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Received: 2011-09-06

Revision Accepted: 2011-11-04

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Journal of Zhejiang University SCIENCE B 2012 Vol.13 No.3 P.192-202


A meta-analysis of association between acne vulgaris and Demodex infestation

Author(s):  Ya-e Zhao, Li Hu, Li-ping Wu, Jun-xian Ma

Affiliation(s):  Department of Immunology and Pathogen Biology, Xi’an Jiaotong University College of Medicine, Xi’an 710061, China

Corresponding email(s):   zhaoyae@mail.xjtu.edu.cn

Key Words:  Demodex infestation, Acne vulgaris, Case-control study, Meta-analysis

Ya-e Zhao, Li Hu, Li-ping Wu, Jun-xian Ma. A meta-analysis of association between acne vulgaris and Demodex infestation[J]. Journal of Zhejiang University Science B, 2012, 13(3): 192-202.

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author="Ya-e Zhao, Li Hu, Li-ping Wu, Jun-xian Ma",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T A meta-analysis of association between acne vulgaris and Demodex infestation
%A Ya-e Zhao
%A Li Hu
%A Li-ping Wu
%A Jun-xian Ma
%J Journal of Zhejiang University SCIENCE B
%V 13
%N 3
%P 192-202
%@ 1673-1581
%D 2012
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1100285

T1 - A meta-analysis of association between acne vulgaris and Demodex infestation
A1 - Ya-e Zhao
A1 - Li Hu
A1 - Li-ping Wu
A1 - Jun-xian Ma
J0 - Journal of Zhejiang University Science B
VL - 13
IS - 3
SP - 192
EP - 202
%@ 1673-1581
Y1 - 2012
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1100285

Until now, etiology of acne vulgaris is still uncertain. Although clinicians usually deny the association between Demodex infestation and acne vulgaris, it has been proved in some clinical practices. To confirm the association between Demodex infestation and acne vulgaris, a meta-analysis was conducted. Predefined selection criteria were applied to search all published papers that analyzed the association between Demodex infestation and acne vulgaris (January 1950 to August 2011) in ISI Web of Knowledge, MEDLINE, and China National Knowledge Infrastructure (CNKI) databases. A meta-analysis was performed to calculate odds ratios (ORs) and 95% confidence intervals (CIs) based on fixed effects models or random effects models. We enrolled the 60 Chinese and 3 English papers in this meta-analysis, which covered Turkey and 25 different provinces/municipalities in China and 42130 participants including students and residents, aged from 1 to 78 years. The pooled OR in random effects models is 2.80 (95% CI, 2.34–3.36). Stability is robust according to sensitivity analysis. The fail-safe number is 18477, suggesting that at least 18477 articles with negative conclusions would be needed to reverse the conclusion that acne vulgaris was related to Demodex infestation. So the effect of publication bias was insignificant and could be ignored. It was concluded that acne vulgaris is associated with Demodex infestation. This indicates that when regular treatments for acne vulgaris are ineffective, examination of Demodex mites and necessary acaricidal therapies should be considered.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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