Full Text:   <1462>

CLC number: TU991.2

On-line Access: 2010-11-08

Received: 2009-10-10

Revision Accepted: 2010-07-06

Crosschecked: 2010-10-12

Cited: 4

Clicked: 3468

Citations:  Bibtex RefMan EndNote GB/T7714

-   Go to

Article info.
1. Reference List
Open peer comments

Journal of Zhejiang University SCIENCE A 2010 Vol.11 No.11 P.868-878


Removal of sulfamethoxazole by nanofiltration membrane

Author(s):  Su-hua Wu, Hua-qiang Chu, Bing-zhi Dong, Jun-ru Zhou, Yu Huang

Affiliation(s):  School of Environmental Science and Engineering, Tongji University, Shanghai 200092, China, Shanghai Purge Filtration Technology Co., Ltd., Shanghai 200444, China

Corresponding email(s):   wusuhua@inbox.com, chq123zl@hotmail.com

Key Words:  Pharmaceutically active compounds (PhACs), Nanofiltration (NF) membrane, Electronic exclusion, Adsorption, Sulfamethoxazole (SMZ)

Su-hua Wu, Hua-qiang Chu, Bing-zhi Dong, Jun-ru Zhou, Yu Huang. Removal of sulfamethoxazole by nanofiltration membrane[J]. Journal of Zhejiang University Science A, 2010, 11(11): 868-878.

@article{title="Removal of sulfamethoxazole by nanofiltration membrane",
author="Su-hua Wu, Hua-qiang Chu, Bing-zhi Dong, Jun-ru Zhou, Yu Huang",
journal="Journal of Zhejiang University Science A",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Removal of sulfamethoxazole by nanofiltration membrane
%A Su-hua Wu
%A Hua-qiang Chu
%A Bing-zhi Dong
%A Jun-ru Zhou
%A Yu Huang
%J Journal of Zhejiang University SCIENCE A
%V 11
%N 11
%P 868-878
%@ 1673-565X
%D 2010
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.A0900606

T1 - Removal of sulfamethoxazole by nanofiltration membrane
A1 - Su-hua Wu
A1 - Hua-qiang Chu
A1 - Bing-zhi Dong
A1 - Jun-ru Zhou
A1 - Yu Huang
J0 - Journal of Zhejiang University Science A
VL - 11
IS - 11
SP - 868
EP - 878
%@ 1673-565X
Y1 - 2010
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.A0900606

The retention of sulfamethoxazole (SMZ) by nanofiltration (NF) membranes is strongly influenced by the pH value of the solution. The retention of SMZ reaches its peak value when the solution pH rises above its pKa2 value as the compound transforms into a negatively charged species. Charge repulsion is the main mechanism involved in SMZ removal by NF membranes. In this study, the removal of SMZ by NF membranes, as a function of solution chemistry, was examined at pH 8.9 to investigate the effect of solution conditions on charge repulsion. The results show that the retention of negatively charged SMZ is relatively independent of SMZ concentration, and an increase in the ionic strength of the solution causes a relatively small reduction in retention. A small effect of humic acid (HA) on SMZ retention was noticed at pH 8.9, which can be explained by a small but insignificant improvement in the zeta potential of the membrane caused by HA at high pH values. However, it was found that SMZ concentration in the feed decreased significantly in solutions containing tannic acid (TA). The Adams-Bohart model was applied to our experimental data and was found to be suitable for describing the initial part of the breakthrough curves. The adsorptive parameters of the membrane were determined.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


[1]Agbekodo, K.M., Legube, B., Dard, S., 1996. Atrazine and simazine removal mechanisms by nanofiltration: influence of natural organic matter concentration. Water Research, 30(11):2535-2542.

[2]Aksu, Z., Gönen, F., 2004. Biosorption of phenol by immobilized activated sludge in a continuous packed bed: prediction of breakthrough curves. Process Biochemistry, 39(5):599-613.

[3]Andreozzi, R., Raffaele, M., Nicklas, P., 2003. Phar-maceuticals in STP effluents and their solar photo-degradation in aquatic environment. Chemosphere, 50(10):1319-1330.

[4]Batt, A.L., Kim, S., Aga, D.S., 2007. Comparison of the occurrence of antibiotics in four full-scale wastewater treatment plants with varying designs and operation. Chemosphere, 68(3):428-435.

[5]Bellona, C., Drewes, J.E., Xu, P., Amy, G., 2004. Factors affecting the rejection of organic solutes during NF/RO treatment—a literature review. Water Research, 38(12):2795-2809.

[6]Childress, A.E., Elimelech, M., 1996. Effect of solution chemistry on the surface charge of polymeric reverse osmosis and nanofiltration membranes. Journal of Membrane Science, 119(2):253-268.

[7]Clara, M., Strenn, B., Gans, O., 2005. Removal of selected pharmaceuticals, fragrances and endocrine disrupting compounds in a membrane bioreactor and conventional wastewater treatment plants. Water Research, 39(19):4797-4807.

[8]Comerton, A.M., Andrews, R.C., Bagley, D.M., Yang, P., 2007. Membrane adsorption of endocrine disrupting compounds and pharmaceutically active compounds. Journal of Membrane Science, 303(1-2):267-277.

[9]Heberer, T., 2002. Tracking persistent pharmaceutical residues from municipal sewage to drinking water. Journal of Hydrology, 266(3-4):175-189.

[10]Hu, J.Y., Jin, X., Ong, S.L., 2007. Rejection of estrone by nanofiltration: Influence of solution chemistry. Journal of Membrane Science, 302(1-2):188-196.

[11]Kimura, K., Amy, G., Drewes, J., Watanabe, Y., 2003. Adsorption of hydrophobic compounds onto NF/RO membranes: an artifact leading to overestimation of rejection. Journal of Membrane Science, 221(1-2):89-101.

[12]Kimura, K., Toshima, S., Amy, G., Watanabe, Y., 2004. Rejection of neutral endocrine disrupting compounds (EDCs) and pharmaceutical active compounds (PhACs) by RO membranes. Journal of Membrane Science, 245(1-2):71-78.

[13]Kolpin, D.W., Furlong, E.T., Meyer, M.T., Thurman, E.M., Zuggg, S.D., Barber, L.B., Buxton, H.T., 2002. Pharmaceuticals, hormones, and other organic wastewater contaminants in US streams, 1999–2000: a national reconnaissance. Environmental Science & Technology, 36(6):1202-1211.

[14]Lee, S., Cho, J., Elimelech, M., 2005. Combined influence of natural organic matter (NOM) and colloidal particles on nanofiltration membrane fouling. Journal of Membrane Science, 262(1-2):27-41.

[15]Lindberg, R., Jarnheimer, P.A., Olsen, B., Johansson, M., Tysklind, M., 2004. Determination of antibiotic substances in hospital sewage water using solid phase extraction and liquid chromatography/mass spectrometry and group analogue internal standards. Chemosphere, 57(10):1479-1488.

[16]Nghiem, L.D., Schäfer, A.I., 2002. Adsorption and transport of trace contaminant estrone in NF/RO membrane. Environmental Engineering Science, 19(6):441-451.

[17]Nghiem, L.D., Hawkes, S., 2007. Effects of membrane fouling on the nanofiltration of pharmaceutically active compounds (PhACs): Mechanisms and role of membrane pore size. Separation and Purification Technology, 57(1):176-184.

[18]Nghiem, L.D., Schäfer, A.I., Waite, T.D., 2002. Adsorptive interactions between membranes and trace contaminants. Desalination, 147(1-3):269-274.

[19]Nghiem, L.D., Manis, A., Soldenhoff, K., 2004. Estrogenic hormone removal from wastewater using NF/RO membranes. Journal of Membrane Science, 242(1-2):37-45.

[20]Nghiem, L.D., Schäfer, A.I., Elimelech, M., 2005. Pharmaceutical retention mechanisms by nanofiltration membranes. Environmental Science & Technology, 39(19):7698-7705.

[21]Nghiem, L.D., Schäfer, A.I., Elimelech, M., 2006. Role of electrostatic interactions in the retention of pharmaceutically active contaminants by a loose nanofiltration membrane. Journal of Membrane Science, 286(1-2):52-59.

[22]Plakas, K.V., Karabelas, A.J., 2009. Triazine retention by nanofiltration in the presence of organic matter: The role of humic substance characteristics. Journal of Membrane Science, 336(1-2):86-100.

[23]Qiang, Z.M., Adams, C., 2004. Potentiometric determination of acid dissociation constants (pKa) for human and veterinary antibiotics. Water Research, 38(12):2874-2890.

[24]Schäfer, A.I., Nghiem, L.D., Waite, T.D., 2003. Removal of the natural hormone estrone from aqueous solutions using nanofiltration and reverse osmosis. Environmental Science & Technology, 37(1):182-188.

[25]Schäfer, A.I., Nghiem, L.D., Oschmann, N., 2006. Bisphenol A retention in the direct ultrafiltration of greywater. Journal of Membrane Science, 283(1-2):233-243.

[26]Sharma, V.K., Mishra, S.K., Ray, A.K., 2006. Kinetic assessment of the potassium ferrate (VI) oxidation of antibacterial drug sulfamethoxazole. Chemosphere, 62(1):128-134.

[27]Verliefde, A.R.D., Heijman, S.G.J., Cornelissen, E.R., Amy, G., van der Bruggen, B., van Dijk, J.C., 2007. Influence of electrostatic interactions on the rejection with NF and assessment of the removal efficiency during NF/GAC treatment of pharmaceutically active compounds in surface water. Water Research, 41(15):3227-3240.

[28]Yoon, Y., Westerhoff, P., Snyder, S.A., Wert, E.C., 2006. Nanofiltration and ultrafiltration of endocrine disrupting compounds, pharmaceuticals and personal care products. Journal of Membrane Science, 270(1-2):88-100.

[29]Zhang, Y., Causserand, C., Aimar, P., Cravedi, J.P., 2006. Removal of bisphenol A by a nanofiltration membrane in view of drinking water production. Water Research, 40(20):3793-3799.

Open peer comments: Debate/Discuss/Question/Opinion


Please provide your name, email address and a comment

Journal of Zhejiang University-SCIENCE, 38 Zheda Road, Hangzhou 310027, China
Tel: +86-571-87952783; E-mail: cjzhang@zju.edu.cn
Copyright © 2000 - Journal of Zhejiang University-SCIENCE