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Received: 2007-11-30

Revision Accepted: 2007-12-05

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Journal of Zhejiang University SCIENCE B 2008 Vol.9 No.1 P.16~21

http://doi.org/10.1631/jzus.B071605


A novel thioredoxin reductase inhibitor inhibits cell growth and induces apoptosis in HL-60 and K562 cells


Author(s):  Zuo-fu PENG, Lin-xiang LAN, Fang ZHAO, Jing LI, Qiang TAN, Han-wei YIN, Hui-hui ZENG

Affiliation(s):  Department of Chem-Biology, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China; more

Corresponding email(s):   zenghh@bjmu.edu.cn

Key Words:  Thioredoxin reductase (TrxR), Novel TrxR inhibitor, 1, 2-[bis(1, 2-benzisoselenazolone-3(2H)-ketone)]ethane (BBSKE), Apoptosis


Zuo-fu PENG, Lin-xiang LAN, Fang ZHAO, Jing LI, Qiang TAN, Han-wei YIN, Hui-hui ZENG. A novel thioredoxin reductase inhibitor inhibits cell growth and induces apoptosis in HL-60 and K562 cells[J]. Journal of Zhejiang University Science B, 2008, 9(1): 16~21.

@article{title="A novel thioredoxin reductase inhibitor inhibits cell growth and induces apoptosis in HL-60 and K562 cells",
author="Zuo-fu PENG, Lin-xiang LAN, Fang ZHAO, Jing LI, Qiang TAN, Han-wei YIN, Hui-hui ZENG",
journal="Journal of Zhejiang University Science B",
volume="9",
number="1",
pages="16~21",
year="2008",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B071605"
}

%0 Journal Article
%T A novel thioredoxin reductase inhibitor inhibits cell growth and induces apoptosis in HL-60 and K562 cells
%A Zuo-fu PENG
%A Lin-xiang LAN
%A Fang ZHAO
%A Jing LI
%A Qiang TAN
%A Han-wei YIN
%A Hui-hui ZENG
%J Journal of Zhejiang University SCIENCE B
%V 9
%N 1
%P 16~21
%@ 1673-1581
%D 2008
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B071605

TY - JOUR
T1 - A novel thioredoxin reductase inhibitor inhibits cell growth and induces apoptosis in HL-60 and K562 cells
A1 - Zuo-fu PENG
A1 - Lin-xiang LAN
A1 - Fang ZHAO
A1 - Jing LI
A1 - Qiang TAN
A1 - Han-wei YIN
A1 - Hui-hui ZENG
J0 - Journal of Zhejiang University Science B
VL - 9
IS - 1
SP - 16
EP - 21
%@ 1673-1581
Y1 - 2008
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B071605


Abstract: 
Human thioredoxin reductase (TrxR) system is associated with cancer cell growth and anti-apoptosis process. Effects of 1,2-[bis(1,2-benzisoselenazolone-3(2H)-ketone)]ethane (BBSKE), a novel TrxR inhibitor, were investigated on human leukemia cell lines HL-60 and K562. BBSKE treatment induced cell growth inhibition and apoptosis in both cell lines. apoptosis induced by BBSKE is through Bcl-2/Bax and caspase-3 pathways. Ehrlich’s ascites carcinoma-bearing mice were used to investigate the anti-tumor effect of BBSKE in vivo. Tumor-bearing mice treated with BBSKE showed an increase of life span with a comparable effect to cyclophosphamide (CTX). These results suggest a potential usage of BBSKE as a therapeutic agent against non-solid tumors.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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