Full Text:   <910>

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CLC number: R34

On-line Access: 2018-03-05

Received: 2016-10-28

Revision Accepted: 2017-05-30

Crosschecked: 2018-02-10

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 ORCID:

Zhen-yu Yao

https://orcid.org/0000-0002-0616-8037

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Journal of Zhejiang University SCIENCE B 2018 Vol.19 No.3 P.183-198

10.1631/jzus.B1600490


Role of exosome-associated microRNA in diagnostic and therapeutic applications to metabolic disorders


Author(s):  Zhen-yu Yao, Wen-bin Chen, Shan-shan Shao, Shi-zhan Ma, Chong-bo Yang, Meng-zhu Li, Jia-jun Zhao, Ling Gao

Affiliation(s):  Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong University / Shandong Key Laboratory of Endocrinology and Lipid Metabolism / Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Jinan 250021, China; more

Corresponding email(s):   gaoling1@medmail.com.cn

Key Words:  Metabolic disorders, Exosome, Exosome-associated microRNA, Non-alcoholic fatty liver disease, Obesity, Diabetes mellitus


Zhen-yu Yao, Wen-bin Chen, Shan-shan Shao, Shi-zhan Ma, Chong-bo Yang, Meng-zhu Li, Jia-jun Zhao, Ling Gao. Role of exosome-associated microRNA in diagnostic and therapeutic applications to metabolic disorders[J]. Journal of Zhejiang University Science B, 2018, 19(3): 183-198.

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author="Zhen-yu Yao, Wen-bin Chen, Shan-shan Shao, Shi-zhan Ma, Chong-bo Yang, Meng-zhu Li, Jia-jun Zhao, Ling Gao",
journal="Journal of Zhejiang University Science B",
volume="19",
number="3",
pages="183-198",
year="2018",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1600490"
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%A Wen-bin Chen
%A Shan-shan Shao
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%A Meng-zhu Li
%A Jia-jun Zhao
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A1 - Zhen-yu Yao
A1 - Wen-bin Chen
A1 - Shan-shan Shao
A1 - Shi-zhan Ma
A1 - Chong-bo Yang
A1 - Meng-zhu Li
A1 - Jia-jun Zhao
A1 - Ling Gao
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SP - 183
EP - 198
%@ 1673-1581
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PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B1600490


Abstract: 
metabolic disorders are classified clinically as a complex and varied group of diseases including metabolic syndrome, obesity, and diabetes mellitus. Fat toxicity, chronic inflammation, and oxidative stress, which may change cellular functions, are considered to play an essential role in the pathogenetic progress of metabolic disorders. Recent studies have found that cells secrete nanoscale vesicles containing proteins, lipids, nucleic acids, and membrane receptors, which mediate signal transduction and material transport to neighboring and distant cells. exosomes, one type of such vesicles, are reported to participate in multiple pathological processes including tumor metastasis, atherosclerosis, chronic inflammation, and insulin resistance. Research on exosomes has focused mainly on the proteins they contain, but recently the function of exosome-associated microRNA has drawn a lot of attention. exosome-associated microRNAs regulate the physiological function and pathological processes of metabolic disorders. They may also be useful as novel diagnostics and therapeutics given their special features of non-immunogenicity and quick extraction. In this paper, we summarize the structure, content, and functions of exosomes and the potential diagnostic and therapeutic applications of exosome-associated microRNAs in the treatment of metabolic disorders.

外泌体相关的microRNA在代谢性疾病诊断和治疗中的作用

概要:代谢性疾病是指包括代谢综合征、肥胖和糖尿病在内的一系列复杂疾病.其中脂毒性、慢性炎症和氧化应激可以通过改变细胞功能,从而在代谢紊乱的病理进程中发挥重要作用.近期研究发现细胞可以分泌含有蛋白质、脂质、核酸的纳米级微小囊泡,介导相邻和远处细胞间的信号传导和物质转运.外泌体作为这类囊泡的一种,参与包括肿瘤转移、动脉粥样硬化、慢性炎症和胰岛素抵抗等多种病理过程.外泌体的研究大多集中于其所含的蛋白质,而近期关于外泌体相关microRNA的功能研究也日益受到关注.尤其是,现已证明外泌体相关microRNA参与了机体代谢的诸多生理、病理进程,为代谢性疾病的诊断和治疗提供了新的方向.本文总结了外泌体的结构、内容物及产生的机制(图1和图2);体液和细胞培养液中外泌体所含microRNA的种类、靶器官及其功能(表2);外泌体相关microRNA在代谢性疾病中的作用,以及在诊断和治疗方面的潜能.
关键词:代谢性疾病;外泌体;外泌体相关microRNA;非酒精性脂肪肝;肥胖;糖尿病

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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