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Journal of Zhejiang University SCIENCE B 2010 Vol.11 No.4 P.249-257

10.1631/jzus.B1000012


Relationships between serum lipid, lipoprotein, triglyceride-rich lipoprotein, and high-density lipoprotein particle concentrations in post-renal transplant patients


Author(s):  Elżbieta Kimak, Magdalena Hałabiś, Iwona Baranowicz-Gąszczyk

Affiliation(s):  Department of Laboratory Diagnostics, Medical University of Lublin, ul. Chodźki 1, 20-093 Lublin, Poland, Department of Nephrology, Medical University of Lublin, Jaczewskiego 8, 20-093 Lublin, Poland

Corresponding email(s):   elzbieta.kimak@wp.pl, magdalenahalabis@gmail.com

Key Words:  Lipid, Lipoprotein, High-density lipoprotein particle, Triglyceride-rich lipoprotein, Renal transplantation


Elżbieta Kimak, Magdalena Hałabiś, Iwona Baranowicz-Gąszczyk. Relationships between serum lipid, lipoprotein, triglyceride-rich lipoprotein, and high-density lipoprotein particle concentrations in post-renal transplant patients[J]. Journal of Zhejiang University Science B, 2010, 11(4): 249-257.

@article{title="Relationships between serum lipid, lipoprotein, triglyceride-rich lipoprotein, and high-density lipoprotein particle concentrations in post-renal transplant patients",
author="Elżbieta Kimak, Magdalena Hałabiś, Iwona Baranowicz-Gąszczyk",
journal="Journal of Zhejiang University Science B",
volume="11",
number="4",
pages="249-257",
year="2010",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1000012"
}

%0 Journal Article
%T Relationships between serum lipid, lipoprotein, triglyceride-rich lipoprotein, and high-density lipoprotein particle concentrations in post-renal transplant patients
%A Elżbieta Kimak
%A Magdalena Hałabiś
%A Iwona Baranowicz-Gąszczyk
%J Journal of Zhejiang University SCIENCE B
%V 11
%N 4
%P 249-257
%@ 1673-1581
%D 2010
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1000012

TY - JOUR
T1 - Relationships between serum lipid, lipoprotein, triglyceride-rich lipoprotein, and high-density lipoprotein particle concentrations in post-renal transplant patients
A1 - Elżbieta Kimak
A1 - Magdalena Hałabiś
A1 - Iwona Baranowicz-Gąszczyk
J0 - Journal of Zhejiang University Science B
VL - 11
IS - 4
SP - 249
EP - 257
%@ 1673-1581
Y1 - 2010
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1000012


Abstract: 
Objective: Disturbances in lipid and lipoprotein profiles in patients after kidney transplantation (Tx) are still not understood. Methods: Serum levels of lipids, lipoprotein, triglyceride-rich lipoproteins (TRLs), and high-density lipoprotein (HDL) particles were determined, lipid and lipoprotein ratios were calculated, and their relationships in Tx patients with hypertriglyceridemia (HTG) and lower apolipoprotein AI (apoAI) concentration were examined. Serum lipid and lipoprotein levels were measured in 109 Tx patients and 89 healthy subjects. HDL particle levels were determined by enzyme-linked immunosorbent assay (ELISA). Results: Tx patients had disturbed concentration, composition, and metabolism of TRLs and HDL particles. Multivariance analysis showed significant and positive correlation between HDL cholesterol/apoAI (HDL-C/apoAI) and HDL-C/HDL ratios, which indicates that both ratios could sensitively reflect changes in the HDL subclasses and their distribution into smaller size particles. In Tx patients, the decreased HDL-C/apoAI ratio indicates that, along with the decreased apoAI concentration, the HDL-C level is decreased. However, a low HDL-C/HDL ratio indicates that HDL particles in Tx patients transport lesser content of HDL-C but more triglyceride (TG) (high TG/HDL ratio), and thus are hypercatabolized and removed; therefore, concentration of HDL particles in serum was decreased. Conclusion: The decrease of HDL-C/apoAI ratio seems to be a good marker of HDL subclass distribution into smaller size particles.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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