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Journal of Zhejiang University SCIENCE B 2011 Vol.12 No.5 P.372-380

http://doi.org/10.1631/jzus.B1100015


Plasticity of human menstrual blood stem cells derived from the endometrium


Author(s):  Jian Lin, Dennis Xiang, Jin-long Zhang, Julie Allickson, Charlie Xiang

Affiliation(s):  State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China, Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA, Infectious Disease Unit, Zhejiang Armed Police Hospital, Jiaxing 314000, China, Cryo-Cell International Inc., Oldsmar, FL 34677, USA, S-Evans Biosciences, Hangzhou 311121, China, J. Craig Venter Institute, Rockville, MD 20850, USA

Corresponding email(s):   cxiang@zju.edu.cn

Key Words:  Menstrual blood-derived stem cells (MenSCs), Endometrium, Multipotent, Plasticity


Jian Lin, Dennis Xiang, Jin-long Zhang, Julie Allickson, Charlie Xiang. Plasticity of human menstrual blood stem cells derived from the endometrium[J]. Journal of Zhejiang University Science B, 2011, 12(5): 372-380.

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author="Jian Lin, Dennis Xiang, Jin-long Zhang, Julie Allickson, Charlie Xiang",
journal="Journal of Zhejiang University Science B",
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number="5",
pages="372-380",
year="2011",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1100015"
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%T Plasticity of human menstrual blood stem cells derived from the endometrium
%A Jian Lin
%A Dennis Xiang
%A Jin-long Zhang
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%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1100015

TY - JOUR
T1 - Plasticity of human menstrual blood stem cells derived from the endometrium
A1 - Jian Lin
A1 - Dennis Xiang
A1 - Jin-long Zhang
A1 - Julie Allickson
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J0 - Journal of Zhejiang University Science B
VL - 12
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PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B1100015


Abstract: 
Stem cells can be obtained from women’s menstrual blood derived from the endometrium. The cells display stem cell markers such as Oct-4, SSEA-4, Nanog, and c-kit (CD117), and have the potent ability to differentiate into various cell types, including the heart, nerve, bone, cartilage, and fat. There has been no evidence of teratoma, ectopic formation, or any immune response after transplantation into an animal model. These cells quickly regenerate after menstruation and secrete many growth factors to display recurrent angiogenesis. The plasticity and safety of the acquired cells have been demonstrated in many studies. menstrual blood-derived stem cells (MenSCs) provide an alternative source of adult stem cells for research and application in regenerative medicine. Here we summarize the multipotent properties and the plasticities of MenSCs and other endometrial stem cells from recent studies conducted both in vitro and in vivo.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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