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Zhen-yu Yao


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Journal of Zhejiang University SCIENCE B 2018 Vol.19 No.3 P.183-198


Role of exosome-associated microRNA in diagnostic and therapeutic applications to metabolic disorders

Author(s):  Zhen-yu Yao, Wen-bin Chen, Shan-shan Shao, Shi-zhan Ma, Chong-bo Yang, Meng-zhu Li, Jia-jun Zhao, Ling Gao

Affiliation(s):  Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong University / Shandong Key Laboratory of Endocrinology and Lipid Metabolism / Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Jinan 250021, China; more

Corresponding email(s):   gaoling1@medmail.com.cn

Key Words:  Metabolic disorders, Exosome, Exosome-associated microRNA, Non-alcoholic fatty liver disease, Obesity, Diabetes mellitus

Zhen-yu Yao, Wen-bin Chen, Shan-shan Shao, Shi-zhan Ma, Chong-bo Yang, Meng-zhu Li, Jia-jun Zhao, Ling Gao. Role of exosome-associated microRNA in diagnostic and therapeutic applications to metabolic disorders[J]. Journal of Zhejiang University Science B, 2018, 19(3): 183-198.

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author="Zhen-yu Yao, Wen-bin Chen, Shan-shan Shao, Shi-zhan Ma, Chong-bo Yang, Meng-zhu Li, Jia-jun Zhao, Ling Gao",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Role of exosome-associated microRNA in diagnostic and therapeutic applications to metabolic disorders
%A Zhen-yu Yao
%A Wen-bin Chen
%A Shan-shan Shao
%A Shi-zhan Ma
%A Chong-bo Yang
%A Meng-zhu Li
%A Jia-jun Zhao
%A Ling Gao
%J Journal of Zhejiang University SCIENCE B
%V 19
%N 3
%P 183-198
%@ 1673-1581
%D 2018
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1600490

T1 - Role of exosome-associated microRNA in diagnostic and therapeutic applications to metabolic disorders
A1 - Zhen-yu Yao
A1 - Wen-bin Chen
A1 - Shan-shan Shao
A1 - Shi-zhan Ma
A1 - Chong-bo Yang
A1 - Meng-zhu Li
A1 - Jia-jun Zhao
A1 - Ling Gao
J0 - Journal of Zhejiang University Science B
VL - 19
IS - 3
SP - 183
EP - 198
%@ 1673-1581
Y1 - 2018
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1600490

metabolic disorders are classified clinically as a complex and varied group of diseases including metabolic syndrome, obesity, and diabetes mellitus. Fat toxicity, chronic inflammation, and oxidative stress, which may change cellular functions, are considered to play an essential role in the pathogenetic progress of metabolic disorders. Recent studies have found that cells secrete nanoscale vesicles containing proteins, lipids, nucleic acids, and membrane receptors, which mediate signal transduction and material transport to neighboring and distant cells. exosomes, one type of such vesicles, are reported to participate in multiple pathological processes including tumor metastasis, atherosclerosis, chronic inflammation, and insulin resistance. Research on exosomes has focused mainly on the proteins they contain, but recently the function of exosome-associated microRNA has drawn a lot of attention. exosome-associated microRNAs regulate the physiological function and pathological processes of metabolic disorders. They may also be useful as novel diagnostics and therapeutics given their special features of non-immunogenicity and quick extraction. In this paper, we summarize the structure, content, and functions of exosomes and the potential diagnostic and therapeutic applications of exosome-associated microRNAs in the treatment of metabolic disorders.



Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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