It was found that the solubility and mass transfer coefficient of salicylic acid increases with increase in hydrotrope concentration and also with system temperature. All hydrotropes used in this work showed an enhancement in solubility and mass transfer coefficient to different degrees. The maximum enhancement factor values were determined for all hydrotropes used in this study. The highest value was 28.08 for solubility studies and 10.42 for mass transfer studies. The performance of hydrotropes was measured in terms of the Setschenow constant (Ks). The highest value observed was 0.696.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference

[1] Agarwal, M., Gaikar, V.G., 1992. Extractive separation using hydrotropes. Separations Technology, 2(2):79-84.

[2] Agrawal, S., Pancholi, S.S., Jain, N.K., Agrawal, G.P., 2004. Hydrotropic solubilization of nimesulide for parenteral administration. International Journal of Pharmaceutics, 274(1-2):149-155.

[3] Ahuja, N., Katare, O.P., Singh, B., 2007. Studies on dissolution enhancement and mathematical modeling of drug release of a poorly water-soluble carrier. European Journal of Pharmaceutics and Biopharmaceutics, 65:26-38.

[4] Badwan, A.A., Ei-Khordagui, L.K., Salesh, A.M., 1982. The solubility of benzodiazepines in sodium salicylate solutions and proposed mechanism for hydrotropic solubilization. International Journal of Pharmaceutics, 13(1):67-74.

[5] Balasubramanian, D., Srinivas, V., Gaikar, V.G., Sharma, M., 1989. Aggregation beaviour of hydrotropic compounds in aqueous solutions. The Journal of Physical Chemistry, 93(9):3865-3870.

[6] Barbosa, S., Taboada, P., Castro, E., Mosquera, V., 2006. Influence of SDS and two anionic hydrotropes on the micellized state of the triblock copolymer E71G7E71. Journal of Colloid and Interface Science, 296(2):677-684.

[7] Bauduin, P., Renoncourt, A., Kopf, A., Touraud, D., Kunz, W., 2005. Unified concept of solubilization in water by hydrotropes and cosolvents. Langmuir, 21(15):6769-6775.

[8] Colonia, E.J., Dixit, A.B., Tavare, N.S., 1998. Phase relations of o- and p-chlorobenzoic acids in hydrotrope solutions. Journal of Chemical & Engineering Data, 43(2):220-225.

[9] Cheng, H.F., Sabatini, D.A., 2007. Separation of organic compounds from surfactant solution: a review. Separation Science and Technology, 42(3):453-475.

[10] Dandekar, D.V., Jayaprakasha, G.K., Patil, B.S., 2008. Hydrotropic extraction of bioactive limonin from sour orange (Citrius aurantium L.) seeds. Food Chemistry, 109(3):515-520.

[11] Evstigneev, M.P., Evstigneev, V.P., Hernandez Santiago, A.A., Davies, D.B., 2006. Effect of a mixture of caffeine and nicotinamide on the solubility of vitamin (B2) in aqueous solution. European Journal of Pharmaceutical Sciences, 28(1-2):59-66.

[12] Friberg, S.E., 1997. Hydrotropes. Surface Physics, 2:490-494.

[13] Friberg, S.E., Blute, I., 2006. Hydrotropy. Surfactant Science Series 129 (Liquid Detergents) (2nd Ed.). CRC Press, p.19-38.

[14] Friberg, S.E., Brancewicz, C., 1994. O/W microemulsions and hydrotropes: the coupling action of a hydrotrope. Langmuir, 10(9):2945-2949.

[15] Friberg, S.E., Yang, J., Huang, T., 1996. A reversible extraction process of phenyl ethyl alcohol, a fragrance. Industrial & Engineering Chemistry Research, 35(9):2856-2859.

[16] Gaikar, V.G., Padalkar, V.K., 2008. Characterization of mixed of structural isomers of sodium butyl benzene sulfonate and sodium dodecyl sulphate by SANS, FTIR spectroscopy and NMR spectroscopy. Journal of Molecular Liquids, 138(1-3):155-167.

[17] Gaikar, V.G., Phatak, P.V., 1999. Selective solubilization of isomers in hydrotrope solution o-/p-chlorobenzoic acids and o-/p-nitro anilines. Separation Science and Technology, 34(3):439-459.

[18] Gaikar, V.G., Sharma, M.M., 1986. Extractive separation with hydrotropes. Solvent Extraction and Ion Exchange, 4(4):839-846.

[19] Gandhi, N.N., Kumar, D.M., 2000. Effect of hydrotropes on solubility and mass transfer coefficient of amyl acetate. Bioprocess and Biosystems Engineering, 23(1):31-36.

[20] Gandhi, N.N., Kumar, D.M., Sathyamurthy, N., 1998a. Effect of hydrotropes on solubility and mass transfer coefficient of butyl acetate. Journal of Chemical & Engineering Data, 43(5):695-699.

[21] Gandhi, N.N., Kumar, D.M., Sathyamurthy, N., 1998b. Effect of hydrotropes on solubility and mass transfer coefficient enhancement of ethyl benzoate. Journal of Chemical & Engineering Data, 26:63-68.

[22] Gandhi, N.N., Kumar, D.M., Sathyamurthy, N., 2000. Effect of hydrotropes on solubility and mass transfer coefficient of butyl acetate. Journal of Chemical & Engineering Data, 45(3):419-423.

[23] Hodgdon, T.K., Kaler, E.W., 2007. Hydrotropic solutions. Current Opinion in Colloid and Interface Science, 12(3):121-128.

[24] Huh, K.M., Lee, S.C., Cho, Y.W., Lee, J., Jeong, J.H., Park, K., 2005. Hydrotropic polymer micelle system for delivery of paclitaxel. Journal of Controlled Release, 101(1-3):59-68.

[25] Jain, A.K., 2008. Solubilization of indomethacin using hydrotropes for aqeous injection. European Journal of Pharmaceutics and Biopharmaceutics, 68(3):701-714.

[26] John, A.D., 1987. Lange’s Handbook of Chemistry. McGraw-Hill, New York, p.7-347.

[27] Kim, T.H., Choi, S.M., Kline, S.R., 2006. Polymerized rodlike nanoparticles with controlled surface charge density. Langmuir, 22(6):2844-2850.

[28] Kumar, S., Parveen, N., Kabir-ud-Din., 2005. Additive-induced association in unconventional systems: a case of the hydrotrope. Journal of Surfactants and Detergents, 8(1):109-114.

[29] Laxman, M., Sharma, M.M., 1990. Reduction of isophorone with borohydride: change in regio selectivity with hydrotropes. Synthetic Communications, 20(1):111-117.

[30] Mahapatra, A., Gaikar, V.G., Sharma, M.M., 1988. New strategies in extractive distillation: use of aqueous solution of hydrotropes and organic bases as solvent for organic acids. Separation Science and Technology, 23(4):429-436.

[31] Maheshwari, R.K., 2006. Novel application of hydrotopic solubilization in the analysis of bulk sample of ketoprofen and salicylic acid. Asian Journal of Chemistry, 18:393-396.

[32] Maheshwari, R.K., Ajmera, A., 2006. A novel application of hydrotopic solubilization in the quantitative analysis of bulk sample of ketoprofen and frusemide. Asian Journal of Pharmaceutics, 1:60-62.

[33] Maheshwari, R.K., Jain, N.K., Chaturvedi, S.C., 2006. Titrimetric analysis of aceclofenac in tablets using hydrotropic solubilization technique. Indian Drug, 43:516-518.

[34] Mansur, C.R.E., Pires, R.V., Gonzalez, G., Lucas, E.F., 2005. Influence of the hydrotrope structure on the physical chemical properties of polyoxide aqueous solutions. Langmuir, 21(7):2696-2703.

[35] Meyyappan, N., Gandhi, N.N., 2004. Solubility and mass transfer coefficient enhancement of benzyl acetate in water through hydrotropy. Journal of Chemical & Engineering Data, 49(5):1290-1294.

[36] Meyyappan, N., Nagendra, G.N., 2005. Solubility and mass transfer coefficient enhancement of benzyl benzotate in water through hydrotropy. Journal of Chemical & Engineering Data, 50(3):796-800.

[37] Neumann, M.G., Schmitt, C.C., Prieto, K.R., Goi, B.E., 2007. The photophysical determination of the minimum hydrotrope concentration of aromatic hydrotropes. Journal of Colloid and Interface Science, 315(2):810-813.

[38] Neuberg, C., 1916. Hydrotropy. Biochemische Zeitschrift, 76:107-108.

[39] Nicoli, S., Zani, F., Bilzi, S., Bettini, R., Santi, P., 2008. Association of nicotinamide with parabens: effect of solubility, partition and transdermal permeation. European Journal of Pharmaceutics and Biopharmaceutics, 69:613-621.

[40] Ooya, T., Moo, H.K., Saitoh, M., Tamiya, E., Park, K., 2005. Self-assembly of cholesterol-hydrotropic dendrimers conjugates into micelle-like structure: preparation and hydrotropic solubilization of paclitaxel. Science and Technology of Advanced Materials, 6(5):452-456.

[41] Perry, R.H., 1997. Perry’s Chemical Engineer’s Handbook (7th Ed.). McGraw-Hill, New York, p.2-45.

[42] Phatak, P.V., Gaikar, V.G., 1993. Solubility o- and p-chlorobenzoic acid in hydrotrope solutions. Journal of Chemical & Engineering Data, 38(2):217-220.

[43] Raynaud-Lacroze, P.O., Tavare, N.S., 1993. Separation of 2-napthol: hydrotropy and precipitation. Industrial & Engineering Chemistry Research, 32(4):685-691.

[44] Rigoli, I.C., Schmitt, C.C., Neumann, M.G., 2007. The hydrotrope effect on the photopolymerization of styrenesulfonate initiated by Ru complexes. Journal of Photochemistry and Photobiology A: Chemistry, 188(2-3):329-333.

[45] Sharma, D.K., Joshi, S.B., 2007. Solubility enhancement strategies for poorly water soluble drugs in solid dispersion: a review. Asian Journal of Pharmaceutics, 1:9-14.

[46] Souza, T.P., Zanette, D., Kawanami, A.E., Rezende, L., Ishiki, H.M., Amaral, A.T., 2006. pH at the micellar interface: synthesis of pH probes derived from salicylic acid, acid-base dissociation in sodium dodecyl sulfate micelles, and Poisson-Boltzmann simulation. Journal of Colloid and Interface Science, 297(1):292-302.

[47] Tavare, N.S., Gaikar, V.G., 1991. Precipitation of salicylic acid: hydrotropy and reaction. Industrial & Engineering Chemistry Research, 30(4):722-728.

[48] Vikrant, B.W., Prajesh, S.K., Vilas, G.G., 2007. Effect of temperature on aggregation behaviour of aqueous solution of sodium cumene sulfonate. Journal of Molecular Liquids, 133(1-3):68-76.

Open peer comments: Debate/Discuss/Question/Opinion

<1>

Please provide your name, email address and a comment





Journal of Zhejiang University-SCIENCE, 38 Zheda Road, Hangzhou 310027, China
Tel: +86-571-87952783; E-mail: cjzhang@zju.edu.cn
Copyright © 2000 - Journal of Zhejiang University-SCIENCE