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On-line Access: 2018-01-11

Received: 2017-02-02

Revision Accepted: 2017-03-14

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Journal of Zhejiang University SCIENCE B 2018 Vol.19 No.1 P.49-56


Electrocardiogram (ECG) patterns of left anterior fascicular block and conduction impairment in ventricular myocardium: a whole-heart model-based simulation study

Author(s):  Yuan Gao, Ling Xia, Ying-Lan Gong, Ding-Chang Zheng

Affiliation(s):  Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, China; more

Corresponding email(s):   xialing@zju.edu.cn, yinglangong@zju.edu.cn

Key Words:  Electrocardiogram (ECG), Simulation, Heart model, Left anterior fascicular block (LAFB)

Yuan Gao, Ling Xia, Ying-Lan Gong, Ding-Chang Zheng. Electrocardiogram (ECG) patterns of left anterior fascicular block and conduction impairment in ventricular myocardium: a whole-heart model-based simulation study[J]. Journal of Zhejiang University Science B, 2018, 19(1): 49-56.

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author="Yuan Gao, Ling Xia, Ying-Lan Gong, Ding-Chang Zheng",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Electrocardiogram (ECG) patterns of left anterior fascicular block and conduction impairment in ventricular myocardium: a whole-heart model-based simulation study
%A Yuan Gao
%A Ling Xia
%A Ying-Lan Gong
%A Ding-Chang Zheng
%J Journal of Zhejiang University SCIENCE B
%V 19
%N 1
%P 49-56
%@ 1673-1581
%D 2018
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1700029

T1 - Electrocardiogram (ECG) patterns of left anterior fascicular block and conduction impairment in ventricular myocardium: a whole-heart model-based simulation study
A1 - Yuan Gao
A1 - Ling Xia
A1 - Ying-Lan Gong
A1 - Ding-Chang Zheng
J0 - Journal of Zhejiang University Science B
VL - 19
IS - 1
SP - 49
EP - 56
%@ 1673-1581
Y1 - 2018
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1700029

left anterior fascicular block (LAFB) is a heart disease identifiable from an abnormal electrocardiogram (ECG). It has been reported that LAFB is associated with an increased risk of heart failure. Non-specific intraventricular conduction delay due to the lesions of the conduction bundles and slow cell to cell conduction has also been considered as another cause of heart failure. Since the location and mechanism of conduction delay have notable variability between individual patients, we hypothesized that the impaired conduction in the ventricular myocardium may lead to abnormal ECGs similar to LAFB ECG patterns. To test this hypothesis, based on a computer model with a three dimensional whole-heart anatomical structure, we simulated the cardiac exciting sequence map and 12-lead ECG caused by the block in the left anterior fascicle and by the slowed conduction velocity in the ventricular myocardium. The simulation results showed that the typical LAFB ECG patterns can also be observed from cases with slowed conduction velocity in the ventricular myocardium. The main differences were the duration of QRS and wave amplitude. In conclusion, our simulations provide a promising starting point to further investigate the underlying mechanism of heart failure with LAFB, which would provide a potential reference for LAFB diagnosis.




Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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