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CLC number: R776.1

On-line Access: 2013-01-08

Received: 2012-10-09

Revision Accepted: 2012-11-08

Crosschecked: 0000-00-00

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Citations:  Bibtex RefMan EndNote GB/T7714

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Journal of Zhejiang University SCIENCE B 2013 Vol.14 No.1 P.85-86


Curcumin and its emerging intraocular benefits

Author(s):  Shailendra Kapoor

Affiliation(s):  75 Crossing Place, Mechanicsville, VA 23223, USA

Corresponding email(s):   shailendrakapoor@yahoo.com

Key Words:  MCP-1, p-I?B?, microRNAs, NF-?B

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Shailendra Kapoor. Curcumin and its emerging intraocular benefits[J]. Journal of Zhejiang University Science B, 2013, 14(1): 85-86.

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I read with great interest the recent article Curcumin inhibits proliferation of human lens epithelial cells: a proteomic analysis by Hu et al. (2012), published in Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology). Curcumin may be of significant benefit in other optic disorders besides cataracts.

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[1]Alex, A.F., Spitznas, M., Tittel, A.P., Kurts, C., Eter, N., 2010. Inhibitory effect of epigallocatechin gallate (egcg), resveratrol, and curcumin on proliferation of human retinal pigment epithelial cells in vitro. Curr. Eye Res., 35(11):1021-1033.

[2]Gupta, S.K., Kumar, B., Nag, T.C., Agrawal, S.S., Agrawal, R., Agrawal, P., Saxena, R., Srivastava, S., 2011. Curcumin prevents experimental diabetic retinopathy in rats through its hypoglycemic, antioxidant, and anti-inflammatory mechanisms. J. Ocul. Pharmacol. Ther., 27(2):123-130.

[3]Hu, Y.H., Huang, X.R., Qi, M.X., Hou, B.Y., 2012. Curcumin inhibits proliferation of human lens epithelial cells: a proteomic analysis. J. Zhejiang Univ.-Sci. B (Biomed. & Biotechnol.), 13(5):402-407.

[4]Lu, H.F., Lai, K.C., Hsu, S.C., Lin, H.J., Yang, M.D., Chen, Y.L., Fan, M.J., Yang, J.S., Cheng, P.Y., Kuo, C.L., et al., 2009. Curcumin induces apoptosis through FAS and FADD, in caspase-3-dependent and -independent pathways in the N18 mouse-rat hybrid retina ganglion cells. Oncol. Rep., 22(1):97-104.

[5]Mandal, M.N., Patlolla, J.M., Zheng, L., Agbaga, M.P., Tran, J.T., Wicker, L., Kasus-Jacobi, A., Elliott, M.H., Rao, C.V., Anderson, R.E., 2009. Curcumin protects retinal cells from light- and oxidant stress-induced cell death. Free Radic. Biol. Med., 46(5):672-679.

[6]Sreenivasan, S., Thirumalai, K., Danda, R., Krishnakumar, S., 2012. Effect of curcumin on mirna expression in human y79 retinoblastoma cells. Curr. Eye Res., 37(5):421-428.

[7]Vasireddy, V., Chavali, V.R., Joseph, V.T., Kadam, R., Lin, J.H., Jamison, J.A., Kompella, U.B., Reddy, G.B., Ayyagari, R., 2011. Rescue of photoreceptor degeneration by curcumin in transgenic rats with p23h rhodopsin mutation. PLoS One, 6(6):e21193.

[8]Wang, L., Li, C., Guo, H., Kern, T.S., Huang, K., Zheng, L., 2011. Curcumin inhibits neuronal and vascular degeneration in retina after ischemia and reperfusion injury. PLoS One, 6(8):e23194.

[9]Woo, J.M., Shin, D.Y., Lee, S.J., Joe, Y., Zheng, M., Yim, J.H., Callaway, Z., Chung, H.T., 2012. Curcumin protects retinal pigment epithelial cells against oxidative stress via induction of heme oxygenase-1 expression and reduction of reactive oxygen. Mol. Vis., 18:901-908.

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